ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	202/1160	423/7206	2.40585450762e-56
ko05033	Nicotine addiction	50/1160	56/7206	1.06763349767e-33
ko04724	Glutamatergic synapse	88/1160	152/7206	1.59574008574e-32
ko05032	Morphine addiction	71/1160	110/7206	1.18511359864e-30
ko04727	GABAergic synapse	68/1160	110/7206	9.98083058069e-28
ko04713	Circadian entrainment	76/1160	136/7206	8.16954540811e-27
ko04728	Dopaminergic synapse	84/1160	185/7206	1.68435443146e-21
ko04725	Cholinergic synapse	75/1160	160/7206	2.55855762612e-20
ko04721	Synaptic vesicle cycle	49/1160	80/7206	4.87074107961e-20
ko04723	Retrograde endocannabinoid signaling	78/1160	175/7206	1.97226403415e-19
ko04024	cAMP signaling pathway	104/1160	279/7206	1.9899569224e-18
ko04911	Insulin secretion	56/1160	117/7206	5.73219862997e-16
ko04020	Calcium signaling pathway	95/1160	265/7206	1.1410235842e-15
ko04726	Serotonergic synapse	61/1160	137/7206	2.04471036004e-15
ko04744	Phototransduction	27/1160	36/7206	6.31195208257e-15
ko04742	Taste transduction	36/1160	61/7206	2.45946357459e-14
ko04921	Oxytocin signaling pathway	74/1160	209/7206	4.53503409912e-12
ko04261	Adrenergic signaling in cardiomyocytes	73/1160	205/7206	5.39039236634e-12
ko05031	Amphetamine addiction	41/1160	91/7206	5.57260146978e-11
ko03040	Spliceosome	1/1160	145/7206	3.1523868096e-10
ko04720	Long-term potentiation	42/1160	99/7206	3.37148410629e-10
ko05203	Viral carcinogenesis	13/1160	277/7206	3.13158350747e-09
ko04970	Salivary secretion	39/1160	95/7206	4.53158113686e-09
ko04740	Olfactory transduction	34/1160	80/7206	1.55912457626e-08
ko05030	Cocaine addiction	31/1160	73/7206	6.88301424047e-08
ko04925	Aldosterone synthesis and secretion	39/1160	105/7206	1.27216236746e-07
ko04360	Axon guidance	69/1160	233/7206	1.50885406739e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1160	74/7206	3.83095159349e-07
ko05322	Systemic lupus erythematosus	5/1160	151/7206	8.83340392444e-07
ko04971	Gastric acid secretion	35/1160	98/7206	2.14277475236e-06
ko04010	MAPK signaling pathway	84/1160	321/7206	2.53470425882e-06
ko03013	RNA transport	7/1160	166/7206	2.84467315027e-06
ko05168	Herpes simplex infection	9/1160	182/7206	4.98494727552e-06
ko04060	Cytokine-cytokine receptor interaction	10/1160	191/7206	5.28973864862e-06
ko05164	Influenza A	8/1160	167/7206	9.12991499311e-06
ko04745	Phototransduction - fly	17/1160	38/7206	2.8509407365e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1160	79/7206	3.43004191078e-05
ko04621	NOD-like receptor signaling pathway	8/1160	157/7206	3.70250337034e-05
ko04141	Protein processing in endoplasmic reticulum	11/1160	184/7206	3.98936677718e-05
ko04022	cGMP-PKG signaling pathway	58/1160	216/7206	4.44783500732e-05
ko04514	Cell adhesion molecules (CAMs)	39/1160	130/7206	5.61837563235e-05
ko04972	Pancreatic secretion	34/1160	111/7206	0.00011941478354
ko05414	Dilated cardiomyopathy	34/1160	112/7206	0.000134572428461
ko04070	Phosphatidylinositol signaling system	34/1160	112/7206	0.000134572428461
ko04730	Long-term depression	26/1160	78/7206	0.000144885717238
ko04072	Phospholipase D signaling pathway	52/1160	197/7206	0.000169166693592
ko04610	Complement and coagulation cascades	2/1160	79/7206	0.000174580466719
ko03008	Ribosome biogenesis in eukaryotes	2/1160	79/7206	0.000174580466719
ko05110	Vibrio cholerae infection	22/1160	63/7206	0.000209938282524
ko04540	Gap junction	37/1160	128/7206	0.000224249205078
ko04612	Antigen processing and presentation	2/1160	77/7206	0.000258175697323
ko04260	Cardiac muscle contraction	30/1160	98/7206	0.0002679174636
ko04966	Collecting duct acid secretion	12/1160	26/7206	0.000304196299061
ko05162	Measles	6/1160	120/7206	0.000365870101327
ko05169	Epstein-Barr virus infection	16/1160	206/7206	0.000492674004916
ko04110	Cell cycle	9/1160	145/7206	0.000529876901108
ko04924	Renin secretion	26/1160	86/7206	0.00095139153481
ko00240	Pyrimidine metabolism	6/1160	110/7206	0.000969490141448
ko04750	Inflammatory mediator regulation of TRP channels	34/1160	122/7206	0.00105810379115
ko04146	Peroxisome	4/1160	89/7206	0.00120591086633
ko05205	Proteoglycans in cancer	25/1160	271/7206	0.00128581904705
ko00520	Amino sugar and nucleotide sugar metabolism	1/1160	55/7206	0.00133017569278
ko04014	Ras signaling pathway	65/1160	279/7206	0.0015094869658
ko04976	Bile secretion	24/1160	80/7206	0.00182540291383
ko04064	NF-kappa B signaling pathway	5/1160	96/7206	0.00184445621555
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1160	59/7206	0.0019817538656
ko05140	Leishmaniasis	3/1160	75/7206	0.00225003241459
ko04120	Ubiquitin mediated proteolysis	10/1160	138/7206	0.00317214221595
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1160	14/7206	0.00331985275491
ko03420	Nucleotide excision repair	1/1160	46/7206	0.00448757579271
ko04923	Regulation of lipolysis in adipocytes	22/1160	77/7206	0.0047616388728
ko04658	Th1 and Th2 cell differentiation	6/1160	96/7206	0.00503149235433
ko04657	IL-17 signaling pathway	5/1160	87/7206	0.00503747520164
ko05133	Pertussis	5/1160	87/7206	0.00503747520164
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1160	182/7206	0.00553601274783
ko05321	Inflammatory bowel disease (IBD)	2/1160	56/7206	0.00575291295863
ko05161	Hepatitis B	15/1160	173/7206	0.00615622781873
ko03022	Basal transcription factors	1/1160	44/7206	0.00670262783833
ko05144	Malaria	1/1160	45/7206	0.00684031488898
ko00071	Fatty acid degradation	1/1160	45/7206	0.00684031488898
ko04915	Estrogen signaling pathway	33/1160	131/7206	0.00776085276122
ko05016	Huntington's disease	21/1160	215/7206	0.00826728780054
ko00480	Glutathione metabolism	2/1160	55/7206	0.00862479260374
ko05131	Shigellosis	5/1160	82/7206	0.00971760651906
ko00310	Lysine degradation	4/1160	73/7206	0.00973586847434
ko00590	Arachidonic acid metabolism	2/1160	52/7206	0.0123889318603
ko04371	Apelin signaling pathway	41/1160	177/7206	0.0126733062388
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1160	100/7206	0.0127154780589
ko04912	GnRH signaling pathway	30/1160	122/7206	0.0129087632037
ko00330	Arginine and proline metabolism	3/1160	61/7206	0.0133304564637
ko04622	RIG-I-like receptor signaling pathway	3/1160	62/7206	0.013648442443
ko00290	Valine, leucine and isoleucine biosynthesis	3/1160	4/7206	0.0146439545269
ko04218	Cellular senescence	17/1160	177/7206	0.0167678455409
ko05219	Bladder cancer	2/1160	48/7206	0.0177468943792
ko05215	Prostate cancer	9/1160	111/7206	0.0186611807562
ko00562	Inositol phosphate metabolism	23/1160	89/7206	0.0190013123055
ko03320	PPAR signaling pathway	4/1160	69/7206	0.0195859941909
ko04710	Circadian rhythm	13/1160	43/7206	0.0195958435106
ko05166	HTLV-I infection	33/1160	292/7206	0.022587565074
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1160	15/7206	0.0232366596267
ko04210	Apoptosis	18/1160	180/7206	0.0234543498333
ko00630	Glyoxylate and dicarboxylate metabolism	1/1160	38/7206	0.0235790213148
ko03410	Base excision repair	1/1160	38/7206	0.0235790213148
ko03018	RNA degradation	6/1160	84/7206	0.0239915125187
ko04115	p53 signaling pathway	5/1160	74/7206	0.0253008733946
ko04918	Thyroid hormone synthesis	22/1160	86/7206	0.0253438688011
ko04640	Hematopoietic cell lineage	4/1160	64/7206	0.0263747757888
ko04620	Toll-like receptor signaling pathway	8/1160	100/7206	0.0272801614051
ko04217	Necroptosis	18/1160	178/7206	0.0294750833584
ko04630	Jak-STAT signaling pathway	12/1160	132/7206	0.0304419748326
ko00860	Porphyrin and chlorophyll metabolism	1/1160	34/7206	0.0334170416803
ko04214	Apoptosis - fly	5/1160	72/7206	0.0347384127162
ko00280	Valine, leucine and isoleucine degradation	3/1160	54/7206	0.0384136033553
ko04510	Focal adhesion	27/1160	240/7206	0.0395159702723
ko04964	Proximal tubule bicarbonate reclamation	9/1160	29/7206	0.0396729565131
ko04140	Autophagy - animal	17/1160	164/7206	0.0413158849708
ko04711	Circadian rhythm - fly	5/1160	13/7206	0.0446992781815
ko04015	Rap1 signaling pathway	57/1160	278/7206	0.045643304721
ko05418	Fluid shear stress and atherosclerosis	18/1160	173/7206	0.0457816993432
ko05145	Toxoplasmosis	12/1160	126/7206	0.0492464097488