ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 31/255 191/7206 5.54161052406e-13 ko05164 Influenza A 29/255 167/7206 5.5943508009e-13 ko04380 Osteoclast differentiation 26/255 134/7206 6.58233875347e-13 ko04621 NOD-like receptor signaling pathway 28/255 157/7206 7.29048244877e-13 ko05340 Primary immunodeficiency 13/255 30/7206 7.05811737931e-12 ko05168 Herpes simplex infection 27/255 182/7206 1.64235600211e-10 ko04650 Natural killer cell mediated cytotoxicity 19/255 97/7206 8.0990979215e-10 ko05167 Kaposi's sarcoma-associated herpesvirus infection 26/255 191/7206 2.46908135406e-09 ko04217 Necroptosis 25/255 178/7206 2.63892232368e-09 ko05321 Inflammatory bowel disease (IBD) 14/255 56/7206 5.19996220226e-09 ko05162 Measles 20/255 120/7206 5.59465240417e-09 ko05145 Toxoplasmosis 20/255 126/7206 1.33471826215e-08 ko04630 Jak-STAT signaling pathway 20/255 132/7206 3.01821249958e-08 ko04658 Th1 and Th2 cell differentiation 17/255 96/7206 3.19626390343e-08 ko04064 NF-kappa B signaling pathway 17/255 96/7206 3.19626390343e-08 ko05152 Tuberculosis 24/255 187/7206 3.40131281942e-08 ko05140 Leishmaniasis 15/255 75/7206 3.85874405954e-08 ko04612 Antigen processing and presentation 15/255 77/7206 5.60321884335e-08 ko04659 Th17 cell differentiation 17/255 106/7206 1.45670077151e-07 ko04620 Toll-like receptor signaling pathway 16/255 100/7206 3.54209720724e-07 ko04660 T cell receptor signaling pathway 17/255 124/7206 1.45326525906e-06 ko05160 Hepatitis C 19/255 153/7206 1.61626384877e-06 ko05150 Staphylococcus aureus infection 9/255 36/7206 3.07746352823e-06 ko05133 Pertussis 13/255 87/7206 9.92343404887e-06 ko04662 B cell receptor signaling pathway 13/255 88/7206 1.12815029853e-05 ko04672 Intestinal immune network for IgA production 8/255 37/7206 3.48684728888e-05 ko05161 Hepatitis B 18/255 173/7206 3.64912711674e-05 ko05132 Salmonella infection 13/255 98/7206 3.68261221837e-05 ko04145 Phagosome 17/255 162/7206 5.40395473705e-05 ko04622 RIG-I-like receptor signaling pathway 10/255 62/7206 5.47031410114e-05 ko04664 Fc epsilon RI signaling pathway 11/255 77/7206 7.39540290802e-05 ko04062 Chemokine signaling pathway 19/255 201/7206 8.34816420398e-05 ko04610 Complement and coagulation cascades 11/255 79/7206 9.39554125858e-05 ko04666 Fc gamma R-mediated phagocytosis 14/255 122/7206 9.46814910856e-05 ko05330 Allograft rejection 6/255 24/7206 0.000145592387612 ko04611 Platelet activation 16/255 163/7206 0.000197550563852 ko05310 Asthma 5/255 17/7206 0.000232751493618 ko04640 Hematopoietic cell lineage 9/255 64/7206 0.000378490517884 ko05320 Autoimmune thyroid disease 6/255 29/7206 0.000442804808454 ko04623 Cytosolic DNA-sensing pathway 7/255 41/7206 0.000512932605957 ko05142 Chagas disease (American trypanosomiasis) 12/255 130/7206 0.00210007974731 ko05131 Shigellosis 9/255 82/7206 0.00231627443034 ko00140 Steroid hormone biosynthesis 6/255 41/7206 0.00293864363052 ko05416 Viral myocarditis 7/255 55/7206 0.00303942817171 ko05332 Graft-versus-host disease 4/255 18/7206 0.00316615953328 ko04668 TNF signaling pathway 11/255 120/7206 0.00336488225092 ko05034 Alcoholism 1/255 238/7206 0.00350161870438 ko05323 Rheumatoid arthritis 9/255 89/7206 0.00405535521342 ko05144 Malaria 6/255 45/7206 0.00473203620568 ko00120 Primary bile acid biosynthesis 4/255 20/7206 0.00474191444976 ko05169 Epstein-Barr virus infection 15/255 206/7206 0.00675423129233 ko04933 AGE-RAGE signaling pathway in diabetic complications 11/255 135/7206 0.0081572106561 ko04750 Inflammatory mediator regulation of TRP channels 10/255 122/7206 0.0109785786519 ko04670 Leukocyte transendothelial migration 12/255 151/7206 0.0111907718838 ko04390 Hippo signaling pathway 1/255 188/7206 0.0151241776696 ko05146 Amoebiasis 8/255 99/7206 0.0235924734222 ko04940 Type I diabetes mellitus 4/255 32/7206 0.025284729646 ko04514 Cell adhesion molecules (CAMs) 10/255 130/7206 0.0254703992672 ko04072 Phospholipase D signaling pathway 13/255 197/7206 0.0285978813795 ko04080 Neuroactive ligand-receptor interaction 7/255 423/7206 0.0289749958538 ko04917 Prolactin signaling pathway 7/255 87/7206 0.0338704166543 ko04210 Apoptosis 12/255 180/7206 0.0365799894209 ko03050 Proteasome 5/255 54/7206 0.0412602613219 ko05012 Parkinson's disease 1/255 155/7206 0.0453590918808 ko05134 Legionellosis 6/255 74/7206 0.0463261522242 ko02010 ABC transporters 4/255 39/7206 0.0478045513695 ko04510 Focal adhesion 3/255 240/7206 0.0492826227273 ko05166 HTLV-I infection 17/255 292/7206 0.0494530237406