ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	198/1163	423/7206	3.32516993205e-53
ko04724	Glutamatergic synapse	91/1163	152/7206	3.84318604961e-35
ko05033	Nicotine addiction	50/1163	56/7206	1.21468279771e-33
ko04727	GABAergic synapse	67/1163	110/7206	1.01960085117e-26
ko05032	Morphine addiction	67/1163	110/7206	1.01960085117e-26
ko04713	Circadian entrainment	75/1163	136/7206	6.69187364676e-26
ko04721	Synaptic vesicle cycle	52/1163	80/7206	6.90611866888e-23
ko04728	Dopaminergic synapse	85/1163	185/7206	4.30438029748e-22
ko04725	Cholinergic synapse	75/1163	160/7206	2.99800395464e-20
ko04723	Retrograde endocannabinoid signaling	77/1163	175/7206	1.0164781498e-18
ko04024	cAMP signaling pathway	104/1163	279/7206	2.31372041211e-18
ko04020	Calcium signaling pathway	98/1163	265/7206	4.2730805717e-17
ko04744	Phototransduction	28/1163	36/7206	4.04395903441e-16
ko04726	Serotonergic synapse	61/1163	137/7206	2.31635309355e-15
ko04911	Insulin secretion	55/1163	117/7206	3.17438321991e-15
ko04742	Taste transduction	36/1163	61/7206	2.67078351331e-14
ko04921	Oxytocin signaling pathway	77/1163	209/7206	1.93486164263e-13
ko04720	Long-term potentiation	46/1163	99/7206	1.03250278753e-12
ko05031	Amphetamine addiction	43/1163	91/7206	2.81019843415e-12
ko04261	Adrenergic signaling in cardiomyocytes	70/1163	205/7206	1.24846181793e-10
ko03040	Spliceosome	1/1163	145/7206	3.14614465151e-10
ko04740	Olfactory transduction	36/1163	80/7206	9.40685920156e-10
ko04970	Salivary secretion	38/1163	95/7206	1.80743259502e-08
ko05030	Cocaine addiction	31/1163	73/7206	7.31738248815e-08
ko04925	Aldosterone synthesis and secretion	39/1163	105/7206	1.35488553157e-07
ko04360	Axon guidance	69/1163	233/7206	1.58833309308e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1163	74/7206	4.05829608621e-07
ko05203	Viral carcinogenesis	17/1163	277/7206	4.39166814641e-07
ko04060	Cytokine-cytokine receptor interaction	9/1163	191/7206	1.20807738542e-06
ko04621	NOD-like receptor signaling pathway	6/1163	157/7206	1.60160916149e-06
ko04022	cGMP-PKG signaling pathway	62/1163	216/7206	2.08150176362e-06
ko04971	Gastric acid secretion	35/1163	98/7206	2.21414156539e-06
ko03013	RNA transport	7/1163	166/7206	2.88661330831e-06
ko05168	Herpes simplex infection	9/1163	182/7206	5.03309813836e-06
ko05322	Systemic lupus erythematosus	6/1163	151/7206	5.06019949204e-06
ko04514	Cell adhesion molecules (CAMs)	41/1163	130/7206	1.0144650207e-05
ko04141	Protein processing in endoplasmic reticulum	10/1163	184/7206	1.03659148275e-05
ko04966	Collecting duct acid secretion	14/1163	26/7206	1.06826121836e-05
ko04010	MAPK signaling pathway	81/1163	321/7206	1.754531529e-05
ko05164	Influenza A	9/1163	167/7206	2.70967258005e-05
ko04745	Phototransduction - fly	17/1163	38/7206	2.95132960579e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1163	79/7206	3.47944381849e-05
ko04072	Phospholipase D signaling pathway	53/1163	197/7206	0.000108052525166
ko04260	Cardiac muscle contraction	31/1163	98/7206	0.000134562426778
ko04070	Phosphatidylinositol signaling system	34/1163	112/7206	0.000139177668239
ko04110	Cell cycle	8/1163	145/7206	0.000139563075319
ko04730	Long-term depression	26/1163	78/7206	0.000149994814851
ko04610	Complement and coagulation cascades	2/1163	79/7206	0.000173497180315
ko03008	Ribosome biogenesis in eukaryotes	2/1163	79/7206	0.000173497180315
ko05110	Vibrio cholerae infection	22/1163	63/7206	0.00021710688449
ko04972	Pancreatic secretion	33/1163	111/7206	0.000352223797604
ko05140	Leishmaniasis	2/1163	75/7206	0.000386298366449
ko04064	NF-kappa B signaling pathway	4/1163	96/7206	0.000406044306993
ko04924	Renin secretion	27/1163	86/7206	0.00052821761678
ko04540	Gap junction	36/1163	128/7206	0.000580663231266
ko04014	Ras signaling pathway	67/1163	279/7206	0.000618221277401
ko05205	Proteoglycans in cancer	25/1163	271/7206	0.000992742478825
ko05162	Measles	7/1163	120/7206	0.000996815346298
ko05414	Dilated cardiomyopathy	32/1163	112/7206	0.00102127591558
ko05169	Epstein-Barr virus infection	17/1163	206/7206	0.00103228148803
ko04915	Estrogen signaling pathway	36/1163	131/7206	0.00104928365094
ko04750	Inflammatory mediator regulation of TRP channels	34/1163	122/7206	0.00107252701002
ko04146	Peroxisome	4/1163	89/7206	0.0012074156909
ko04612	Antigen processing and presentation	3/1163	77/7206	0.0015332012526
ko00590	Arachidonic acid metabolism	1/1163	52/7206	0.00198225574628
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1163	59/7206	0.00202276060525
ko04214	Apoptosis - fly	3/1163	72/7206	0.00321478201908
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1163	14/7206	0.00337074733881
ko00240	Pyrimidine metabolism	7/1163	110/7206	0.0036587090223
ko04626	Plant-pathogen interaction	8/1163	18/7206	0.00430406767339
ko03420	Nucleotide excision repair	1/1163	46/7206	0.00447020503764
ko04371	Apelin signaling pathway	43/1163	177/7206	0.00492776833138
ko04657	IL-17 signaling pathway	5/1163	87/7206	0.00502551518459
ko04976	Bile secretion	23/1163	80/7206	0.00519399730899
ko05321	Inflammatory bowel disease (IBD)	2/1163	56/7206	0.00573850213646
ko05161	Hepatitis B	15/1163	173/7206	0.0061902556548
ko04710	Circadian rhythm	14/1163	43/7206	0.00635872242775
ko03022	Basal transcription factors	1/1163	44/7206	0.00669336347949
ko04120	Ubiquitin mediated proteolysis	11/1163	138/7206	0.00683589099292
ko05144	Malaria	1/1163	45/7206	0.00685842942424
ko00071	Fatty acid degradation	1/1163	45/7206	0.00685842942424
ko00480	Glutathione metabolism	2/1163	55/7206	0.00865826630829
ko05131	Shigellosis	5/1163	82/7206	0.00971120288092
ko00310	Lysine degradation	4/1163	73/7206	0.00974133759772
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1163	182/7206	0.010390023881
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1163	100/7206	0.0128050088781
ko00330	Arginine and proline metabolism	3/1163	61/7206	0.0133390340997
ko04622	RIG-I-like receptor signaling pathway	3/1163	62/7206	0.0137043919085
ko05166	HTLV-I infection	32/1163	292/7206	0.0145382139554
ko04922	Glucagon signaling pathway	31/1163	128/7206	0.0152662864206
ko04912	GnRH signaling pathway	30/1163	122/7206	0.0174890074162
ko04973	Carbohydrate digestion and absorption	13/1163	42/7206	0.0178117780418
ko05133	Pertussis	6/1163	87/7206	0.0178610480289
ko04964	Proximal tubule bicarbonate reclamation	10/1163	29/7206	0.0182071558266
ko05145	Toxoplasmosis	11/1163	126/7206	0.019998792119
ko04350	TGF-beta signaling pathway	8/1163	103/7206	0.0207672499047
ko05418	Fluid shear stress and atherosclerosis	17/1163	173/7206	0.0210372724365
ko03018	RNA degradation	6/1163	84/7206	0.024041568065
ko04115	p53 signaling pathway	5/1163	74/7206	0.0252971846135
ko04930	Type II diabetes mellitus	15/1163	54/7206	0.0255564101329
ko04640	Hematopoietic cell lineage	4/1163	64/7206	0.0263166651302
ko04923	Regulation of lipolysis in adipocytes	20/1163	77/7206	0.0276269394984
ko05206	MicroRNAs in cancer	18/1163	177/7206	0.02931912121
ko05016	Huntington's disease	23/1163	215/7206	0.0298671395757
ko00860	Porphyrin and chlorophyll metabolism	1/1163	34/7206	0.0334171068208
ko00500	Starch and sucrose metabolism	1/1163	35/7206	0.0344487433297
ko04658	Th1 and Th2 cell differentiation	8/1163	96/7206	0.0355924553967
ko04330	Notch signaling pathway	4/1163	62/7206	0.0364416462599
ko04510	Focal adhesion	27/1163	240/7206	0.0396068785365
ko04210	Apoptosis	19/1163	180/7206	0.0398045342258
ko00562	Inositol phosphate metabolism	22/1163	89/7206	0.0406773463196
ko05202	Transcriptional misregulation in cancer	20/1163	188/7206	0.0437623867035
ko04711	Circadian rhythm - fly	5/1163	13/7206	0.0451418801792
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1163	92/7206	0.0460612615619
ko04015	Rap1 signaling pathway	57/1163	278/7206	0.0461569414179
ko05230	Central carbon metabolism in cancer	20/1163	81/7206	0.0466868176364
ko03320	PPAR signaling pathway	5/1163	69/7206	0.0469983131398
ko05034	Alcoholism	50/1163	238/7206	0.0480864267915
ko04217	Necroptosis	19/1163	178/7206	0.0492915382603