ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	196/1113	423/7206	4.81316614671e-55
ko04724	Glutamatergic synapse	86/1113	152/7206	3.66622874505e-32
ko05033	Nicotine addiction	48/1113	56/7206	1.94546495313e-31
ko04727	GABAergic synapse	65/1113	110/7206	5.23536035651e-26
ko05032	Morphine addiction	65/1113	110/7206	5.23536035651e-26
ko04713	Circadian entrainment	72/1113	136/7206	1.16785756755e-24
ko04721	Synaptic vesicle cycle	52/1113	80/7206	8.35365548508e-24
ko04728	Dopaminergic synapse	83/1113	185/7206	4.77610830153e-22
ko04725	Cholinergic synapse	73/1113	160/7206	4.97466555058e-20
ko04723	Retrograde endocannabinoid signaling	75/1113	175/7206	1.36150047385e-18
ko04742	Taste transduction	39/1113	61/7206	8.93488372973e-18
ko04024	cAMP signaling pathway	100/1113	279/7206	1.21189106411e-17
ko04020	Calcium signaling pathway	95/1113	265/7206	9.23735838655e-17
ko04911	Insulin secretion	53/1113	117/7206	1.06845542663e-14
ko04744	Phototransduction	26/1113	36/7206	3.32524020301e-14
ko04726	Serotonergic synapse	57/1113	137/7206	9.87659985702e-14
ko04921	Oxytocin signaling pathway	72/1113	209/7206	4.55565812037e-12
ko05031	Amphetamine addiction	41/1113	91/7206	1.44284857628e-11
ko04720	Long-term potentiation	43/1113	99/7206	2.04802308169e-11
ko04261	Adrenergic signaling in cardiomyocytes	70/1113	205/7206	2.07178737867e-11
ko03040	Spliceosome	1/1113	145/7206	8.50375474722e-10
ko04740	Olfactory transduction	35/1113	80/7206	1.21743513578e-09
ko04970	Salivary secretion	38/1113	95/7206	5.20623357667e-09
ko05203	Viral carcinogenesis	14/1113	277/7206	6.1014395872e-08
ko05030	Cocaine addiction	30/1113	73/7206	1.04972188955e-07
ko05168	Herpes simplex infection	6/1113	182/7206	1.93518573934e-07
ko04120	Ubiquitin mediated proteolysis	3/1113	138/7206	3.24864156572e-07
ko04925	Aldosterone synthesis and secretion	37/1113	105/7206	4.17742123009e-07
ko04360	Axon guidance	66/1113	233/7206	4.21819940203e-07
ko04022	cGMP-PKG signaling pathway	62/1113	216/7206	4.49934344987e-07
ko04060	Cytokine-cytokine receptor interaction	8/1113	191/7206	1.19754175499e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1113	74/7206	2.0518425619e-06
ko04971	Gastric acid secretion	34/1113	98/7206	2.99606010654e-06
ko04514	Cell adhesion molecules (CAMs)	41/1113	130/7206	3.40662361366e-06
ko03013	RNA transport	7/1113	166/7206	6.09076320035e-06
ko05164	Influenza A	7/1113	167/7206	6.188595451e-06
ko04966	Collecting duct acid secretion	14/1113	26/7206	6.29724808604e-06
ko04924	Renin secretion	30/1113	86/7206	6.77130589204e-06
ko04010	MAPK signaling pathway	79/1113	321/7206	1.19460695095e-05
ko04260	Cardiac muscle contraction	32/1113	98/7206	1.62706831727e-05
ko04621	NOD-like receptor signaling pathway	7/1113	157/7206	1.76860865455e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1113	79/7206	2.92494067077e-05
ko04141	Protein processing in endoplasmic reticulum	10/1113	184/7206	3.004180542e-05
ko05322	Systemic lupus erythematosus	7/1113	151/7206	5.16790816572e-05
ko04540	Gap junction	37/1113	128/7206	9.8282158658e-05
ko05414	Dilated cardiomyopathy	33/1113	112/7206	0.000166714465291
ko05162	Measles	5/1113	120/7206	0.000170543987192
ko05169	Epstein-Barr virus infection	14/1113	206/7206	0.000184490788095
ko04730	Long-term depression	25/1113	78/7206	0.000206393492644
ko04972	Pancreatic secretion	32/1113	111/7206	0.000284643817242
ko04745	Phototransduction - fly	15/1113	38/7206	0.000285030231027
ko05110	Vibrio cholerae infection	21/1113	63/7206	0.000337923018865
ko04750	Inflammatory mediator regulation of TRP channels	34/1113	122/7206	0.000355388887548
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1113	59/7206	0.000384645579285
ko05161	Hepatitis B	11/1113	173/7206	0.000384754472525
ko04612	Antigen processing and presentation	2/1113	77/7206	0.000402565999338
ko05205	Proteoglycans in cancer	22/1113	271/7206	0.000405259251517
ko04610	Complement and coagulation cascades	2/1113	79/7206	0.000417447164272
ko03008	Ribosome biogenesis in eukaryotes	2/1113	79/7206	0.000417447164272
ko05140	Leishmaniasis	2/1113	75/7206	0.000593708268293
ko04070	Phosphatidylinositol signaling system	31/1113	112/7206	0.000833792642798
ko04064	NF-kappa B signaling pathway	4/1113	96/7206	0.000889060666827
ko04014	Ras signaling pathway	64/1113	279/7206	0.000917095325993
ko04110	Cell cycle	9/1113	145/7206	0.00102325572839
ko04146	Peroxisome	4/1113	89/7206	0.00178223988267
ko04072	Phospholipase D signaling pathway	47/1113	197/7206	0.00180210818667
ko00480	Glutathione metabolism	1/1113	55/7206	0.00210905300778
ko04976	Bile secretion	23/1113	80/7206	0.00258826299445
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1113	14/7206	0.00259900357187
ko04640	Hematopoietic cell lineage	2/1113	64/7206	0.00277507052289
ko00590	Arachidonic acid metabolism	1/1113	52/7206	0.0031234948779
ko04915	Estrogen signaling pathway	33/1113	131/7206	0.00320864594383
ko04923	Regulation of lipolysis in adipocytes	22/1113	77/7206	0.00363965139981
ko00240	Pyrimidine metabolism	7/1113	110/7206	0.00504831856446
ko04371	Apelin signaling pathway	41/1113	177/7206	0.00596688236062
ko03420	Nucleotide excision repair	1/1113	46/7206	0.00691085506841
ko05321	Inflammatory bowel disease (IBD)	2/1113	56/7206	0.00863462928167
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1113	182/7206	0.00931514938423
ko01524	Platinum drug resistance	4/1113	76/7206	0.00999672229248
ko04630	Jak-STAT signaling pathway	10/1113	132/7206	0.0101450187092
ko05418	Fluid shear stress and atherosclerosis	15/1113	173/7206	0.0103767108753
ko03022	Basal transcription factors	1/1113	44/7206	0.0104547702127
ko05144	Malaria	1/1113	45/7206	0.0109234671494
ko00071	Fatty acid degradation	1/1113	45/7206	0.0109234671494
ko04140	Autophagy - animal	14/1113	164/7206	0.0115748210653
ko05215	Prostate cancer	8/1113	111/7206	0.0117690286093
ko05166	HTLV-I infection	30/1113	292/7206	0.012833615217
ko04626	Plant-pathogen interaction	7/1113	18/7206	0.0137151671871
ko05131	Shigellosis	5/1113	82/7206	0.0137739709722
ko03018	RNA degradation	5/1113	84/7206	0.0140161909265
ko04668	TNF signaling pathway	9/1113	120/7206	0.0147081993288
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1113	40/7206	0.0154069058192
ko00140	Steroid hormone biosynthesis	1/1113	41/7206	0.0154684595657
ko04620	Toll-like receptor signaling pathway	7/1113	100/7206	0.0170067772741
ko05145	Toxoplasmosis	10/1113	126/7206	0.0174615839173
ko00330	Arginine and proline metabolism	3/1113	61/7206	0.0194138379485
ko04622	RIG-I-like receptor signaling pathway	3/1113	62/7206	0.0199048423737
ko04214	Apoptosis - fly	4/1113	72/7206	0.020099612142
ko04210	Apoptosis	17/1113	180/7206	0.021487783255
ko04658	Th1 and Th2 cell differentiation	7/1113	96/7206	0.0226108469271
ko00630	Glyoxylate and dicarboxylate metabolism	1/1113	38/7206	0.0229190047078
ko04657	IL-17 signaling pathway	6/1113	87/7206	0.0243664699933
ko05133	Pertussis	6/1113	87/7206	0.0243664699933
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1113	100/7206	0.0246409970898
ko04916	Melanogenesis	32/1113	142/7206	0.0250490625371
ko00260	Glycine, serine and threonine metabolism	2/1113	48/7206	0.0262284360107
ko05219	Bladder cancer	2/1113	48/7206	0.0262284360107
ko05206	MicroRNAs in cancer	17/1113	177/7206	0.0269734606291
ko04350	TGF-beta signaling pathway	8/1113	103/7206	0.0275583256506
ko03320	PPAR signaling pathway	4/1113	69/7206	0.0276490446779
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1113	92/7206	0.0290775372083
ko04933	AGE-RAGE signaling pathway in diabetic complications	12/1113	135/7206	0.0304675669715
ko04912	GnRH signaling pathway	28/1113	122/7206	0.0305600509551
ko05212	Pancreatic cancer	6/1113	83/7206	0.032775241959
ko04964	Proximal tubule bicarbonate reclamation	9/1113	29/7206	0.0339715747621
ko04115	p53 signaling pathway	5/1113	74/7206	0.0351278439489
ko00982	Drug metabolism - cytochrome P450	1/1113	37/7206	0.035904821945
ko04930	Type II diabetes mellitus	14/1113	54/7206	0.0381574651633
ko00620	Pyruvate metabolism	2/1113	46/7206	0.038171044101
ko00270	Cysteine and methionine metabolism	2/1113	47/7206	0.0394625419514
ko04270	Vascular smooth muscle contraction	33/1113	154/7206	0.0423675979921
ko05034	Alcoholism	48/1113	238/7206	0.0446439386904
ko04217	Necroptosis	18/1113	178/7206	0.0458926696304
ko00310	Lysine degradation	5/1113	73/7206	0.0486246578999