ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	200/1189	423/7206	5.52996487659e-53
ko04724	Glutamatergic synapse	92/1189	152/7206	2.92453211556e-35
ko05033	Nicotine addiction	49/1189	56/7206	1.38576342828e-31
ko05032	Morphine addiction	70/1189	110/7206	5.7215363174e-29
ko04713	Circadian entrainment	78/1189	136/7206	8.69234267597e-28
ko04727	GABAergic synapse	68/1189	110/7206	4.61012937753e-27
ko04728	Dopaminergic synapse	88/1189	185/7206	1.84848626715e-23
ko04725	Cholinergic synapse	80/1189	160/7206	3.53396643291e-23
ko04721	Synaptic vesicle cycle	51/1189	80/7206	1.88791559249e-21
ko04723	Retrograde endocannabinoid signaling	79/1189	175/7206	2.08597467915e-19
ko04024	cAMP signaling pathway	106/1189	279/7206	1.07594402286e-18
ko04020	Calcium signaling pathway	102/1189	265/7206	2.61124252416e-18
ko04726	Serotonergic synapse	65/1189	137/7206	1.58576142043e-17
ko04742	Taste transduction	39/1189	61/7206	9.38726031715e-17
ko04921	Oxytocin signaling pathway	82/1189	209/7206	1.22495269614e-15
ko04911	Insulin secretion	56/1189	117/7206	1.77275693282e-15
ko04744	Phototransduction	27/1189	36/7206	1.18848207977e-14
ko04720	Long-term potentiation	49/1189	99/7206	2.01676768152e-14
ko05031	Amphetamine addiction	45/1189	91/7206	2.48398944925e-13
ko04261	Adrenergic signaling in cardiomyocytes	76/1189	205/7206	5.02591461053e-13
ko04970	Salivary secretion	45/1189	95/7206	1.73827031975e-12
ko03040	Spliceosome	1/1189	145/7206	1.94539984354e-10
ko04925	Aldosterone synthesis and secretion	42/1189	105/7206	6.34254207924e-09
ko04971	Gastric acid secretion	40/1189	98/7206	7.32289629896e-09
ko04740	Olfactory transduction	35/1189	80/7206	7.39001578463e-09
ko04060	Cytokine-cytokine receptor interaction	7/1189	191/7206	3.05050039939e-08
ko05030	Cocaine addiction	32/1189	73/7206	3.07966995863e-08
ko05203	Viral carcinogenesis	16/1189	277/7206	5.75166281239e-08
ko04360	Axon guidance	71/1189	233/7206	7.34864868783e-08
ko05168	Herpes simplex infection	7/1189	182/7206	1.39462153301e-07
ko04070	Phosphatidylinositol signaling system	41/1189	112/7206	2.15339128058e-07
ko04022	cGMP-PKG signaling pathway	65/1189	216/7206	5.30015928598e-07
ko05322	Systemic lupus erythematosus	5/1189	151/7206	5.96048870754e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1189	74/7206	6.62972042549e-07
ko04010	MAPK signaling pathway	87/1189	321/7206	9.81418934999e-07
ko03013	RNA transport	7/1189	166/7206	1.27099545658e-06
ko04540	Gap junction	43/1189	128/7206	1.64577661728e-06
ko04730	Long-term depression	30/1189	78/7206	3.18964616284e-06
ko04745	Phototransduction - fly	18/1189	38/7206	8.79776923693e-06
ko04972	Pancreatic secretion	37/1189	111/7206	1.28428540602e-05
ko04966	Collecting duct acid secretion	14/1189	26/7206	1.39112815744e-05
ko04120	Ubiquitin mediated proteolysis	6/1189	138/7206	1.39712273769e-05
ko04621	NOD-like receptor signaling pathway	8/1189	157/7206	1.74290018685e-05
ko05164	Influenza A	9/1189	167/7206	1.87765340766e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1189	122/7206	2.02944150078e-05
ko04924	Renin secretion	30/1189	86/7206	2.69919329494e-05
ko05110	Vibrio cholerae infection	24/1189	63/7206	4.09539442148e-05
ko04014	Ras signaling pathway	72/1189	279/7206	5.0525960291e-05
ko04072	Phospholipase D signaling pathway	55/1189	197/7206	5.40278801561e-05
ko04141	Protein processing in endoplasmic reticulum	12/1189	184/7206	7.29713103324e-05
ko04110	Cell cycle	8/1189	145/7206	9.77340722514e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1189	79/7206	0.000100691056476
ko04514	Cell adhesion molecules (CAMs)	39/1189	130/7206	0.000107754060438
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1189	59/7206	0.000115753920572
ko04610	Complement and coagulation cascades	2/1189	79/7206	0.000174375577003
ko03008	Ribosome biogenesis in eukaryotes	2/1189	79/7206	0.000174375577003
ko04976	Bile secretion	27/1189	80/7206	0.000187155057972
ko05414	Dilated cardiomyopathy	34/1189	112/7206	0.000256661576875
ko04612	Antigen processing and presentation	2/1189	77/7206	0.000267465917524
ko05169	Epstein-Barr virus infection	16/1189	206/7206	0.0002717727185
ko04915	Estrogen signaling pathway	38/1189	131/7206	0.000304270056045
ko04260	Cardiac muscle contraction	30/1189	98/7206	0.000490121868921
ko04371	Apelin signaling pathway	47/1189	177/7206	0.000638363096404
ko04146	Peroxisome	4/1189	89/7206	0.000817779403617
ko00480	Glutathione metabolism	1/1189	55/7206	0.000850276290102
ko04626	Plant-pathogen interaction	9/1189	18/7206	0.001032406297
ko04064	NF-kappa B signaling pathway	5/1189	96/7206	0.00127235268273
ko04912	GnRH signaling pathway	34/1189	122/7206	0.00128407259738
ko05140	Leishmaniasis	3/1189	75/7206	0.00148928656031
ko05162	Measles	8/1189	120/7206	0.00182223274383
ko00590	Arachidonic acid metabolism	1/1189	52/7206	0.00203487688366
ko00562	Inositol phosphate metabolism	26/1189	89/7206	0.00231315321129
ko05205	Proteoglycans in cancer	27/1189	271/7206	0.00255522155002
ko00240	Pyrimidine metabolism	7/1189	110/7206	0.00259862935733
ko00330	Arginine and proline metabolism	2/1189	61/7206	0.00266743961526
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1189	14/7206	0.00383822780112
ko04015	Rap1 signaling pathway	64/1189	278/7206	0.00385872358909
ko05144	Malaria	1/1189	45/7206	0.00439151805457
ko00071	Fatty acid degradation	1/1189	45/7206	0.00439151805457
ko03420	Nucleotide excision repair	1/1189	46/7206	0.00441086755243
ko04964	Proximal tubule bicarbonate reclamation	11/1189	29/7206	0.00455355678425
ko04657	IL-17 signaling pathway	5/1189	87/7206	0.00512263310486
ko05321	Inflammatory bowel disease (IBD)	2/1189	56/7206	0.00575333947134
ko04916	Melanogenesis	36/1189	142/7206	0.00596985020313
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1189	182/7206	0.00625120144095
ko03022	Basal transcription factors	1/1189	44/7206	0.00673623446605
ko00310	Lysine degradation	4/1189	73/7206	0.00679182209432
ko03018	RNA degradation	5/1189	84/7206	0.00703905953163
ko05166	HTLV-I infection	32/1189	292/7206	0.00781522355074
ko04270	Vascular smooth muscle contraction	38/1189	154/7206	0.00817944733037
ko04330	Notch signaling pathway	3/1189	62/7206	0.00918752914769
ko04622	RIG-I-like receptor signaling pathway	3/1189	62/7206	0.00918752914769
ko05214	Glioma	22/1189	79/7206	0.00930931223657
ko04214	Apoptosis - fly	4/1189	72/7206	0.00971060164327
ko04217	Necroptosis	17/1189	178/7206	0.0102450912066
ko04922	Glucagon signaling pathway	32/1189	128/7206	0.0115700612697
ko04658	Th1 and Th2 cell differentiation	7/1189	96/7206	0.012099384995
ko05231	Choline metabolism in cancer	33/1189	134/7206	0.0134829114863
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1189	100/7206	0.0140715565613
ko00630	Glyoxylate and dicarboxylate metabolism	1/1189	38/7206	0.0147813196452
ko03410	Base excision repair	1/1189	38/7206	0.0147813196452
ko05145	Toxoplasmosis	11/1189	126/7206	0.0151639904838
ko04350	TGF-beta signaling pathway	8/1189	103/7206	0.015275796974
ko04062	Chemokine signaling pathway	46/1189	201/7206	0.0159338719585
ko05161	Hepatitis B	17/1189	173/7206	0.0165911987692
ko04722	Neurotrophin signaling pathway	38/1189	160/7206	0.0172690567854
ko00260	Glycine, serine and threonine metabolism	2/1189	48/7206	0.0176290785161
ko04115	p53 signaling pathway	5/1189	74/7206	0.0182418280821
ko01524	Platinum drug resistance	5/1189	76/7206	0.0185205932294
ko04923	Regulation of lipolysis in adipocytes	21/1189	77/7206	0.0191266867067
ko04973	Carbohydrate digestion and absorption	13/1189	42/7206	0.0194170201949
ko05131	Shigellosis	6/1189	82/7206	0.0236906957928
ko04668	TNF signaling pathway	11/1189	120/7206	0.0256617959113
ko04640	Hematopoietic cell lineage	4/1189	64/7206	0.0263193106826
ko05034	Alcoholism	52/1189	238/7206	0.0264590561171
ko04114	Oocyte meiosis	33/1189	139/7206	0.027535455233
ko04918	Thyroid hormone synthesis	22/1189	86/7206	0.0279400468241
ko05418	Fluid shear stress and atherosclerosis	18/1189	173/7206	0.028994087263
ko05133	Pertussis	7/1189	87/7206	0.0291995861105
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1189	92/7206	0.0333650533128
ko00860	Porphyrin and chlorophyll metabolism	1/1189	34/7206	0.0337315340913
ko03320	PPAR signaling pathway	5/1189	69/7206	0.0340706537712
ko04960	Aldosterone-regulated sodium reabsorption	12/1189	41/7206	0.0344976246171
ko04620	Toll-like receptor signaling pathway	9/1189	100/7206	0.0414619737475
ko04630	Jak-STAT signaling pathway	13/1189	132/7206	0.0431858414931
ko00512	Mucin type O-glycan biosynthesis	9/1189	29/7206	0.0440047126018
ko04659	Th17 cell differentiation	10/1189	106/7206	0.0478930794553
ko05340	Primary immunodeficiency	1/1189	30/7206	0.0489735727819