ko pathway ratio_in_study ratio_in_pop p_value ko04710 Circadian rhythm 12/351 43/7206 5.77137520191e-07 ko04713 Circadian entrainment 21/351 136/7206 2.16084677011e-06 ko05032 Morphine addiction 18/351 110/7206 5.03099518094e-06 ko04020 Calcium signaling pathway 31/351 265/7206 5.68592911617e-06 ko04921 Oxytocin signaling pathway 26/351 209/7206 8.68212533932e-06 ko04725 Cholinergic synapse 22/351 160/7206 8.76040509364e-06 ko04724 Glutamatergic synapse 21/351 152/7206 1.30413986666e-05 ko04727 GABAergic synapse 17/351 110/7206 2.01342085274e-05 ko04723 Retrograde endocannabinoid signaling 22/351 175/7206 3.67432165579e-05 ko04911 Insulin secretion 17/351 117/7206 4.56374528921e-05 ko05033 Nicotine addiction 11/351 56/7206 6.45768386209e-05 ko04925 Aldosterone synthesis and secretion 15/351 105/7206 0.000154898899507 ko04728 Dopaminergic synapse 21/351 185/7206 0.000326690966939 ko04726 Serotonergic synapse 17/351 137/7206 0.000329653883117 ko04970 Salivary secretion 13/351 95/7206 0.000645142756773 ko04720 Long-term potentiation 13/351 99/7206 0.000959257868229 ko04070 Phosphatidylinositol signaling system 14/351 112/7206 0.00101511857144 ko05031 Amphetamine addiction 12/351 91/7206 0.00143755473313 ko04745 Phototransduction - fly 7/351 38/7206 0.00208922393728 ko02010 ABC transporters 7/351 39/7206 0.00244196011608 ko04024 cAMP signaling pathway 25/351 279/7206 0.00267968014924 ko04971 Gastric acid secretion 12/351 98/7206 0.00272714899337 ko04360 Axon guidance 22/351 233/7206 0.00276351125155 ko04068 FoxO signaling pathway 17/351 167/7206 0.00327066759422 ko04721 Synaptic vesicle cycle 10/351 80/7206 0.00519273101599 ko04922 Glucagon signaling pathway 14/351 128/7206 0.00521501872703 ko00680 Methane metabolism 6/351 34/7206 0.00540180768308 ko04022 cGMP-PKG signaling pathway 20/351 216/7206 0.00550470793125 ko04514 Cell adhesion molecules (CAMs) 14/351 130/7206 0.00561284483457 ko04744 Phototransduction 6/351 36/7206 0.00720939738088 ko04152 AMPK signaling pathway 16/351 161/7206 0.0078400692255 ko00010 Glycolysis / Gluconeogenesis 9/351 74/7206 0.00936782619736 ko04626 Plant-pathogen interaction 4/351 18/7206 0.00983227108539 ko05203 Viral carcinogenesis 5/351 277/7206 0.010191770485 ko04972 Pancreatic secretion 12/351 111/7206 0.0112710068087 ko04964 Proximal tubule bicarbonate reclamation 5/351 29/7206 0.0120428052053 ko04261 Adrenergic signaling in cardiomyocytes 18/351 205/7206 0.0130203141204 ko00290 Valine, leucine and isoleucine biosynthesis 2/351 4/7206 0.013296625549 ko04960 Aldosterone-regulated sodium reabsorption 6/351 41/7206 0.0135776647313 ko04930 Type II diabetes mellitus 7/351 54/7206 0.0150791255729 ko04740 Olfactory transduction 9/351 80/7206 0.0152463333788 ko05224 Breast cancer 2/351 174/7206 0.0182938674454 ko04072 Phospholipase D signaling pathway 17/351 197/7206 0.0183845119423 ko03010 Ribosome 1/351 129/7206 0.0214430101815 ko04711 Circadian rhythm - fly 3/351 13/7206 0.0227604093953 ko04060 Cytokine-cytokine receptor interaction 3/351 191/7206 0.0258940605326 ko05162 Measles 1/351 120/7206 0.0308350302542 ko00340 Histidine metabolism 4/351 25/7206 0.0311177786525 ko04371 Apelin signaling pathway 15/351 177/7206 0.0323621572603 ko04213 Longevity regulating pathway - multiple species 9/351 86/7206 0.0367662767695 ko04920 Adipocytokine signaling pathway 9/351 89/7206 0.0400241035873 ko04012 ErbB signaling pathway 10/351 109/7206 0.0432548791678 ko00240 Pyrimidine metabolism 1/351 110/7206 0.0442810778136 ko00360 Phenylalanine metabolism 3/351 17/7206 0.0468915006126 ko00901 Indole alkaloid biosynthesis 1/351 1/7206 0.048709408826 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/351 1/7206 0.048709408826 ko04110 Cell cycle 2/351 145/7206 0.0487530341418