ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	209/1291	423/7206	4.30900112291e-53
ko04724	Glutamatergic synapse	91/1291	152/7206	2.03775782053e-31
ko05033	Nicotine addiction	49/1291	56/7206	7.53849712732e-30
ko04713	Circadian entrainment	79/1291	136/7206	3.73338694645e-26
ko05032	Morphine addiction	68/1291	110/7206	7.17383938348e-25
ko04727	GABAergic synapse	67/1291	110/7206	5.47473689772e-24
ko04728	Dopaminergic synapse	87/1291	185/7206	2.8494738627e-20
ko04721	Synaptic vesicle cycle	51/1291	80/7206	8.44254767343e-20
ko04911	Insulin secretion	62/1291	117/7206	5.30085745844e-18
ko04725	Cholinergic synapse	75/1291	160/7206	1.60277418475e-17
ko04024	cAMP signaling pathway	109/1291	279/7206	1.96391007983e-17
ko04020	Calcium signaling pathway	104/1291	265/7206	1.10197275598e-16
ko04723	Retrograde endocannabinoid signaling	78/1291	175/7206	1.33864616928e-16
ko04742	Taste transduction	40/1291	61/7206	1.96717925368e-16
ko04744	Phototransduction	28/1291	36/7206	6.59926663468e-15
ko04740	Olfactory transduction	45/1291	80/7206	1.10472095184e-14
ko04726	Serotonergic synapse	62/1291	137/7206	8.22770642019e-14
ko04921	Oxytocin signaling pathway	81/1291	209/7206	6.00457436556e-13
ko04970	Salivary secretion	47/1291	95/7206	1.64165729214e-12
ko05031	Amphetamine addiction	45/1291	91/7206	5.02389050919e-12
ko04261	Adrenergic signaling in cardiomyocytes	78/1291	205/7206	6.50543362873e-12
ko03040	Spliceosome	1/1291	145/7206	1.55714350774e-11
ko04720	Long-term potentiation	46/1291	99/7206	4.57187332335e-11
ko04971	Gastric acid secretion	43/1291	98/7206	1.84611654467e-09
ko04925	Aldosterone synthesis and secretion	44/1291	105/7206	7.68463785599e-09
ko05203	Viral carcinogenesis	18/1291	277/7206	3.58110163859e-08
ko04022	cGMP-PKG signaling pathway	72/1291	216/7206	3.64482854227e-08
ko05030	Cocaine addiction	33/1291	73/7206	5.92920764642e-08
ko04976	Bile secretion	35/1291	80/7206	6.55082611033e-08
ko05164	Influenza A	7/1291	167/7206	1.1152743113e-07
ko03013	RNA transport	7/1291	166/7206	1.67700593079e-07
ko04360	Axon guidance	74/1291	233/7206	2.00281308115e-07
ko05168	Herpes simplex infection	9/1291	182/7206	2.27050469766e-07
ko04060	Cytokine-cytokine receptor interaction	10/1291	191/7206	2.56507637241e-07
ko04120	Ubiquitin mediated proteolysis	5/1291	138/7206	4.68271203021e-07
ko04924	Renin secretion	35/1291	86/7206	5.98313043391e-07
ko04141	Protein processing in endoplasmic reticulum	10/1291	184/7206	7.49490299984e-07
ko04621	NOD-like receptor signaling pathway	7/1291	157/7206	7.7028055696e-07
ko04972	Pancreatic secretion	40/1291	111/7206	4.36095840299e-06
ko04964	Proximal tubule bicarbonate reclamation	16/1291	29/7206	6.6579918484e-06
ko05169	Epstein-Barr virus infection	15/1291	206/7206	1.23558778107e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1291	74/7206	1.97479253659e-05
ko05322	Systemic lupus erythematosus	9/1291	151/7206	2.27645900508e-05
ko04514	Cell adhesion molecules (CAMs)	43/1291	130/7206	2.4659757553e-05
ko04260	Cardiac muscle contraction	35/1291	98/7206	2.49441293115e-05
ko04745	Phototransduction - fly	18/1291	38/7206	2.84984294157e-05
ko05162	Measles	6/1291	120/7206	3.60855369483e-05
ko04966	Collecting duct acid secretion	14/1291	26/7206	3.67565847585e-05
ko04540	Gap junction	42/1291	128/7206	3.7224074173e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1291	79/7206	4.4410414553e-05
ko04110	Cell cycle	9/1291	145/7206	6.46611207046e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1291	79/7206	7.88732736122e-05
ko04064	NF-kappa B signaling pathway	4/1291	96/7206	7.95890508705e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1291	59/7206	0.000115916467963
ko05205	Proteoglycans in cancer	26/1291	271/7206	0.000134917894132
ko04730	Long-term depression	28/1291	78/7206	0.000142589256039
ko04010	MAPK signaling pathway	84/1291	321/7206	0.000181416145987
ko04974	Protein digestion and absorption	32/1291	96/7206	0.000237927215966
ko05414	Dilated cardiomyopathy	36/1291	112/7206	0.000253599850692
ko05161	Hepatitis B	14/1291	173/7206	0.000278140055322
ko04750	Inflammatory mediator regulation of TRP channels	38/1291	122/7206	0.000310596776395
ko05110	Vibrio cholerae infection	23/1291	63/7206	0.000393532230514
ko04612	Antigen processing and presentation	3/1291	77/7206	0.000447728221838
ko00520	Amino sugar and nucleotide sugar metabolism	1/1291	55/7206	0.000539600378376
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1291	182/7206	0.000579478347458
ko04210	Apoptosis	16/1291	180/7206	0.000766114990655
ko04640	Hematopoietic cell lineage	2/1291	64/7206	0.000785894880595
ko04217	Necroptosis	16/1291	178/7206	0.00101383355197
ko05166	HTLV-I infection	32/1291	292/7206	0.00103515366029
ko04371	Apelin signaling pathway	49/1291	177/7206	0.00137100812841
ko04014	Ras signaling pathway	71/1291	279/7206	0.00138055623588
ko04668	TNF signaling pathway	9/1291	120/7206	0.00163101903934
ko05215	Prostate cancer	8/1291	111/7206	0.0016761040407
ko04657	IL-17 signaling pathway	5/1291	87/7206	0.00168443697451
ko03420	Nucleotide excision repair	1/1291	46/7206	0.00178799151339
ko05140	Leishmaniasis	4/1291	75/7206	0.00220202058
ko03018	RNA degradation	5/1291	84/7206	0.0023421239711
ko04620	Toll-like receptor signaling pathway	7/1291	100/7206	0.00235936341209
ko00480	Glutathione metabolism	2/1291	55/7206	0.00242444268614
ko05321	Inflammatory bowel disease (IBD)	2/1291	56/7206	0.00244194647217
ko04072	Phospholipase D signaling pathway	52/1291	197/7206	0.00249669687944
ko04630	Jak-STAT signaling pathway	11/1291	132/7206	0.00267460963363
ko03022	Basal transcription factors	1/1291	44/7206	0.00269422459744
ko05144	Malaria	1/1291	45/7206	0.00273207738176
ko00071	Fatty acid degradation	1/1291	45/7206	0.00273207738176
ko04978	Mineral absorption	15/1291	40/7206	0.00298865254202
ko04214	Apoptosis - fly	4/1291	72/7206	0.00315184436403
ko05131	Shigellosis	5/1291	82/7206	0.00333198384574
ko04923	Regulation of lipolysis in adipocytes	24/1291	77/7206	0.00415336027276
ko04622	RIG-I-like receptor signaling pathway	3/1291	62/7206	0.00416487482263
ko04658	Th1 and Th2 cell differentiation	7/1291	96/7206	0.00450520812417
ko05145	Toxoplasmosis	11/1291	126/7206	0.00472854205173
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1291	100/7206	0.00558204332392
ko04070	Phosphatidylinositol signaling system	32/1291	112/7206	0.00580427479974
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1291	14/7206	0.00618782308449
ko01524	Platinum drug resistance	5/1291	76/7206	0.00644592692961
ko04922	Glucagon signaling pathway	35/1291	128/7206	0.0072318731432
ko04270	Vascular smooth muscle contraction	41/1291	154/7206	0.00751916524794
ko05219	Bladder cancer	2/1291	48/7206	0.0077450254855
ko04626	Plant-pathogen interaction	8/1291	18/7206	0.00829740641513
ko04933	AGE-RAGE signaling pathway in diabetic complications	13/1291	135/7206	0.00897861737118
ko04115	p53 signaling pathway	5/1291	74/7206	0.00900643095884
ko04140	Autophagy - animal	17/1291	164/7206	0.00968795250902
ko04218	Cellular senescence	19/1291	177/7206	0.00973190223168
ko04915	Estrogen signaling pathway	35/1291	131/7206	0.0110818568609
ko00240	Pyrimidine metabolism	10/1291	110/7206	0.0120439546716
ko00310	Lysine degradation	5/1291	73/7206	0.012953842523
ko00500	Starch and sucrose metabolism	1/1291	35/7206	0.0139801145458
ko05418	Fluid shear stress and atherosclerosis	19/1291	173/7206	0.0156133839071
ko04142	Lysosome	16/1291	151/7206	0.0177669622633
ko00330	Arginine and proline metabolism	4/1291	61/7206	0.0178432045215
ko00290	Valine, leucine and isoleucine biosynthesis	3/1291	4/7206	0.019878757849
ko05212	Pancreatic cancer	7/1291	83/7206	0.0207998047561
ko04918	Thyroid hormone synthesis	24/1291	86/7206	0.0224581812866
ko05132	Salmonella infection	9/1291	98/7206	0.0232856414617
ko04146	Peroxisome	8/1291	89/7206	0.0254935031051
ko04930	Type II diabetes mellitus	16/1291	54/7206	0.0315895014959
ko01200	Carbon metabolism	14/1291	128/7206	0.0362684377188
ko05206	MicroRNAs in cancer	21/1291	177/7206	0.0365489769025
ko05016	Huntington's disease	27/1291	215/7206	0.0376544073927
ko03015	mRNA surveillance pathway	9/1291	93/7206	0.0401238547913
ko04113	Meiosis - yeast	6/1291	70/7206	0.0409650408072
ko04912	GnRH signaling pathway	31/1291	122/7206	0.041872836036
ko00600	Sphingolipid metabolism	5/1291	63/7206	0.0455855679362
ko04916	Melanogenesis	35/1291	142/7206	0.0457230728357
ko00280	Valine, leucine and isoleucine degradation	4/1291	54/7206	0.0481940840737
ko05320	Autoimmune thyroid disease	1/1291	29/7206	0.0482652850933