ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 37/447 152/7206 2.17588748688e-13 ko04713 Circadian entrainment 33/447 136/7206 5.03390471361e-12 ko04911 Insulin secretion 28/447 117/7206 3.09179197635e-10 ko05031 Amphetamine addiction 24/447 91/7206 7.0406290388e-10 ko05033 Nicotine addiction 18/447 56/7206 3.11155935451e-09 ko04720 Long-term potentiation 24/447 99/7206 4.48205867791e-09 ko04728 Dopaminergic synapse 34/447 185/7206 6.84023896652e-09 ko04020 Calcium signaling pathway 40/447 265/7206 1.3351736257e-07 ko04921 Oxytocin signaling pathway 34/447 209/7206 1.58577324501e-07 ko05032 Morphine addiction 23/447 110/7206 1.81354405541e-07 ko04725 Cholinergic synapse 28/447 160/7206 4.42012797999e-07 ko04024 cAMP signaling pathway 40/447 279/7206 6.65058594229e-07 ko04727 GABAergic synapse 22/447 110/7206 7.56660157606e-07 ko04744 Phototransduction 12/447 36/7206 8.93812199167e-07 ko04360 Axon guidance 34/447 233/7206 2.4029445148e-06 ko04723 Retrograde endocannabinoid signaling 28/447 175/7206 2.8460485069e-06 ko04080 Neuroactive ligand-receptor interaction 51/447 423/7206 3.32017763227e-06 ko04745 Phototransduction - fly 11/447 38/7206 1.2057445565e-05 ko04070 Phosphatidylinositol signaling system 20/447 112/7206 1.46781317298e-05 ko04925 Aldosterone synthesis and secretion 19/447 105/7206 1.97411621285e-05 ko04261 Adrenergic signaling in cardiomyocytes 29/447 205/7206 2.40244549404e-05 ko04726 Serotonergic synapse 22/447 137/7206 3.15107224619e-05 ko04721 Synaptic vesicle cycle 15/447 80/7206 9.6726787046e-05 ko04970 Salivary secretion 16/447 95/7206 0.000213760017714 ko04710 Circadian rhythm 10/447 43/7206 0.000228598289317 ko04971 Gastric acid secretion 16/447 98/7206 0.000309059364683 ko04740 Olfactory transduction 14/447 80/7206 0.000349664750814 ko04022 cGMP-PKG signaling pathway 27/447 216/7206 0.000453043234229 ko04010 MAPK signaling pathway 36/447 321/7206 0.000502203053414 ko05014 Amyotrophic lateral sclerosis (ALS) 13/447 74/7206 0.000543460312938 ko04514 Cell adhesion molecules (CAMs) 19/447 130/7206 0.000606568181595 ko05203 Viral carcinogenesis 5/447 277/7206 0.000807223680144 ko04922 Glucagon signaling pathway 18/447 128/7206 0.00111932586506 ko03040 Spliceosome 1/447 145/7206 0.00149401488771 ko04964 Proximal tubule bicarbonate reclamation 7/447 29/7206 0.00159224280734 ko05030 Cocaine addiction 12/447 73/7206 0.00161076710989 ko04750 Inflammatory mediator regulation of TRP channels 17/447 122/7206 0.00170014821094 ko04730 Long-term depression 12/447 78/7206 0.00287271119881 ko00562 Inositol phosphate metabolism 13/447 89/7206 0.00312522084822 ko04060 Cytokine-cytokine receptor interaction 3/447 191/7206 0.00346654105226 ko04626 Plant-pathogen interaction 5/447 18/7206 0.00391815657931 ko04972 Pancreatic secretion 15/447 111/7206 0.00414974506859 ko03010 Ribosome 1/447 129/7206 0.00476403178047 ko04072 Phospholipase D signaling pathway 22/447 197/7206 0.00645566610228 ko05162 Measles 1/447 120/7206 0.00678277402014 ko04260 Cardiac muscle contraction 13/447 98/7206 0.00899825803588 ko02010 ABC transporters 7/447 39/7206 0.00917956793459 ko05224 Breast cancer 3/447 174/7206 0.00976103673544 ko04960 Aldosterone-regulated sodium reabsorption 7/447 41/7206 0.0120621128186 ko04550 Signaling pathways regulating pluripotency of stem cells 3/447 165/7206 0.0132795814994 ko03013 RNA transport 3/447 166/7206 0.0133813358799 ko05164 Influenza A 3/447 167/7206 0.0135207867001 ko00680 Methane metabolism 6/447 34/7206 0.0167997009173 ko04930 Type II diabetes mellitus 8/447 54/7206 0.0172647253004 ko05169 Epstein-Barr virus infection 5/447 206/7206 0.0182764157441 ko04114 Oocyte meiosis 16/447 139/7206 0.018632531837 ko05168 Herpes simplex infection 4/447 182/7206 0.0186331185655 ko00471 D-Glutamine and D-glutamate metabolism 2/447 4/7206 0.0211854181072 ko00290 Valine, leucine and isoleucine biosynthesis 2/447 4/7206 0.0211854181072 ko04014 Ras signaling pathway 27/447 279/7206 0.0216030817716 ko00010 Glycolysis / Gluconeogenesis 10/447 74/7206 0.0238924908918 ko04012 ErbB signaling pathway 13/447 109/7206 0.0242472783151 ko05166 HTLV-I infection 9/447 292/7206 0.0246877263644 ko04722 Neurotrophin signaling pathway 17/447 160/7206 0.029037918696 ko05214 Glioma 10/447 79/7206 0.0296001527601 ko04110 Cell cycle 3/447 145/7206 0.035069206706 ko04978 Mineral absorption 6/447 40/7206 0.035129418343 ko05010 Alzheimer's disease 20/447 202/7206 0.0366833070144 ko05200 Pathways in cancer 20/447 492/7206 0.0416528330473 ko04711 Circadian rhythm - fly 3/447 13/7206 0.042554525141 ko04657 IL-17 signaling pathway 1/447 87/7206 0.0431729372771 ko00051 Fructose and mannose metabolism 6/447 42/7206 0.0433102363692 ko04141 Protein processing in endoplasmic reticulum 5/447 184/7206 0.0437321440964 ko04940 Type I diabetes mellitus 5/447 32/7206 0.0452050050756