ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	195/1169	423/7206	1.13592907402e-50
ko04724	Glutamatergic synapse	89/1169	152/7206	3.81538767099e-33
ko05033	Nicotine addiction	48/1169	56/7206	2.00785828584e-30
ko05032	Morphine addiction	68/1169	110/7206	1.61249508723e-27
ko04713	Circadian entrainment	74/1169	136/7206	6.23322879293e-25
ko04727	GABAergic synapse	65/1169	110/7206	9.282426359e-25
ko04721	Synaptic vesicle cycle	52/1169	80/7206	8.83593478432e-23
ko04728	Dopaminergic synapse	83/1169	185/7206	1.28910987974e-20
ko04725	Cholinergic synapse	74/1169	160/7206	1.96119823471e-19
ko04024	cAMP signaling pathway	105/1169	279/7206	1.10879734689e-18
ko04723	Retrograde endocannabinoid signaling	77/1169	175/7206	1.39076339614e-18
ko04020	Calcium signaling pathway	100/1169	265/7206	7.62298085726e-18
ko04742	Taste transduction	39/1169	61/7206	5.14281886316e-17
ko04921	Oxytocin signaling pathway	79/1169	209/7206	1.95385412646e-14
ko04726	Serotonergic synapse	58/1169	137/7206	2.15087622355e-13
ko04911	Insulin secretion	52/1169	117/7206	3.78601683582e-13
ko04261	Adrenergic signaling in cardiomyocytes	73/1169	205/7206	6.79766518246e-12
ko04744	Phototransduction	24/1169	36/7206	1.54518143383e-11
ko04970	Salivary secretion	42/1169	95/7206	8.84112174773e-11
ko04720	Long-term potentiation	43/1169	99/7206	1.0653534306e-10
ko05031	Amphetamine addiction	40/1169	91/7206	3.09113688292e-10
ko03040	Spliceosome	1/1169	145/7206	3.19999294633e-10
ko04360	Axon guidance	71/1169	233/7206	3.4762601816e-08
ko05203	Viral carcinogenesis	15/1169	277/7206	4.17291799512e-08
ko04971	Gastric acid secretion	37/1169	98/7206	2.14120681e-07
ko04060	Cytokine-cytokine receptor interaction	8/1169	191/7206	2.48742109261e-07
ko04022	cGMP-PKG signaling pathway	65/1169	216/7206	2.60560536221e-07
ko04925	Aldosterone synthesis and secretion	38/1169	105/7206	6.1749779462e-07
ko05030	Cocaine addiction	29/1169	73/7206	1.16840138236e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1169	74/7206	1.62806204604e-06
ko04966	Collecting duct acid secretion	15/1169	26/7206	1.70051447695e-06
ko03013	RNA transport	7/1169	166/7206	1.89221264017e-06
ko05164	Influenza A	7/1169	167/7206	1.92561105877e-06
ko04924	Renin secretion	32/1169	86/7206	2.05521866791e-06
ko05322	Systemic lupus erythematosus	6/1169	151/7206	3.32460062575e-06
ko05168	Herpes simplex infection	9/1169	182/7206	3.42851841863e-06
ko04740	Olfactory transduction	30/1169	80/7206	3.83327363365e-06
ko04010	MAPK signaling pathway	82/1169	321/7206	1.24106478342e-05
ko04610	Complement and coagulation cascades	1/1169	79/7206	2.0398714962e-05
ko05169	Epstein-Barr virus infection	13/1169	206/7206	2.07237232781e-05
ko04514	Cell adhesion molecules (CAMs)	40/1169	130/7206	3.18254133604e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1169	79/7206	3.59774863944e-05
ko04260	Cardiac muscle contraction	32/1169	98/7206	4.66563597207e-05
ko04972	Pancreatic secretion	35/1169	111/7206	6.93965085854e-05
ko05414	Dilated cardiomyopathy	35/1169	112/7206	7.55202078135e-05
ko05110	Vibrio cholerae infection	23/1169	63/7206	8.59172167403e-05
ko04120	Ubiquitin mediated proteolysis	7/1169	138/7206	9.45397494237e-05
ko04976	Bile secretion	27/1169	80/7206	9.67832583781e-05
ko04141	Protein processing in endoplasmic reticulum	12/1169	184/7206	0.000101681494553
ko04621	NOD-like receptor signaling pathway	9/1169	157/7206	0.00010376585823
ko04745	Phototransduction - fly	16/1169	38/7206	0.000131358626111
ko04540	Gap junction	38/1169	128/7206	0.000136234360185
ko04070	Phosphatidylinositol signaling system	34/1169	112/7206	0.000149386857044
ko03008	Ribosome biogenesis in eukaryotes	2/1169	79/7206	0.00017205850532
ko05205	Proteoglycans in cancer	23/1169	271/7206	0.000204020619582
ko05161	Hepatitis B	12/1169	173/7206	0.000347232100417
ko04110	Cell cycle	9/1169	145/7206	0.000374085865031
ko05140	Leishmaniasis	2/1169	75/7206	0.000389111534769
ko04064	NF-kappa B signaling pathway	4/1169	96/7206	0.000404422743135
ko04730	Long-term depression	25/1169	78/7206	0.0005088441585
ko04014	Ras signaling pathway	67/1169	279/7206	0.000637896402397
ko04371	Apelin signaling pathway	46/1169	177/7206	0.000856773014744
ko04626	Plant-pathogen interaction	9/1169	18/7206	0.000909020021844
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1169	59/7206	0.000998129198226
ko05162	Measles	7/1169	120/7206	0.00100623408181
ko04964	Proximal tubule bicarbonate reclamation	12/1169	29/7206	0.00109674488814
ko04750	Inflammatory mediator regulation of TRP channels	34/1169	122/7206	0.00110736526162
ko04146	Peroxisome	4/1169	89/7206	0.00121504351835
ko04612	Antigen processing and presentation	3/1169	77/7206	0.00154416853572
ko04072	Phospholipase D signaling pathway	49/1169	197/7206	0.00159582289732
ko04630	Jak-STAT signaling pathway	9/1169	132/7206	0.00179294882432
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1169	100/7206	0.00246151629495
ko00330	Arginine and proline metabolism	2/1169	61/7206	0.00266077479051
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1169	14/7206	0.00347439124307
ko04915	Estrogen signaling pathway	34/1169	131/7206	0.00386429403809
ko03420	Nucleotide excision repair	1/1169	46/7206	0.00444199219096
ko05321	Inflammatory bowel disease (IBD)	2/1169	56/7206	0.00571966804281
ko03022	Basal transcription factors	1/1169	44/7206	0.00668363368176
ko05144	Malaria	1/1169	45/7206	0.00690409362169
ko00071	Fatty acid degradation	1/1169	45/7206	0.00690409362169
ko03018	RNA degradation	5/1169	84/7206	0.00696884220973
ko04923	Regulation of lipolysis in adipocytes	22/1169	77/7206	0.00730122642049
ko05166	HTLV-I infection	31/1169	292/7206	0.00730249995781
ko00480	Glutathione metabolism	2/1169	55/7206	0.00873920288395
ko04640	Hematopoietic cell lineage	3/1169	64/7206	0.00948989108064
ko05131	Shigellosis	5/1169	82/7206	0.00972109718591
ko00310	Lysine degradation	4/1169	73/7206	0.00977254068958
ko05145	Toxoplasmosis	10/1169	126/7206	0.00988494379818
ko04270	Vascular smooth muscle contraction	37/1169	154/7206	0.0107775979522
ko00590	Arachidonic acid metabolism	2/1169	52/7206	0.0124883145143
ko04622	RIG-I-like receptor signaling pathway	3/1169	62/7206	0.0138386720206
ko00630	Glyoxylate and dicarboxylate metabolism	1/1169	38/7206	0.0149850924759
ko03410	Base excision repair	1/1169	38/7206	0.0149850924759
ko04658	Th1 and Th2 cell differentiation	7/1169	96/7206	0.0167850881304
ko05219	Bladder cancer	2/1169	48/7206	0.0176430543692
ko04657	IL-17 signaling pathway	6/1169	87/7206	0.0180111682263
ko05133	Pertussis	6/1169	87/7206	0.0180111682263
ko00240	Pyrimidine metabolism	9/1169	110/7206	0.0185720433596
ko00380	Tryptophan metabolism	2/1169	50/7206	0.0185971250786
ko05215	Prostate cancer	9/1169	111/7206	0.0187212347654
ko04115	p53 signaling pathway	5/1169	74/7206	0.0253311649418
ko04930	Type II diabetes mellitus	15/1169	54/7206	0.0262833338288
ko04620	Toll-like receptor signaling pathway	8/1169	100/7206	0.0275791508954
ko04916	Melanogenesis	33/1169	142/7206	0.0282666740537
ko05222	Small cell lung cancer	7/1169	89/7206	0.029450816257
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1169	92/7206	0.0313427957985
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1169	182/7206	0.0320818377931
ko04668	TNF signaling pathway	11/1169	120/7206	0.0333866717033
ko04933	AGE-RAGE signaling pathway in diabetic complications	13/1169	135/7206	0.0338370782788
ko04912	GnRH signaling pathway	29/1169	122/7206	0.0341129235407
ko00500	Starch and sucrose metabolism	1/1169	35/7206	0.0346535557504
ko04214	Apoptosis - fly	5/1169	72/7206	0.0349739102383
ko00561	Glycerolipid metabolism	4/1169	63/7206	0.0372358766309
ko00280	Valine, leucine and isoleucine degradation	3/1169	54/7206	0.0388066568646
ko04217	Necroptosis	19/1169	178/7206	0.0397262005496
ko04210	Apoptosis	19/1169	180/7206	0.0399157551842
ko04140	Autophagy - animal	17/1169	164/7206	0.0412409884165
ko04711	Circadian rhythm - fly	5/1169	13/7206	0.0460355634797
ko03320	PPAR signaling pathway	5/1169	69/7206	0.0471488605349
ko05206	MicroRNAs in cancer	19/1169	177/7206	0.0491643679538