ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	164/963	423/7206	4.07954499437e-42
ko04724	Glutamatergic synapse	80/963	152/7206	1.49878204454e-31
ko05032	Morphine addiction	65/963	110/7206	9.29373900255e-30
ko05033	Nicotine addiction	44/963	56/7206	1.63281243124e-28
ko04727	GABAergic synapse	62/963	110/7206	7.76471954786e-27
ko04728	Dopaminergic synapse	82/963	185/7206	1.15304631053e-25
ko04713	Circadian entrainment	68/963	136/7206	3.26169107648e-25
ko04721	Synaptic vesicle cycle	50/963	80/7206	1.03108816854e-24
ko04725	Cholinergic synapse	72/963	160/7206	4.05509624818e-23
ko04723	Retrograde endocannabinoid signaling	74/963	175/7206	9.97089034236e-22
ko04024	cAMP signaling pathway	90/963	279/7206	7.50760508018e-17
ko04911	Insulin secretion	52/963	117/7206	1.04151139902e-16
ko04742	Taste transduction	33/963	61/7206	3.9264612545e-14
ko04726	Serotonergic synapse	53/963	137/7206	6.17331981628e-14
ko04261	Adrenergic signaling in cardiomyocytes	68/963	205/7206	1.21035101012e-13
ko04921	Oxytocin signaling pathway	69/963	209/7206	1.62267887169e-13
ko05031	Amphetamine addiction	39/963	91/7206	3.13076565431e-12
ko04020	Calcium signaling pathway	77/963	265/7206	8.49199881782e-12
ko04720	Long-term potentiation	39/963	99/7206	7.14092395905e-11
ko04925	Aldosterone synthesis and secretion	38/963	105/7206	2.22328813908e-09
ko04744	Phototransduction	20/963	36/7206	2.4071561776e-09
ko04970	Salivary secretion	34/963	95/7206	2.16718062828e-08
ko03040	Spliceosome	1/963	145/7206	3.7397189102e-08
ko04971	Gastric acid secretion	34/963	98/7206	5.28773831602e-08
ko05030	Cocaine addiction	27/963	73/7206	2.85366252949e-07
ko04010	MAPK signaling pathway	76/963	321/7206	3.33527280348e-07
ko04966	Collecting duct acid secretion	14/963	26/7206	1.07002423176e-06
ko04740	Olfactory transduction	27/963	80/7206	2.30799789507e-06
ko05110	Vibrio cholerae infection	23/963	63/7206	2.8157221898e-06
ko05203	Viral carcinogenesis	14/963	277/7206	5.53303594071e-06
ko04120	Ubiquitin mediated proteolysis	3/963	138/7206	6.46871607215e-06
ko04060	Cytokine-cytokine receptor interaction	7/963	191/7206	7.53016509057e-06
ko03013	RNA transport	5/963	166/7206	7.83950989197e-06
ko04360	Axon guidance	56/963	233/7206	7.89554766614e-06
ko05322	Systemic lupus erythematosus	4/963	151/7206	8.93389163234e-06
ko04745	Phototransduction - fly	16/963	38/7206	1.13823837223e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/963	59/7206	1.20186861461e-05
ko04972	Pancreatic secretion	32/963	111/7206	1.4562033278e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	24/963	74/7206	1.80299075982e-05
ko05168	Herpes simplex infection	7/963	182/7206	2.14005500683e-05
ko04621	NOD-like receptor signaling pathway	5/963	157/7206	2.35232973752e-05
ko04260	Cardiac muscle contraction	29/963	98/7206	3.00767305625e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/963	79/7206	3.07599717251e-05
ko04514	Cell adhesion molecules (CAMs)	35/963	130/7206	3.64718781077e-05
ko04022	cGMP-PKG signaling pathway	51/963	216/7206	3.84636072193e-05
ko04730	Long-term depression	24/963	78/7206	6.07632669707e-05
ko04141	Protein processing in endoplasmic reticulum	8/963	184/7206	6.40251850938e-05
ko04072	Phospholipase D signaling pathway	46/963	197/7206	0.00010978582592
ko04915	Estrogen signaling pathway	33/963	131/7206	0.000227638635996
ko04014	Ras signaling pathway	59/963	279/7206	0.000296539281278
ko04924	Renin secretion	24/963	86/7206	0.000318436122165
ko03008	Ribosome biogenesis in eukaryotes	1/963	79/7206	0.000324089024636
ko05164	Influenza A	8/963	167/7206	0.000329090011458
ko04976	Bile secretion	23/963	80/7206	0.000345533078335
ko05414	Dilated cardiomyopathy	29/963	112/7206	0.00035674724707
ko04070	Phosphatidylinositol signaling system	29/963	112/7206	0.00035674724707
ko04750	Inflammatory mediator regulation of TRP channels	30/963	122/7206	0.000677368139673
ko04371	Apelin signaling pathway	40/963	177/7206	0.000692741421508
ko04540	Gap junction	31/963	128/7206	0.000872175437135
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/963	14/7206	0.00108589347138
ko04064	NF-kappa B signaling pathway	3/963	96/7206	0.00125591844776
ko04612	Antigen processing and presentation	2/963	77/7206	0.0021238735449
ko04964	Proximal tubule bicarbonate reclamation	10/963	29/7206	0.00313701615457
ko05140	Leishmaniasis	2/963	75/7206	0.00313995879589
ko05162	Measles	6/963	120/7206	0.00415847802588
ko00240	Pyrimidine metabolism	5/963	110/7206	0.00422125313233
ko05205	Proteoglycans in cancer	21/963	271/7206	0.00459690839219
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/963	92/7206	0.00509251032362
ko04626	Plant-pathogen interaction	7/963	18/7206	0.00620294540301
ko05169	Epstein-Barr virus infection	15/963	206/7206	0.00680814003465
ko04912	GnRH signaling pathway	27/963	122/7206	0.00683718961959
ko05410	Hypertrophic cardiomyopathy (HCM)	23/963	100/7206	0.00726418625405
ko00480	Glutathione metabolism	1/963	55/7206	0.00801513528875
ko04110	Cell cycle	9/963	145/7206	0.00904373067345
ko04640	Hematopoietic cell lineage	2/963	64/7206	0.0094212124302
ko04146	Peroxisome	4/963	89/7206	0.0110708829359
ko04270	Vascular smooth muscle contraction	32/963	154/7206	0.011261783767
ko00590	Arachidonic acid metabolism	1/963	52/7206	0.0119028091537
ko00330	Arginine and proline metabolism	2/963	61/7206	0.0135721160838
ko04210	Apoptosis	13/963	180/7206	0.0140483963806
ko00310	Lysine degradation	3/963	73/7206	0.0147229358656
ko03018	RNA degradation	4/963	84/7206	0.0150401603752
ko04015	Rap1 signaling pathway	51/963	278/7206	0.015196502123
ko00260	Glycine, serine and threonine metabolism	1/963	48/7206	0.0169522904124
ko05219	Bladder cancer	1/963	48/7206	0.0169522904124
ko04916	Melanogenesis	29/963	142/7206	0.0173502403398
ko04214	Apoptosis - fly	3/963	72/7206	0.0216057076164
ko04114	Oocyte meiosis	28/963	139/7206	0.0229190050803
ko05161	Hepatitis B	13/963	173/7206	0.0229226288754
ko04918	Thyroid hormone synthesis	19/963	86/7206	0.0242445819458
ko03022	Basal transcription factors	1/963	44/7206	0.0245655125338
ko05144	Malaria	1/963	45/7206	0.0250867730425
ko00071	Fatty acid degradation	1/963	45/7206	0.0250867730425
ko05034	Alcoholism	44/963	238/7206	0.0252612968877
ko04217	Necroptosis	14/963	178/7206	0.0257176268669
ko03420	Nucleotide excision repair	1/963	46/7206	0.0261131353664
ko04062	Chemokine signaling pathway	38/963	201/7206	0.0265237648516
ko04930	Type II diabetes mellitus	13/963	54/7206	0.0268563553352
ko04630	Jak-STAT signaling pathway	9/963	132/7206	0.0270835878395
ko05321	Inflammatory bowel disease (IBD)	2/963	56/7206	0.0281853345584
ko04658	Th1 and Th2 cell differentiation	6/963	96/7206	0.0347420967235
ko00980	Metabolism of xenobiotics by cytochrome P450	1/963	40/7206	0.0361384443622
ko00140	Steroid hormone biosynthesis	1/963	41/7206	0.0362448469273
ko00983	Drug metabolism - other enzymes	1/963	42/7206	0.0370514911907
ko04657	IL-17 signaling pathway	5/963	87/7206	0.0376702933283
ko05323	Rheumatoid arthritis	19/963	89/7206	0.0394608173308
ko01524	Platinum drug resistance	4/963	76/7206	0.0399402684911
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/963	15/7206	0.0399905145584
ko00561	Glycerolipid metabolism	3/963	63/7206	0.0404658570441
ko04923	Regulation of lipolysis in adipocytes	17/963	77/7206	0.0408640505515
ko00280	Valine, leucine and isoleucine degradation	2/963	54/7206	0.0413562535117
ko05214	Glioma	17/963	79/7206	0.0439363943858
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/963	182/7206	0.0460181310077
ko04722	Neurotrophin signaling pathway	30/963	160/7206	0.0461213058583
ko00512	Mucin type O-glycan biosynthesis	8/963	29/7206	0.0475772329698
ko04922	Glucagon signaling pathway	25/963	128/7206	0.0481272881772