ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 95/459 145/7206 2.4474843027e-80 ko03013 RNA transport 50/459 166/7206 1.23907883048e-21 ko03030 DNA replication 22/459 38/7206 2.5883482061e-17 ko03015 mRNA surveillance pathway 28/459 93/7206 1.4026989978e-12 ko03410 Base excision repair 18/459 38/7206 2.20237838687e-12 ko04110 Cell cycle 35/459 145/7206 2.82920231756e-12 ko04111 Cell cycle - yeast 27/459 90/7206 3.92049511691e-12 ko00240 Pyrimidine metabolism 29/459 110/7206 2.18258218524e-11 ko03008 Ribosome biogenesis in eukaryotes 24/459 79/7206 4.71118330245e-11 ko05168 Herpes simplex infection 35/459 182/7206 2.34111826269e-09 ko03022 Basal transcription factors 16/459 44/7206 4.49434236399e-09 ko03420 Nucleotide excision repair 16/459 46/7206 9.49265538949e-09 ko03430 Mismatch repair 11/459 22/7206 2.31375166752e-08 ko03018 RNA degradation 21/459 84/7206 3.73693950282e-08 ko03020 RNA polymerase 12/459 29/7206 7.41938284478e-08 ko05169 Epstein-Barr virus infection 34/459 206/7206 2.09455962148e-07 ko04113 Meiosis - yeast 16/459 70/7206 5.70176609488e-06 ko04120 Ubiquitin mediated proteolysis 23/459 138/7206 1.71651276141e-05 ko04072 Phospholipase D signaling pathway 1/459 197/7206 4.5844727611e-05 ko04360 Axon guidance 2/459 233/7206 5.2139107845e-05 ko04014 Ras signaling pathway 4/459 279/7206 0.00013311670263 ko03440 Homologous recombination 10/459 41/7206 0.000186032862437 ko04921 Oxytocin signaling pathway 2/459 209/7206 0.000237442109852 ko04810 Regulation of actin cytoskeleton 4/459 264/7206 0.000258181529299 ko03460 Fanconi anemia pathway 11/459 51/7206 0.000288512124402 ko05010 Alzheimer's disease 2/459 202/7206 0.000339267539073 ko04024 cAMP signaling pathway 5/459 279/7206 0.000402964758718 ko04015 Rap1 signaling pathway 5/459 278/7206 0.000403204455366 ko04712 Circadian rhythm - plant 4/459 7/7206 0.000487288684652 ko04022 cGMP-PKG signaling pathway 3/459 216/7206 0.000608149792856 ko05012 Parkinson's disease 1/459 155/7206 0.000693275325797 ko04621 NOD-like receptor signaling pathway 1/459 157/7206 0.000709352459597 ko04724 Glutamatergic synapse 1/459 152/7206 0.00106576463395 ko04723 Retrograde endocannabinoid signaling 2/459 175/7206 0.00143336088625 ko00230 Purine metabolism 24/459 194/7206 0.00150609807705 ko04010 MAPK signaling pathway 8/459 321/7206 0.00213529505693 ko04726 Serotonergic synapse 1/459 137/7206 0.00219176207338 ko04725 Cholinergic synapse 2/459 160/7206 0.0029185160073 ko04145 Phagosome 2/459 162/7206 0.00293824129958 ko04915 Estrogen signaling pathway 1/459 131/7206 0.00321032372152 ko04151 PI3K-Akt signaling pathway 12/459 390/7206 0.00387714415925 ko04270 Vascular smooth muscle contraction 2/459 154/7206 0.00417022222878 ko04912 GnRH signaling pathway 1/459 122/7206 0.00463040256217 ko05145 Toxoplasmosis 1/459 126/7206 0.00476461322641 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/459 182/7206 0.00494957195255 ko01200 Carbon metabolism 1/459 128/7206 0.00496980082322 ko04911 Insulin secretion 1/459 117/7206 0.0067501250427 ko04371 Apelin signaling pathway 3/459 177/7206 0.00707995686406 ko04062 Chemokine signaling pathway 4/459 201/7206 0.00748403188501 ko04139 Mitophagy - yeast 7/459 37/7206 0.00787836795922 ko04727 GABAergic synapse 1/459 110/7206 0.00980152456005 ko05032 Morphine addiction 1/459 110/7206 0.00980152456005 ko04510 Focal adhesion 6/459 240/7206 0.00989213186306 ko04218 Cellular senescence 20/459 177/7206 0.0115826658986 ko04713 Circadian entrainment 2/459 136/7206 0.0120413353388 ko04659 Th17 cell differentiation 1/459 106/7206 0.0144163766032 ko05200 Pathways in cancer 19/459 492/7206 0.016486413252 ko03010 Ribosome 2/459 129/7206 0.0169905584029 ko05142 Chagas disease (American trypanosomiasis) 2/459 130/7206 0.0170787716364 ko04530 Tight junction 6/459 228/7206 0.0179399954265 ko04261 Adrenergic signaling in cardiomyocytes 5/459 205/7206 0.0188410585338 ko05166 HTLV-I infection 29/459 292/7206 0.0191254849615 ko04114 Oocyte meiosis 16/459 139/7206 0.0205455948437 ko04650 Natural killer cell mediated cytotoxicity 1/459 97/7206 0.0206170386123 ko04660 T cell receptor signaling pathway 2/459 124/7206 0.0241669992828 ko04658 Th1 and Th2 cell differentiation 1/459 96/7206 0.0314369687443 ko05152 Tuberculosis 5/459 187/7206 0.032772096208 ko04611 Platelet activation 4/459 163/7206 0.0341739253022 ko04140 Autophagy - animal 4/459 164/7206 0.0342639445359 ko04668 TNF signaling pathway 2/459 120/7206 0.0349496540879 ko05205 Proteoglycans in cancer 9/459 271/7206 0.0410221037083 ko01230 Biosynthesis of amino acids 1/459 85/7206 0.0430447180794 ko04924 Renin secretion 1/459 86/7206 0.0432270230129 ko04918 Thyroid hormone synthesis 1/459 86/7206 0.0432270230129 ko05133 Pertussis 1/459 87/7206 0.0435740556678 ko04662 B cell receptor signaling pathway 1/459 88/7206 0.0440851392184 ko04146 Peroxisome 1/459 89/7206 0.0447597107646 ko04012 ErbB signaling pathway 2/459 109/7206 0.0471281935572 ko04630 Jak-STAT signaling pathway 3/459 132/7206 0.0475664991792 ko04972 Pancreatic secretion 2/459 111/7206 0.047567717989 ko04380 Osteoclast differentiation 3/459 134/7206 0.0477786351709 ko05231 Choline metabolism in cancer 3/459 134/7206 0.0477786351709 ko04933 AGE-RAGE signaling pathway in diabetic complications 3/459 135/7206 0.0480560544957