ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	204/1249	423/7206	4.23722928264e-52
ko04724	Glutamatergic synapse	89/1249	152/7206	7.52958651407e-31
ko05033	Nicotine addiction	46/1249	56/7206	2.86575994747e-26
ko05032	Morphine addiction	68/1249	110/7206	9.53328672724e-26
ko04727	GABAergic synapse	65/1249	110/7206	4.27884252446e-23
ko04713	Circadian entrainment	74/1249	136/7206	4.31302010579e-23
ko04721	Synaptic vesicle cycle	51/1249	80/7206	1.8455010239e-20
ko04728	Dopaminergic synapse	85/1249	185/7206	5.58654193806e-20
ko04725	Cholinergic synapse	77/1249	160/7206	1.08152338439e-19
ko04024	cAMP signaling pathway	108/1249	279/7206	5.74705380764e-18
ko04020	Calcium signaling pathway	104/1249	265/7206	7.09335770601e-18
ko04726	Serotonergic synapse	65/1249	137/7206	2.08795925169e-16
ko04723	Retrograde endocannabinoid signaling	76/1249	175/7206	2.89346589433e-16
ko04911	Insulin secretion	56/1249	117/7206	1.63668885358e-14
ko04921	Oxytocin signaling pathway	81/1249	209/7206	1.17078080151e-13
ko04742	Taste transduction	36/1249	61/7206	2.56032680466e-13
ko04970	Salivary secretion	44/1249	95/7206	4.46588255807e-11
ko04744	Phototransduction	24/1249	36/7206	6.60067502597e-11
ko04261	Adrenergic signaling in cardiomyocytes	72/1249	205/7206	4.6423828848e-10
ko05031	Amphetamine addiction	41/1249	91/7206	5.92969445072e-10
ko03040	Spliceosome	2/1249	145/7206	5.9687764984e-10
ko04720	Long-term potentiation	43/1249	99/7206	9.35828169843e-10
ko03010	Ribosome	1/1249	129/7206	9.36169331972e-10
ko04022	cGMP-PKG signaling pathway	70/1249	216/7206	4.2617741516e-08
ko05168	Herpes simplex infection	8/1249	182/7206	1.47616262829e-07
ko05203	Viral carcinogenesis	19/1249	277/7206	3.77946977326e-07
ko03013	RNA transport	7/1249	166/7206	3.78721334745e-07
ko04740	Olfactory transduction	33/1249	80/7206	5.93340828972e-07
ko05322	Systemic lupus erythematosus	6/1249	151/7206	6.51287684183e-07
ko04971	Gastric acid secretion	37/1249	98/7206	1.18671799367e-06
ko04925	Aldosterone synthesis and secretion	39/1249	105/7206	1.34905844642e-06
ko04360	Axon guidance	70/1249	233/7206	1.47066028188e-06
ko04966	Collecting duct acid secretion	15/1249	26/7206	4.03472136915e-06
ko05030	Cocaine addiction	29/1249	73/7206	5.52052059112e-06
ko04730	Long-term depression	30/1249	78/7206	7.30451945166e-06
ko04924	Renin secretion	32/1249	86/7206	9.23451573215e-06
ko04060	Cytokine-cytokine receptor interaction	12/1249	191/7206	9.91199565729e-06
ko05164	Influenza A	10/1249	167/7206	1.79385194883e-05
ko04120	Ubiquitin mediated proteolysis	7/1249	138/7206	2.08108399068e-05
ko04070	Phosphatidylinositol signaling system	38/1249	112/7206	2.14440583878e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1249	74/7206	3.18720711343e-05
ko04110	Cell cycle	8/1249	145/7206	3.21843551417e-05
ko04972	Pancreatic secretion	37/1249	111/7206	3.72989978761e-05
ko04976	Bile secretion	29/1249	80/7206	4.08335433783e-05
ko04540	Gap junction	41/1249	128/7206	4.55313183259e-05
ko04014	Ras signaling pathway	75/1249	279/7206	4.85853729398e-05
ko04514	Cell adhesion molecules (CAMs)	41/1249	130/7206	5.78812304159e-05
ko04621	NOD-like receptor signaling pathway	10/1249	157/7206	6.78929029356e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1249	79/7206	7.02406354714e-05
ko05169	Epstein-Barr virus infection	16/1249	206/7206	7.93015154127e-05
ko04010	MAPK signaling pathway	83/1249	321/7206	8.13084640069e-05
ko04964	Proximal tubule bicarbonate reclamation	14/1249	29/7206	0.000119299915128
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1249	79/7206	0.000121514698158
ko04745	Phototransduction - fly	16/1249	38/7206	0.000291639723955
ko05414	Dilated cardiomyopathy	35/1249	112/7206	0.000341944194754
ko04072	Phospholipase D signaling pathway	54/1249	197/7206	0.000369516058396
ko04750	Inflammatory mediator regulation of TRP channels	37/1249	122/7206	0.000389867032043
ko04923	Regulation of lipolysis in adipocytes	26/1249	77/7206	0.000403401572965
ko04141	Protein processing in endoplasmic reticulum	15/1249	184/7206	0.000495618287904
ko04371	Apelin signaling pathway	49/1249	177/7206	0.000561453464292
ko04064	NF-kappa B signaling pathway	5/1249	96/7206	0.000597180007537
ko04260	Cardiac muscle contraction	31/1249	98/7206	0.000632069633095
ko05110	Vibrio cholerae infection	22/1249	63/7206	0.000655520000166
ko04612	Antigen processing and presentation	3/1249	77/7206	0.000679894604359
ko04710	Circadian rhythm	17/1249	43/7206	0.000736945089894
ko05140	Leishmaniasis	3/1249	75/7206	0.00101174372768
ko04626	Plant-pathogen interaction	9/1249	18/7206	0.00148928211181
ko05161	Hepatitis B	15/1249	173/7206	0.00151147927321
ko04915	Estrogen signaling pathway	37/1249	131/7206	0.00157130755905
ko04930	Type II diabetes mellitus	19/1249	54/7206	0.00160996691373
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1249	59/7206	0.00169728003794
ko05410	Hypertrophic cardiomyopathy (HCM)	30/1249	100/7206	0.00191460100458
ko04610	Complement and coagulation cascades	4/1249	79/7206	0.00236819270976
ko05166	HTLV-I infection	32/1249	292/7206	0.00262222051663
ko03420	Nucleotide excision repair	1/1249	46/7206	0.0027879222877
ko05205	Proteoglycans in cancer	30/1249	271/7206	0.00416500200941
ko03022	Basal transcription factors	1/1249	44/7206	0.00424764501502
ko04922	Glucagon signaling pathway	35/1249	128/7206	0.00437793065698
ko05144	Malaria	1/1249	45/7206	0.0044793762753
ko04330	Notch signaling pathway	3/1249	62/7206	0.00622891306353
ko04622	RIG-I-like receptor signaling pathway	3/1249	62/7206	0.00622891306353
ko04658	Th1 and Th2 cell differentiation	7/1249	96/7206	0.00630547409845
ko05133	Pertussis	6/1249	87/7206	0.00653167750486
ko05162	Measles	10/1249	120/7206	0.00704950869666
ko00240	Pyrimidine metabolism	9/1249	110/7206	0.00758066522612
ko04217	Necroptosis	18/1249	178/7206	0.00883974146072
ko03410	Base excision repair	1/1249	38/7206	0.00956186555322
ko00562	Inositol phosphate metabolism	25/1249	89/7206	0.0106207508584
ko04973	Carbohydrate digestion and absorption	14/1249	42/7206	0.0120639271137
ko05131	Shigellosis	6/1249	82/7206	0.012317278992
ko05321	Inflammatory bowel disease (IBD)	3/1249	56/7206	0.0126509314912
ko04270	Vascular smooth muscle contraction	39/1249	154/7206	0.0127811628596
ko05145	Toxoplasmosis	12/1249	126/7206	0.0172592458414
ko00280	Valine, leucine and isoleucine degradation	3/1249	54/7206	0.0180480412179
ko00480	Glutathione metabolism	3/1249	55/7206	0.0184198097466
ko04630	Jak-STAT signaling pathway	13/1249	132/7206	0.0199632252127
ko04657	IL-17 signaling pathway	7/1249	87/7206	0.0215161054751
ko04960	Aldosterone-regulated sodium reabsorption	13/1249	41/7206	0.0215583275189
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1249	14/7206	0.0228001558271
ko05217	Basal cell carcinoma	5/1249	68/7206	0.0243186550034
ko00590	Arachidonic acid metabolism	3/1249	52/7206	0.0257894112454
ko03018	RNA degradation	7/1249	84/7206	0.0286090630439
ko04213	Longevity regulating pathway - multiple species	23/1249	86/7206	0.0301625193531
ko04146	Peroxisome	8/1249	89/7206	0.0343500287293
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1249	40/7206	0.0356047317483
ko05214	Glioma	21/1249	79/7206	0.035731010026
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1249	182/7206	0.0369383107562
ko04912	GnRH signaling pathway	30/1249	122/7206	0.0396443707396
ko04214	Apoptosis - fly	6/1249	72/7206	0.0415985882068
ko04015	Rap1 signaling pathway	61/1249	278/7206	0.0431486117372
ko05016	Huntington's disease	26/1249	215/7206	0.043625815041
ko04640	Hematopoietic cell lineage	5/1249	64/7206	0.0453684110891
ko04210	Apoptosis	21/1249	180/7206	0.0455270645784
ko05320	Autoimmune thyroid disease	1/1249	29/7206	0.0479021157841
ko05340	Primary immunodeficiency	1/1249	30/7206	0.0491008458135
ko05231	Choline metabolism in cancer	32/1249	134/7206	0.0497357918694
ko04142	Lysosome	17/1249	151/7206	0.0498794180683