ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	197/1187	423/7206	5.78216629567e-51
ko04724	Glutamatergic synapse	91/1187	152/7206	2.090004142e-34
ko05033	Nicotine addiction	48/1187	56/7206	4.1464709737e-30
ko05032	Morphine addiction	71/1187	110/7206	5.37806452826e-30
ko04713	Circadian entrainment	77/1187	136/7206	5.51847004237e-27
ko04727	GABAergic synapse	66/1187	110/7206	2.87572287154e-25
ko04721	Synaptic vesicle cycle	51/1187	80/7206	1.74572673967e-21
ko04725	Cholinergic synapse	77/1187	160/7206	4.4115579355e-21
ko04728	Dopaminergic synapse	84/1187	185/7206	7.98969689377e-21
ko04024	cAMP signaling pathway	108/1187	279/7206	7.88631308456e-20
ko04723	Retrograde endocannabinoid signaling	79/1187	175/7206	1.8761463546e-19
ko04020	Calcium signaling pathway	102/1187	265/7206	1.4440410128e-18
ko04911	Insulin secretion	56/1187	117/7206	1.64190290611e-15
ko04742	Taste transduction	37/1187	61/7206	6.57599657428e-15
ko04921	Oxytocin signaling pathway	80/1187	209/7206	1.36912880433e-14
ko04726	Serotonergic synapse	59/1187	137/7206	1.06667099034e-13
ko04744	Phototransduction	25/1187	36/7206	1.9859126805e-12
ko05031	Amphetamine addiction	43/1187	91/7206	5.71041040114e-12
ko04720	Long-term potentiation	45/1187	99/7206	9.8667378884e-12
ko04261	Adrenergic signaling in cardiomyocytes	73/1187	205/7206	1.91621651178e-11
ko04970	Salivary secretion	43/1187	95/7206	3.40402152065e-11
ko03040	Spliceosome	1/1187	145/7206	1.93166179833e-10
ko04360	Axon guidance	72/1187	233/7206	2.61138244474e-08
ko04925	Aldosterone synthesis and secretion	41/1187	105/7206	2.61926454396e-08
ko04022	cGMP-PKG signaling pathway	67/1187	216/7206	6.86924533027e-08
ko05203	Viral carcinogenesis	16/1187	277/7206	8.2325333198e-08
ko04971	Gastric acid secretion	38/1187	98/7206	1.04588949788e-07
ko05030	Cocaine addiction	30/1187	73/7206	4.49604248295e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1187	74/7206	6.38762755043e-07
ko03013	RNA transport	7/1187	166/7206	1.2738347492e-06
ko04966	Collecting duct acid secretion	15/1187	26/7206	2.07785193892e-06
ko05322	Systemic lupus erythematosus	6/1187	151/7206	2.23593094443e-06
ko05168	Herpes simplex infection	9/1187	182/7206	2.34718294258e-06
ko04060	Cytokine-cytokine receptor interaction	10/1187	191/7206	2.54980149287e-06
ko04924	Renin secretion	32/1187	86/7206	2.75138032176e-06
ko04972	Pancreatic secretion	38/1187	111/7206	3.76852741062e-06
ko05164	Influenza A	8/1187	167/7206	4.31605216646e-06
ko04070	Phosphatidylinositol signaling system	38/1187	112/7206	4.60969783726e-06
ko04010	MAPK signaling pathway	84/1187	321/7206	6.71960733095e-06
ko04621	NOD-like receptor signaling pathway	8/1187	157/7206	1.74884175785e-05
ko04514	Cell adhesion molecules (CAMs)	41/1187	130/7206	2.01885816455e-05
ko04740	Olfactory transduction	29/1187	80/7206	2.23217980761e-05
ko04141	Protein processing in endoplasmic reticulum	11/1187	184/7206	2.87209436119e-05
ko04976	Bile secretion	28/1187	80/7206	4.88742534864e-05
ko05414	Dilated cardiomyopathy	35/1187	112/7206	8.98229974218e-05
ko04540	Gap junction	39/1187	128/7206	8.98889483415e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1187	79/7206	9.8289838143e-05
ko05110	Vibrio cholerae infection	23/1187	63/7206	0.000103466773857
ko04745	Phototransduction - fly	16/1187	38/7206	0.000158205382452
ko04923	Regulation of lipolysis in adipocytes	26/1187	77/7206	0.000162815103345
ko03008	Ribosome biogenesis in eukaryotes	2/1187	79/7206	0.000173642344358
ko04120	Ubiquitin mediated proteolysis	8/1187	138/7206	0.000271057437621
ko05169	Epstein-Barr virus infection	16/1187	206/7206	0.000272667466046
ko04730	Long-term depression	26/1187	78/7206	0.000288582450294
ko04072	Phospholipase D signaling pathway	52/1187	197/7206	0.000402636168214
ko04014	Ras signaling pathway	68/1187	279/7206	0.000518926409408
ko04371	Apelin signaling pathway	47/1187	177/7206	0.000630868844582
ko04915	Estrogen signaling pathway	37/1187	131/7206	0.000746269152288
ko04750	Inflammatory mediator regulation of TRP channels	35/1187	122/7206	0.000749823188479
ko04626	Plant-pathogen interaction	9/1187	18/7206	0.00101947109736
ko04612	Antigen processing and presentation	3/1187	77/7206	0.0010237510628
ko04610	Complement and coagulation cascades	3/1187	79/7206	0.00107834179696
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1187	59/7206	0.00109079325789
ko04710	Circadian rhythm	16/1187	43/7206	0.00125730666189
ko04964	Proximal tubule bicarbonate reclamation	12/1187	29/7206	0.00126039088403
ko04064	NF-kappa B signaling pathway	5/1187	96/7206	0.00127273292391
ko04260	Cardiac muscle contraction	29/1187	98/7206	0.00135144118174
ko05140	Leishmaniasis	3/1187	75/7206	0.0014891070804
ko05162	Measles	8/1187	120/7206	0.00182778708062
ko04110	Cell cycle	11/1187	145/7206	0.00214334370414
ko05205	Proteoglycans in cancer	27/1187	271/7206	0.00254783866192
ko00330	Arginine and proline metabolism	2/1187	61/7206	0.00266284393554
ko05161	Hepatitis B	15/1187	173/7206	0.00355052913016
ko04146	Peroxisome	5/1187	89/7206	0.00358624892901
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1187	14/7206	0.00380054457485
ko04630	Jak-STAT signaling pathway	10/1187	132/7206	0.00414984650145
ko05144	Malaria	1/1187	45/7206	0.00440285113736
ko00071	Fatty acid degradation	1/1187	45/7206	0.00440285113736
ko03420	Nucleotide excision repair	1/1187	46/7206	0.0044096137044
ko00480	Glutathione metabolism	2/1187	55/7206	0.00564840335692
ko04916	Melanogenesis	36/1187	142/7206	0.00589444267769
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1187	100/7206	0.00644038709647
ko03022	Basal transcription factors	1/1187	44/7206	0.00672506190932
ko00310	Lysine degradation	4/1187	73/7206	0.00680759883223
ko04918	Thyroid hormone synthesis	24/1187	86/7206	0.0076779713769
ko00590	Arachidonic acid metabolism	2/1187	52/7206	0.0082729860004
ko04622	RIG-I-like receptor signaling pathway	3/1187	62/7206	0.0091894414052
ko04922	Glucagon signaling pathway	32/1187	128/7206	0.0114349609712
ko00380	Tryptophan metabolism	2/1187	50/7206	0.0120369619208
ko04657	IL-17 signaling pathway	6/1187	87/7206	0.0127766761587
ko05133	Pertussis	6/1187	87/7206	0.0127766761587
ko04912	GnRH signaling pathway	31/1187	122/7206	0.0130797331757
ko00562	Inositol phosphate metabolism	24/1187	89/7206	0.0134357021177
ko03410	Base excision repair	1/1187	38/7206	0.0147925505425
ko04270	Vascular smooth muscle contraction	37/1187	154/7206	0.0151559902462
ko05145	Toxoplasmosis	11/1187	126/7206	0.0151805749269
ko03018	RNA degradation	6/1187	84/7206	0.017355765472
ko00260	Glycine, serine and threonine metabolism	2/1187	48/7206	0.0176170337864
ko05219	Bladder cancer	2/1187	48/7206	0.0176170337864
ko04217	Necroptosis	18/1187	178/7206	0.0184418408017
ko05321	Inflammatory bowel disease (IBD)	3/1187	56/7206	0.0186383296446
ko04210	Apoptosis	18/1187	180/7206	0.0186953955252
ko05131	Shigellosis	6/1187	82/7206	0.0236652459584
ko04214	Apoptosis - fly	5/1187	72/7206	0.024974596302
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1187	182/7206	0.0256105136006
ko04115	p53 signaling pathway	5/1187	74/7206	0.0257638402663
ko04640	Hematopoietic cell lineage	4/1187	64/7206	0.0262869453519
ko00280	Valine, leucine and isoleucine degradation	3/1187	54/7206	0.0263300749137
ko04658	Th1 and Th2 cell differentiation	8/1187	96/7206	0.0267147514546
ko04114	Oocyte meiosis	33/1187	139/7206	0.0273911554931
ko04015	Rap1 signaling pathway	59/1187	278/7206	0.0320870641629
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1187	92/7206	0.0331228233616
ko00860	Porphyrin and chlorophyll metabolism	1/1187	34/7206	0.0336874046101
ko03320	PPAR signaling pathway	5/1187	69/7206	0.0341153425022
ko00240	Pyrimidine metabolism	10/1187	110/7206	0.0373016343104
ko05215	Prostate cancer	10/1187	111/7206	0.037839957064
ko04930	Type II diabetes mellitus	15/1187	54/7206	0.0399525873578
ko04620	Toll-like receptor signaling pathway	9/1187	100/7206	0.0414846492979
ko04510	Focal adhesion	28/1187	240/7206	0.0416016040342
ko04062	Chemokine signaling pathway	44/1187	201/7206	0.0423399347575
ko01524	Platinum drug resistance	6/1187	76/7206	0.0426319026154
ko04711	Circadian rhythm - fly	5/1187	13/7206	0.0487848136013
ko05340	Primary immunodeficiency	1/1187	30/7206	0.0490258844333