ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	176/978	423/7206	1.48132953717e-49
ko05033	Nicotine addiction	42/978	56/7206	1.47428608211e-25
ko04724	Glutamatergic synapse	72/978	152/7206	2.21971756428e-24
ko05032	Morphine addiction	55/978	110/7206	2.88908595854e-20
ko04713	Circadian entrainment	61/978	136/7206	2.64177918464e-19
ko04727	GABAergic synapse	51/978	110/7206	4.40068621746e-17
ko04728	Dopaminergic synapse	70/978	185/7206	4.62846695088e-17
ko04020	Calcium signaling pathway	88/978	265/7206	6.5637685313e-17
ko04723	Retrograde endocannabinoid signaling	64/978	175/7206	7.36891959408e-15
ko04725	Cholinergic synapse	60/978	160/7206	1.41713844693e-14
ko04721	Synaptic vesicle cycle	39/978	80/7206	2.94976262997e-14
ko04921	Oxytocin signaling pathway	67/978	209/7206	3.6255658669e-12
ko04726	Serotonergic synapse	50/978	137/7206	7.79405729581e-12
ko04911	Insulin secretion	45/978	117/7206	1.10677239437e-11
ko04024	cAMP signaling pathway	79/978	279/7206	4.37379795833e-11
ko04742	Taste transduction	29/978	61/7206	1.34511066585e-10
ko05031	Amphetamine addiction	35/978	91/7206	2.23273998129e-09
ko04970	Salivary secretion	35/978	95/7206	8.43669595083e-09
ko04261	Adrenergic signaling in cardiomyocytes	57/978	205/7206	6.39927779977e-08
ko04925	Aldosterone synthesis and secretion	35/978	105/7206	1.56453933399e-07
ko03010	Ribosome	1/978	129/7206	1.84128220748e-07
ko03040	Spliceosome	2/978	145/7206	2.46986451896e-07
ko04120	Ubiquitin mediated proteolysis	2/978	138/7206	8.80715954462e-07
ko05322	Systemic lupus erythematosus	3/978	151/7206	9.05312778141e-07
ko04720	Long-term potentiation	32/978	99/7206	1.63789091032e-06
ko04022	cGMP-PKG signaling pathway	55/978	216/7206	2.34349649555e-06
ko03013	RNA transport	5/978	166/7206	5.26811187336e-06
ko05164	Influenza A	5/978	167/7206	5.38618069077e-06
ko04730	Long-term depression	26/978	78/7206	6.14988165918e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	25/978	74/7206	7.06348934516e-06
ko04971	Gastric acid secretion	30/978	98/7206	9.17439265425e-06
ko05030	Cocaine addiction	24/978	73/7206	1.81254562256e-05
ko04972	Pancreatic secretion	32/978	111/7206	1.88990603992e-05
ko04514	Cell adhesion molecules (CAMs)	36/978	130/7206	2.24504923963e-05
ko04010	MAPK signaling pathway	70/978	321/7206	3.78926573069e-05
ko05168	Herpes simplex infection	8/978	182/7206	6.352672214e-05
ko04110	Cell cycle	5/978	145/7206	6.70977369262e-05
ko05203	Viral carcinogenesis	17/978	277/7206	7.49911172511e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/978	79/7206	8.65608166264e-05
ko04060	Cytokine-cytokine receptor interaction	9/978	191/7206	9.37290814169e-05
ko04072	Phospholipase D signaling pathway	46/978	197/7206	0.000186102057731
ko04360	Axon guidance	52/978	233/7206	0.000197530395763
ko03008	Ribosome biogenesis in eukaryotes	1/978	79/7206	0.000202811305123
ko05162	Measles	4/978	120/7206	0.000237008101249
ko05110	Vibrio cholerae infection	20/978	63/7206	0.000252362011054
ko04710	Circadian rhythm	15/978	43/7206	0.000323957906704
ko04014	Ras signaling pathway	59/978	279/7206	0.000343143792079
ko04924	Renin secretion	24/978	86/7206	0.000377315128147
ko04070	Phosphatidylinositol signaling system	29/978	112/7206	0.000416808770783
ko04270	Vascular smooth muscle contraction	37/978	154/7206	0.000468545157488
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/978	59/7206	0.000737834280382
ko05410	Hypertrophic cardiomyopathy (HCM)	26/978	100/7206	0.000962721298671
ko04540	Gap junction	31/978	128/7206	0.000987314881482
ko05414	Dilated cardiomyopathy	28/978	112/7206	0.00114282712613
ko04750	Inflammatory mediator regulation of TRP channels	30/978	122/7206	0.00115077315907
ko04630	Jak-STAT signaling pathway	6/978	132/7206	0.00115530174982
ko05169	Epstein-Barr virus infection	13/978	206/7206	0.00125642144131
ko04966	Collecting duct acid secretion	10/978	26/7206	0.0013687052243
ko04141	Protein processing in endoplasmic reticulum	11/978	184/7206	0.00142025242873
ko04976	Bile secretion	21/978	80/7206	0.00253509445313
ko05161	Hepatitis B	11/978	173/7206	0.00330277396612
ko04745	Phototransduction - fly	12/978	38/7206	0.00332343541882
ko04260	Cardiac muscle contraction	24/978	98/7206	0.00414936644792
ko04740	Olfactory transduction	20/978	80/7206	0.00495040727103
ko05166	HTLV-I infection	24/978	292/7206	0.00510961264339
ko04218	Cellular senescence	12/978	177/7206	0.00530296220034
ko05205	Proteoglycans in cancer	22/978	271/7206	0.00646106738576
ko04146	Peroxisome	4/978	89/7206	0.00770566715054
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/978	182/7206	0.0082308914778
ko05140	Leishmaniasis	3/978	75/7206	0.0103438611324
ko05133	Pertussis	4/978	87/7206	0.0108441516163
ko04621	NOD-like receptor signaling pathway	11/978	157/7206	0.0129289784336
ko00330	Arginine and proline metabolism	2/978	61/7206	0.0135165503284
ko04930	Type II diabetes mellitus	14/978	54/7206	0.0145761111215
ko00310	Lysine degradation	3/978	73/7206	0.0148302735402
ko05212	Pancreatic cancer	4/978	83/7206	0.0149402003728
ko04550	Signaling pathways regulating pluripotency of stem cells	12/978	165/7206	0.0152340486737
ko03420	Nucleotide excision repair	1/978	46/7206	0.0164659611035
ko05219	Bladder cancer	1/978	48/7206	0.0173060994593
ko04371	Apelin signaling pathway	35/978	177/7206	0.0191849891588
ko04960	Aldosterone-regulated sodium reabsorption	11/978	41/7206	0.0203700280474
ko05215	Prostate cancer	7/978	111/7206	0.0242961879101
ko04015	Rap1 signaling pathway	51/978	278/7206	0.0250651338174
ko05016	Huntington's disease	18/978	215/7206	0.0254917152128
ko00071	Fatty acid degradation	1/978	45/7206	0.0255807824743
ko04217	Necroptosis	14/978	178/7206	0.0258858488084
ko04620	Toll-like receptor signaling pathway	6/978	100/7206	0.0261209722016
ko04071	Sphingolipid signaling pathway	32/978	162/7206	0.0267366289038
ko04614	Renin-angiotensin system	6/978	18/7206	0.0268231741652
ko04915	Estrogen signaling pathway	27/978	131/7206	0.0274273561325
ko00280	Valine, leucine and isoleucine degradation	2/978	54/7206	0.0277661963361
ko00520	Amino sugar and nucleotide sugar metabolism	2/978	55/7206	0.0279444716209
ko05321	Inflammatory bowel disease (IBD)	2/978	56/7206	0.0285725954339
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/978	14/7206	0.0317176951519
ko05145	Toxoplasmosis	9/978	126/7206	0.0347407912937
ko02010	ABC transporters	10/978	39/7206	0.0350138503022
ko04922	Glucagon signaling pathway	26/978	128/7206	0.0358596272096
ko05220	Chronic myeloid leukemia	5/978	85/7206	0.0371652215569
ko04622	RIG-I-like receptor signaling pathway	3/978	62/7206	0.0402417890354
ko00680	Methane metabolism	9/978	34/7206	0.0403921187635
ko04964	Proximal tubule bicarbonate reclamation	8/978	29/7206	0.0492750760982