ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 76/552 145/7206 2.33376003452e-47 ko03050 Proteasome 37/552 54/7206 2.28619032749e-29 ko03013 RNA transport 50/552 166/7206 4.17603775041e-18 ko04080 Neuroactive ligand-receptor interaction 1/552 423/7206 4.95117663468e-14 ko03030 DNA replication 20/552 38/7206 3.16079355442e-13 ko05169 Epstein-Barr virus infection 45/552 206/7206 6.05592962522e-11 ko03015 mRNA surveillance pathway 28/552 93/7206 1.19240669395e-10 ko03008 Ribosome biogenesis in eukaryotes 25/552 79/7206 3.67866106164e-10 ko04110 Cell cycle 34/552 145/7206 2.07808541335e-09 ko03420 Nucleotide excision repair 16/552 46/7206 1.28978205237e-07 ko03020 RNA polymerase 12/552 29/7206 5.61176239911e-07 ko03430 Mismatch repair 10/552 22/7206 1.78500412905e-06 ko00240 Pyrimidine metabolism 24/552 110/7206 2.04177041375e-06 ko03060 Protein export 10/552 23/7206 2.9432022162e-06 ko03018 RNA degradation 20/552 84/7206 3.533423354e-06 ko03022 Basal transcription factors 13/552 44/7206 1.53737472749e-05 ko03410 Base excision repair 12/552 38/7206 1.5419791381e-05 ko04723 Retrograde endocannabinoid signaling 1/552 175/7206 1.93208198396e-05 ko05010 Alzheimer's disease 2/552 202/7206 2.22535887714e-05 ko04024 cAMP signaling pathway 5/552 279/7206 2.57609105485e-05 ko04141 Protein processing in endoplasmic reticulum 31/552 184/7206 2.75637271157e-05 ko04111 Cell cycle - yeast 19/552 90/7206 3.86437566734e-05 ko04725 Cholinergic synapse 1/552 160/7206 6.30633539114e-05 ko04120 Ubiquitin mediated proteolysis 24/552 138/7206 0.00012494539761 ko04724 Glutamatergic synapse 1/552 152/7206 0.000143274342441 ko04068 FoxO signaling pathway 2/552 167/7206 0.000313434145288 ko04022 cGMP-PKG signaling pathway 4/552 216/7206 0.00035777561083 ko00970 Aminoacyl-tRNA biosynthesis 11/552 44/7206 0.000359211149369 ko04380 Osteoclast differentiation 1/552 134/7206 0.000442644025702 ko04713 Circadian entrainment 1/552 136/7206 0.000454751603081 ko05012 Parkinson's disease 2/552 155/7206 0.00064878632267 ko04261 Adrenergic signaling in cardiomyocytes 4/552 205/7206 0.000706447920112 ko04113 Meiosis - yeast 14/552 70/7206 0.000711333686325 ko04010 MAPK signaling pathway 10/552 321/7206 0.000794536557702 ko00230 Purine metabolism 28/552 194/7206 0.000917423425447 ko04060 Cytokine-cytokine receptor interaction 4/552 191/7206 0.00133435321758 ko04550 Signaling pathways regulating pluripotency of stem cells 3/552 165/7206 0.00165172148326 ko04070 Phosphatidylinositol signaling system 1/552 112/7206 0.00206201506852 ko04727 GABAergic synapse 1/552 110/7206 0.003103897406 ko05032 Morphine addiction 1/552 110/7206 0.003103897406 ko03440 Homologous recombination 9/552 41/7206 0.00323717703522 ko04371 Apelin signaling pathway 4/552 177/7206 0.00370217009781 ko05142 Chagas disease (American trypanosomiasis) 2/552 130/7206 0.00403501381817 ko04514 Cell adhesion molecules (CAMs) 2/552 130/7206 0.00403501381817 ko04915 Estrogen signaling pathway 2/552 131/7206 0.00409487698284 ko04630 Jak-STAT signaling pathway 2/552 132/7206 0.00417900953207 ko05168 Herpes simplex infection 25/552 182/7206 0.0041909323925 ko04659 Th17 cell differentiation 1/552 106/7206 0.00467347432356 ko04142 Lysosome 3/552 151/7206 0.00472209783844 ko04912 GnRH signaling pathway 2/552 122/7206 0.00570338550901 ko05145 Toxoplasmosis 2/552 126/7206 0.00588396226391 ko04650 Natural killer cell mediated cytotoxicity 1/552 97/7206 0.00645200301923 ko05146 Amoebiasis 1/552 99/7206 0.00656653954009 ko04620 Toll-like receptor signaling pathway 1/552 100/7206 0.0066922626226 ko04611 Platelet activation 4/552 163/7206 0.00692748100533 ko04728 Dopaminergic synapse 5/552 185/7206 0.00715626887619 ko04668 TNF signaling pathway 2/552 120/7206 0.00829189380487 ko04726 Serotonergic synapse 3/552 137/7206 0.0090980075963 ko05031 Amphetamine addiction 1/552 91/7206 0.00941443952914 ko05120 Epithelial cell signaling in Helicobacter pylori infection 1/552 92/7206 0.00941726637059 ko04621 NOD-like receptor signaling pathway 4/552 157/7206 0.00954845491745 ko05205 Proteoglycans in cancer 10/552 271/7206 0.00994454424743 ko04658 Th1 and Th2 cell differentiation 1/552 96/7206 0.0100692741073 ko04712 Circadian rhythm - plant 3/552 7/7206 0.0123877276104 ko00510 N-Glycan biosynthesis 9/552 50/7206 0.0125228931759 ko05231 Choline metabolism in cancer 3/552 134/7206 0.0128152020524 ko04918 Thyroid hormone synthesis 1/552 86/7206 0.0137000287932 ko04917 Prolactin signaling pathway 1/552 87/7206 0.0137293272182 ko05200 Pathways in cancer 24/552 492/7206 0.0138340435386 ko05323 Rheumatoid arthritis 1/552 89/7206 0.0140564671208 ko00562 Inositol phosphate metabolism 1/552 89/7206 0.0140564671208 ko04015 Rap1 signaling pathway 11/552 278/7206 0.0152649090981 ko04014 Ras signaling pathway 11/552 279/7206 0.0153238687851 ko04921 Oxytocin signaling pathway 7/552 209/7206 0.0164830352358 ko04151 PI3K-Akt signaling pathway 18/552 390/7206 0.0184335766367 ko05230 Central carbon metabolism in cancer 1/552 81/7206 0.0199118501736 ko04062 Chemokine signaling pathway 7/552 201/7206 0.0213644264533 ko04932 Non-alcoholic fatty liver disease (NAFLD) 6/552 182/7206 0.0228317082501 ko04360 Axon guidance 9/552 233/7206 0.0236829782298 ko04750 Inflammatory mediator regulation of TRP channels 3/552 122/7206 0.0245062533336 ko04370 VEGF signaling pathway 1/552 77/7206 0.0290660950822 ko04664 Fc epsilon RI signaling pathway 1/552 77/7206 0.0290660950822 ko04976 Bile secretion 1/552 80/7206 0.0305984489714 ko04270 Vascular smooth muscle contraction 5/552 154/7206 0.0319287103518 ko04933 AGE-RAGE signaling pathway in diabetic complications 4/552 135/7206 0.033276758911 ko04931 Insulin resistance 4/552 137/7206 0.0334986467895 ko00564 Glycerophospholipid metabolism 2/552 99/7206 0.0335177139212 ko04510 Focal adhesion 10/552 240/7206 0.0356002523892 ko05034 Alcoholism 10/552 238/7206 0.0460257480699 ko04972 Pancreatic secretion 3/552 111/7206 0.0465085550459 ko05130 Pathogenic Escherichia coli infection 11/552 77/7206 0.0472708393126