ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	203/1216	423/7206	1.95046429641e-53
ko04724	Glutamatergic synapse	91/1216	152/7206	1.53114001448e-33
ko05033	Nicotine addiction	48/1216	56/7206	1.30194836311e-29
ko05032	Morphine addiction	71/1216	110/7206	2.6116611971e-29
ko04713	Circadian entrainment	78/1216	136/7206	4.10560036669e-27
ko04727	GABAergic synapse	67/1216	110/7206	1.51595939363e-25
ko04725	Cholinergic synapse	78/1216	160/7206	4.1278527867e-21
ko04728	Dopaminergic synapse	85/1216	185/7206	9.14101555942e-21
ko04721	Synaptic vesicle cycle	49/1216	80/7206	3.88594448185e-19
ko04723	Retrograde endocannabinoid signaling	79/1216	175/7206	8.51980863014e-19
ko04020	Calcium signaling pathway	104/1216	265/7206	1.06152251186e-18
ko04024	cAMP signaling pathway	107/1216	279/7206	2.16526196201e-18
ko04726	Serotonergic synapse	62/1216	137/7206	4.633715258e-15
ko04911	Insulin secretion	56/1216	117/7206	4.90903151283e-15
ko04742	Taste transduction	36/1216	61/7206	1.10023493335e-13
ko04921	Oxytocin signaling pathway	79/1216	209/7206	1.69471614082e-13
ko05031	Amphetamine addiction	43/1216	91/7206	1.31166386824e-11
ko04261	Adrenergic signaling in cardiomyocytes	74/1216	205/7206	1.64704937252e-11
ko04970	Salivary secretion	44/1216	95/7206	1.76943673647e-11
ko04744	Phototransduction	24/1216	36/7206	3.67433838622e-11
ko03040	Spliceosome	1/1216	145/7206	1.23203561012e-10
ko04720	Long-term potentiation	42/1216	99/7206	1.51327067444e-09
ko03010	Ribosome	1/1216	129/7206	1.53227100929e-09
ko04925	Aldosterone synthesis and secretion	42/1216	105/7206	1.57820268567e-08
ko04971	Gastric acid secretion	38/1216	98/7206	1.7597776053e-07
ko05030	Cocaine addiction	31/1216	73/7206	2.08222870564e-07
ko04022	cGMP-PKG signaling pathway	67/1216	216/7206	2.45332693851e-07
ko05322	Systemic lupus erythematosus	5/1216	151/7206	2.49487739485e-07
ko04360	Axon guidance	70/1216	233/7206	4.36922539974e-07
ko03013	RNA transport	7/1216	166/7206	8.63580456433e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1216	74/7206	1.08587952774e-06
ko04070	Phosphatidylinositol signaling system	40/1216	112/7206	1.24379134874e-06
ko05168	Herpes simplex infection	9/1216	182/7206	1.63189263158e-06
ko04060	Cytokine-cytokine receptor interaction	11/1216	191/7206	5.08404391187e-06
ko05203	Viral carcinogenesis	21/1216	277/7206	5.80858386509e-06
ko04972	Pancreatic secretion	38/1216	111/7206	8.27184023811e-06
ko05164	Influenza A	9/1216	167/7206	1.33218292687e-05
ko04141	Protein processing in endoplasmic reticulum	11/1216	184/7206	1.39834211209e-05
ko04514	Cell adhesion molecules (CAMs)	42/1216	130/7206	1.41922730631e-05
ko04014	Ras signaling pathway	75/1216	279/7206	1.90253285716e-05
ko04740	Olfactory transduction	29/1216	80/7206	2.79764077326e-05
ko04010	MAPK signaling pathway	83/1216	321/7206	3.38023155524e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1216	122/7206	4.06146251314e-05
ko04072	Phospholipase D signaling pathway	56/1216	197/7206	4.1990394029e-05
ko04924	Renin secretion	30/1216	86/7206	5.68697562494e-05
ko04923	Regulation of lipolysis in adipocytes	27/1216	77/7206	9.17096073504e-05
ko04966	Collecting duct acid secretion	13/1216	26/7206	0.000100143534667
ko03008	Ribosome biogenesis in eukaryotes	2/1216	79/7206	0.00011009263244
ko04540	Gap junction	39/1216	128/7206	0.000115034052489
ko04621	NOD-like receptor signaling pathway	10/1216	157/7206	0.000136367182319
ko05414	Dilated cardiomyopathy	35/1216	112/7206	0.000173457139911
ko04730	Long-term depression	27/1216	78/7206	0.000177417765969
ko04745	Phototransduction - fly	16/1216	38/7206	0.000211752089158
ko04976	Bile secretion	27/1216	80/7206	0.000222972694948
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1216	79/7206	0.000413819154759
ko04120	Ubiquitin mediated proteolysis	9/1216	138/7206	0.000497494043496
ko04371	Apelin signaling pathway	48/1216	177/7206	0.000501367619865
ko04110	Cell cycle	10/1216	145/7206	0.000677984024736
ko04915	Estrogen signaling pathway	37/1216	131/7206	0.000915421454106
ko05140	Leishmaniasis	3/1216	75/7206	0.000998908735389
ko04612	Antigen processing and presentation	3/1216	77/7206	0.00104243069869
ko05110	Vibrio cholerae infection	21/1216	63/7206	0.00116876421867
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1216	59/7206	0.00131456382196
ko04930	Type II diabetes mellitus	19/1216	54/7206	0.0013950703623
ko04964	Proximal tubule bicarbonate reclamation	12/1216	29/7206	0.00156746469377
ko04146	Peroxisome	5/1216	89/7206	0.00247936803086
ko04710	Circadian rhythm	15/1216	43/7206	0.00357877625078
ko00562	Inositol phosphate metabolism	26/1216	89/7206	0.0038731886976
ko04260	Cardiac muscle contraction	28/1216	98/7206	0.00388306886652
ko03022	Basal transcription factors	1/1216	44/7206	0.00431102329269
ko05144	Malaria	1/1216	45/7206	0.00432810474661
ko00071	Fatty acid degradation	1/1216	45/7206	0.00432810474661
ko05162	Measles	9/1216	120/7206	0.00433693374721
ko03420	Nucleotide excision repair	1/1216	46/7206	0.00452382656709
ko04217	Necroptosis	17/1216	178/7206	0.0061499559789
ko04270	Vascular smooth muscle contraction	39/1216	154/7206	0.00643978692159
ko05169	Epstein-Barr virus infection	21/1216	206/7206	0.00801898172635
ko05205	Proteoglycans in cancer	30/1216	271/7206	0.00802901049619
ko04064	NF-kappa B signaling pathway	7/1216	96/7206	0.008764789019
ko04657	IL-17 signaling pathway	6/1216	87/7206	0.00916223118418
ko05133	Pertussis	6/1216	87/7206	0.00916223118418
ko04622	RIG-I-like receptor signaling pathway	3/1216	62/7206	0.00939459994149
ko04610	Complement and coagulation cascades	5/1216	79/7206	0.00948066212479
ko05161	Hepatitis B	17/1216	173/7206	0.0100607672135
ko04973	Carbohydrate digestion and absorption	14/1216	42/7206	0.0109212360029
ko03018	RNA degradation	6/1216	84/7206	0.0125550057443
ko04912	GnRH signaling pathway	31/1216	122/7206	0.0145061333648
ko03410	Base excision repair	1/1216	38/7206	0.0148283312754
ko04922	Glucagon signaling pathway	32/1216	128/7206	0.0169624142276
ko05131	Shigellosis	6/1216	82/7206	0.0171037157473
ko04015	Rap1 signaling pathway	62/1216	278/7206	0.0175764852938
ko00310	Lysine degradation	5/1216	73/7206	0.01795314922
ko05219	Bladder cancer	2/1216	48/7206	0.0180846764596
ko00480	Glutathione metabolism	3/1216	55/7206	0.0183316067427
ko04960	Aldosterone-regulated sodium reabsorption	13/1216	41/7206	0.0189923399488
ko05231	Choline metabolism in cancer	33/1216	134/7206	0.0195783140337
ko04213	Longevity regulating pathway - multiple species	23/1216	86/7206	0.0196264054838
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1216	14/7206	0.0201142364351
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1216	100/7206	0.0212230896363
ko04626	Plant-pathogen interaction	7/1216	18/7206	0.0218623304691
ko00500	Starch and sucrose metabolism	1/1216	35/7206	0.0218777994111
ko04214	Apoptosis - fly	5/1216	72/7206	0.0252448316792
ko00330	Arginine and proline metabolism	4/1216	61/7206	0.0257320067559
ko00280	Valine, leucine and isoleucine degradation	3/1216	54/7206	0.0265776702979
ko04658	Th1 and Th2 cell differentiation	8/1216	96/7206	0.0269289585844
ko00240	Pyrimidine metabolism	10/1216	110/7206	0.0283825469731
ko05145	Toxoplasmosis	12/1216	126/7206	0.0297870646202
ko03320	PPAR signaling pathway	5/1216	69/7206	0.0341344255294
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1216	182/7206	0.0346417737388
ko03015	mRNA surveillance pathway	8/1216	93/7206	0.0352946304389
ko00590	Arachidonic acid metabolism	3/1216	52/7206	0.0382046383399
ko04918	Thyroid hormone synthesis	22/1216	86/7206	0.0410655837902
ko04722	Neurotrophin signaling pathway	37/1216	160/7206	0.0417452152663
ko04115	p53 signaling pathway	6/1216	74/7206	0.042137238089
ko04510	Focal adhesion	29/1216	240/7206	0.0437249296068
ko04071	Sphingolipid signaling pathway	37/1216	162/7206	0.0439231420892
ko05340	Primary immunodeficiency	1/1216	30/7206	0.0486263225148
ko05321	Inflammatory bowel disease (IBD)	4/1216	56/7206	0.0491165002778
ko05214	Glioma	20/1216	79/7206	0.0495745819157