ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	196/1158	423/7206	4.41564696652e-52
ko04724	Glutamatergic synapse	89/1158	152/7206	1.78181924102e-33
ko04713	Circadian entrainment	76/1158	136/7206	7.27480363105e-27
ko05032	Morphine addiction	67/1158	110/7206	7.84426516231e-27
ko05033	Nicotine addiction	45/1158	56/7206	2.18312028911e-26
ko04727	GABAergic synapse	63/1158	110/7206	3.12940878917e-23
ko04725	Cholinergic synapse	76/1158	160/7206	4.64386380971e-21
ko04728	Dopaminergic synapse	83/1158	185/7206	6.86677194872e-21
ko04020	Calcium signaling pathway	105/1158	265/7206	7.32975414398e-21
ko04721	Synaptic vesicle cycle	48/1158	80/7206	3.77188933937e-19
ko04024	cAMP signaling pathway	105/1158	279/7206	4.51551641598e-19
ko04911	Insulin secretion	58/1158	117/7206	1.95170558842e-17
ko04723	Retrograde endocannabinoid signaling	74/1158	175/7206	5.81207793748e-17
ko04921	Oxytocin signaling pathway	81/1158	209/7206	9.3251112825e-16
ko04726	Serotonergic synapse	61/1158	137/7206	1.88108567257e-15
ko04742	Taste transduction	37/1158	61/7206	2.90210126785e-15
ko04970	Salivary secretion	46/1158	95/7206	1.32598311721e-13
ko05031	Amphetamine addiction	42/1158	91/7206	1.1540222053e-11
ko04744	Phototransduction	24/1158	36/7206	1.25447071611e-11
ko04720	Long-term potentiation	44/1158	99/7206	1.8184361746e-11
ko04261	Adrenergic signaling in cardiomyocytes	71/1158	205/7206	4.84910829307e-11
ko04925	Aldosterone synthesis and secretion	42/1158	105/7206	2.80450923378e-09
ko04971	Gastric acid secretion	40/1158	98/7206	3.3344222713e-09
ko03040	Spliceosome	2/1158	145/7206	6.65890964283e-09
ko04022	cGMP-PKG signaling pathway	68/1158	216/7206	1.41037526915e-08
ko04740	Olfactory transduction	34/1158	80/7206	1.49064607098e-08
ko05203	Viral carcinogenesis	15/1158	277/7206	6.00332758617e-08
ko05322	Systemic lupus erythematosus	4/1158	151/7206	1.35729088518e-07
ko04360	Axon guidance	69/1158	233/7206	1.4637094654e-07
ko04010	MAPK signaling pathway	86/1158	321/7206	5.16102593258e-07
ko04924	Renin secretion	33/1158	86/7206	7.06081235259e-07
ko05168	Herpes simplex infection	8/1158	182/7206	1.08238940679e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1158	74/7206	1.33343366125e-06
ko04730	Long-term depression	30/1158	78/7206	1.40163653067e-06
ko03013	RNA transport	7/1158	166/7206	2.82453111902e-06
ko05030	Cocaine addiction	28/1158	73/7206	3.34208931516e-06
ko04060	Cytokine-cytokine receptor interaction	10/1158	191/7206	5.28903236714e-06
ko04972	Pancreatic secretion	37/1158	111/7206	5.73296468286e-06
ko04120	Ubiquitin mediated proteolysis	5/1158	138/7206	5.83867396814e-06
ko04966	Collecting duct acid secretion	14/1158	26/7206	1.01453067169e-05
ko04014	Ras signaling pathway	73/1158	279/7206	1.26745434837e-05
ko04540	Gap junction	40/1158	128/7206	1.49866375918e-05
ko04070	Phosphatidylinositol signaling system	36/1158	112/7206	2.16140586603e-05
ko04745	Phototransduction - fly	17/1158	38/7206	2.78573482819e-05
ko04514	Cell adhesion molecules (CAMs)	40/1158	130/7206	2.88501763223e-05
ko04621	NOD-like receptor signaling pathway	8/1158	157/7206	3.68182559882e-05
ko05164	Influenza A	9/1158	167/7206	3.94467015933e-05
ko04964	Proximal tubule bicarbonate reclamation	14/1158	29/7206	5.056483079e-05
ko04976	Bile secretion	27/1158	80/7206	8.51327560664e-05
ko04110	Cell cycle	8/1158	145/7206	0.000139933484361
ko04141	Protein processing in endoplasmic reticulum	12/1158	184/7206	0.000142558306582
ko04750	Inflammatory mediator regulation of TRP channels	36/1158	122/7206	0.000157115031899
ko04371	Apelin signaling pathway	48/1158	177/7206	0.000161462450927
ko05110	Vibrio cholerae infection	22/1158	63/7206	0.000205311084436
ko03008	Ribosome biogenesis in eukaryotes	2/1158	79/7206	0.000276229871539
ko04072	Phospholipase D signaling pathway	51/1158	197/7206	0.000354495313165
ko05169	Epstein-Barr virus infection	16/1158	206/7206	0.000493304051926
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1158	79/7206	0.000533013879353
ko04710	Circadian rhythm	16/1158	43/7206	0.000629268760237
ko04260	Cardiac muscle contraction	29/1158	98/7206	0.000725553583144
ko04923	Regulation of lipolysis in adipocytes	24/1158	77/7206	0.00084784019743
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1158	59/7206	0.00095750539165
ko05162	Measles	7/1158	120/7206	0.00099444120166
ko00480	Glutathione metabolism	1/1158	55/7206	0.00132869615798
ko04915	Estrogen signaling pathway	35/1158	131/7206	0.001640540974
ko05414	Dilated cardiomyopathy	31/1158	112/7206	0.00164786938351
ko04064	NF-kappa B signaling pathway	5/1158	96/7206	0.0018429626868
ko05140	Leishmaniasis	3/1158	75/7206	0.00224369392346
ko04330	Notch signaling pathway	2/1158	62/7206	0.00269224621024
ko00330	Arginine and proline metabolism	2/1158	61/7206	0.00269407721353
ko04015	Rap1 signaling pathway	63/1158	278/7206	0.00343791591226
ko04626	Plant-pathogen interaction	8/1158	18/7206	0.00418714123367
ko04930	Type II diabetes mellitus	17/1158	54/7206	0.00441438400804
ko04610	Complement and coagulation cascades	4/1158	79/7206	0.00496296782316
ko04657	IL-17 signaling pathway	5/1158	87/7206	0.00504810008227
ko04146	Peroxisome	5/1158	89/7206	0.00517441372994
ko04270	Vascular smooth muscle contraction	38/1158	154/7206	0.005277260438
ko05166	HTLV-I infection	30/1158	292/7206	0.00549520042218
ko05161	Hepatitis B	15/1158	173/7206	0.00613999810936
ko03022	Basal transcription factors	1/1158	44/7206	0.00671043251049
ko00071	Fatty acid degradation	1/1158	45/7206	0.00682998024166
ko05205	Proteoglycans in cancer	28/1158	271/7206	0.00694771364131
ko04612	Antigen processing and presentation	4/1158	77/7206	0.00713029654338
ko03420	Nucleotide excision repair	1/1158	46/7206	0.00719329106706
ko00562	Inositol phosphate metabolism	24/1158	89/7206	0.00826834592531
ko00280	Valine, leucine and isoleucine degradation	2/1158	54/7206	0.00841359159656
ko04115	p53 signaling pathway	4/1158	74/7206	0.00991049887051
ko04922	Glucagon signaling pathway	32/1158	128/7206	0.0101285160791
ko05016	Huntington's disease	21/1158	215/7206	0.0105463503919
ko04630	Jak-STAT signaling pathway	11/1158	132/7206	0.0117843926137
ko04912	GnRH signaling pathway	30/1158	122/7206	0.0127579776494
ko04622	RIG-I-like receptor signaling pathway	3/1158	62/7206	0.0136152769813
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1158	14/7206	0.0159576231975
ko04960	Aldosterone-regulated sodium reabsorption	13/1158	41/7206	0.016198453405
ko04217	Necroptosis	17/1158	178/7206	0.0169120731312
ko05231	Choline metabolism in cancer	32/1158	134/7206	0.017132198688
ko04973	Carbohydrate digestion and absorption	13/1158	42/7206	0.0175556186866
ko05133	Pertussis	6/1158	87/7206	0.0177749984249
ko00380	Tryptophan metabolism	2/1158	50/7206	0.0183096689446
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1158	182/7206	0.0187014800318
ko05217	Basal cell carcinoma	4/1158	68/7206	0.0190889446847
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1158	100/7206	0.0191969075967
ko05214	Glioma	21/1158	79/7206	0.019378020226
ko05145	Toxoplasmosis	11/1158	126/7206	0.0200680760197
ko03018	RNA degradation	6/1158	84/7206	0.023966591139
ko00240	Pyrimidine metabolism	9/1158	110/7206	0.0250508470826
ko04640	Hematopoietic cell lineage	4/1158	64/7206	0.0264202560493
ko05321	Inflammatory bowel disease (IBD)	3/1158	56/7206	0.0268503526841
ko04916	Melanogenesis	33/1158	142/7206	0.0274262388074
ko04978	Mineral absorption	12/1158	40/7206	0.0274976296419
ko04722	Neurotrophin signaling pathway	36/1158	160/7206	0.0292920424505
ko05131	Shigellosis	6/1158	82/7206	0.0326928848367
ko00640	Propanoate metabolism	1/1158	34/7206	0.0334211722992
ko00860	Porphyrin and chlorophyll metabolism	1/1158	34/7206	0.0334211722992
ko04214	Apoptosis - fly	5/1158	72/7206	0.0347065279467
ko00310	Lysine degradation	5/1158	73/7206	0.0354056465024
ko04658	Th1 and Th2 cell differentiation	8/1158	96/7206	0.0356360159672
ko05144	Malaria	2/1158	45/7206	0.038470419225
ko04071	Sphingolipid signaling pathway	36/1158	162/7206	0.0390453691367
ko04350	TGF-beta signaling pathway	9/1158	103/7206	0.0419956899469
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1158	92/7206	0.0452032982886
ko05230	Central carbon metabolism in cancer	20/1158	81/7206	0.046119514734
ko04114	Oocyte meiosis	31/1158	139/7206	0.0474942967319