ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 25/351 80/7206 2.09290071187e-14 ko04728 Dopaminergic synapse 32/351 185/7206 2.2109512529e-10 ko04727 GABAergic synapse 24/351 110/7206 3.31769666716e-10 ko05033 Nicotine addiction 17/351 56/7206 5.73004384045e-10 ko04724 Glutamatergic synapse 28/351 152/7206 7.05097901879e-10 ko04080 Neuroactive ligand-receptor interaction 46/351 423/7206 2.57543433933e-07 ko04723 Retrograde endocannabinoid signaling 26/351 175/7206 2.83801865359e-07 ko05032 Morphine addiction 18/351 110/7206 5.03099518094e-06 ko04360 Axon guidance 28/351 233/7206 7.6126375186e-06 ko04713 Circadian entrainment 20/351 136/7206 8.12384552256e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 14/351 74/7206 1.03553391287e-05 ko04911 Insulin secretion 18/351 117/7206 1.22527863821e-05 ko04725 Cholinergic synapse 21/351 160/7206 2.88540017899e-05 ko04145 Phagosome 21/351 162/7206 3.4853596919e-05 ko04514 Cell adhesion molecules (CAMs) 17/351 130/7206 0.000174149425533 ko04261 Adrenergic signaling in cardiomyocytes 23/351 205/7206 0.000176899242674 ko04966 Collecting duct acid secretion 7/351 26/7206 0.000180312739704 ko05120 Epithelial cell signaling in Helicobacter pylori infection 13/351 92/7206 0.000471005527394 ko04961 Endocrine and other factor-regulated calcium reabsorption 10/351 59/7206 0.000490286838256 ko05030 Cocaine addiction 11/351 73/7206 0.00073440980566 ko05110 Vibrio cholerae infection 10/351 63/7206 0.000838714820801 ko04010 MAPK signaling pathway 29/351 321/7206 0.00123106302902 ko04970 Salivary secretion 12/351 95/7206 0.00209143615025 ko04964 Proximal tubule bicarbonate reclamation 6/351 29/7206 0.00234212392717 ko04972 Pancreatic secretion 13/351 111/7206 0.00275152222846 ko05031 Amphetamine addiction 11/351 91/7206 0.00447152426199 ko05322 Systemic lupus erythematosus 1/351 151/7206 0.00703841354402 ko04726 Serotonergic synapse 14/351 137/7206 0.00766870808253 ko04071 Sphingolipid signaling pathway 16/351 162/7206 0.00802951733279 ko05016 Huntington's disease 3/351 215/7206 0.00974834524505 ko05203 Viral carcinogenesis 5/351 277/7206 0.010191770485 ko03040 Spliceosome 1/351 145/7206 0.0102270387119 ko05323 Rheumatoid arthritis 10/351 89/7206 0.0109076408816 ko04391 Hippo signaling pathway - fly 10/351 90/7206 0.0117579984052 ko04950 Maturity onset diabetes of the young 5/351 29/7206 0.0120428052053 ko05168 Herpes simplex infection 2/351 182/7206 0.0129095757956 ko04730 Long-term depression 9/351 78/7206 0.0130475707882 ko04015 Rap1 signaling pathway 23/351 278/7206 0.0144732820551 ko04024 cAMP signaling pathway 23/351 279/7206 0.0146428699374 ko04120 Ubiquitin mediated proteolysis 1/351 138/7206 0.0149029225692 ko05164 Influenza A 2/351 167/7206 0.0175235743408 ko01200 Carbon metabolism 1/351 128/7206 0.0213671494392 ko03013 RNA transport 2/351 166/7206 0.0258456840717 ko00604 Glycosphingolipid biosynthesis - ganglio series 3/351 14/7206 0.0279443404431 ko00430 Taurine and hypotaurine metabolism 3/351 14/7206 0.0279443404431 ko04211 Longevity regulating pathway 1/351 123/7206 0.0314309662356 ko02024 Quorum sensing 3/351 15/7206 0.0336996187297 ko04540 Gap junction 12/351 128/7206 0.0338453402669 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/351 182/7206 0.0355773023543 ko04141 Protein processing in endoplasmic reticulum 3/351 184/7206 0.0357426760245 ko04530 Tight junction 18/351 228/7206 0.040437770668 ko04978 Mineral absorption 5/351 40/7206 0.043272099416 ko04510 Focal adhesion 5/351 240/7206 0.0452769231626 ko04930 Type II diabetes mellitus 6/351 54/7206 0.0461933684647 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/351 1/7206 0.048709408826 ko04217 Necroptosis 3/351 178/7206 0.0496169369364