ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 29/340 191/7206 1.70364597156e-08 ko04621 NOD-like receptor signaling pathway 24/340 157/7206 2.68823758847e-07 ko04380 Osteoclast differentiation 21/340 134/7206 1.00619772718e-06 ko00643 Styrene degradation 4/340 4/7206 4.87315084117e-06 ko04668 TNF signaling pathway 18/340 120/7206 1.13460736837e-05 ko05164 Influenza A 21/340 167/7206 3.44578585534e-05 ko04064 NF-kappa B signaling pathway 15/340 96/7206 3.75868814434e-05 ko04657 IL-17 signaling pathway 14/340 87/7206 4.87678136229e-05 ko04666 Fc gamma R-mediated phagocytosis 17/340 122/7206 5.26636902701e-05 ko00350 Tyrosine metabolism 8/340 33/7206 0.000111272916194 ko05133 Pertussis 13/340 87/7206 0.000196655888158 ko05160 Hepatitis C 18/340 153/7206 0.000292374580741 ko05131 Shigellosis 12/340 82/7206 0.000419977960734 ko04974 Protein digestion and absorption 13/340 96/7206 0.000528713606024 ko04623 Cytosolic DNA-sensing pathway 8/340 41/7206 0.000550337655626 ko04650 Natural killer cell mediated cytotoxicity 13/340 97/7206 0.000585109514583 ko00983 Drug metabolism - other enzymes 8/340 42/7206 0.000652396920153 ko04662 B cell receptor signaling pathway 12/340 88/7206 0.000807416417275 ko05323 Rheumatoid arthritis 12/340 89/7206 0.000894578019698 ko05034 Alcoholism 2/340 238/7206 0.00152656365713 ko00120 Primary bile acid biosynthesis 5/340 20/7206 0.00195680213259 ko05132 Salmonella infection 12/340 98/7206 0.00209293614503 ko04622 RIG-I-like receptor signaling pathway 9/340 62/7206 0.00230962667925 ko05134 Legionellosis 10/340 74/7206 0.00232491294812 ko04620 Toll-like receptor signaling pathway 12/340 100/7206 0.00248744558365 ko00140 Steroid hormone biosynthesis 7/340 41/7206 0.00274629750667 ko04080 Neuroactive ligand-receptor interaction 8/340 423/7206 0.00286604853361 ko04723 Retrograde endocannabinoid signaling 1/340 175/7206 0.0033440119141 ko04610 Complement and coagulation cascades 10/340 79/7206 0.00378599712181 ko04976 Bile secretion 10/340 80/7206 0.00415061655993 ko04630 Jak-STAT signaling pathway 14/340 132/7206 0.00521466647262 ko05150 Staphylococcus aureus infection 6/340 36/7206 0.00618880146051 ko04210 Apoptosis 17/340 180/7206 0.00629098493969 ko00360 Phenylalanine metabolism 4/340 17/7206 0.00710680566491 ko04660 T cell receptor signaling pathway 13/340 124/7206 0.00785143687611 ko05161 Hepatitis B 16/340 173/7206 0.00950980007609 ko04724 Glutamatergic synapse 1/340 152/7206 0.0104130497563 ko04141 Protein processing in endoplasmic reticulum 2/340 184/7206 0.012524256987 ko04728 Dopaminergic synapse 2/340 185/7206 0.0125973105325 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/340 11/7206 0.0129453830442 ko04390 Hippo signaling pathway 2/340 188/7206 0.0129618210735 ko04014 Ras signaling pathway 5/340 279/7206 0.0138087793239 ko04114 Oocyte meiosis 1/340 139/7206 0.0148258116443 ko04670 Leukocyte transendothelial migration 14/340 151/7206 0.0170762558891 ko04062 Chemokine signaling pathway 17/340 201/7206 0.0171675939375 ko05144 Malaria 6/340 45/7206 0.0181615316837 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/340 5/7206 0.0201888913148 ko04713 Circadian entrainment 1/340 136/7206 0.0219813679697 ko04215 Apoptosis - multiple species 6/340 47/7206 0.0221405669435 ko04726 Serotonergic synapse 1/340 137/7206 0.0222421005211 ko05140 Leishmaniasis 8/340 75/7206 0.0243095764954 ko05204 Chemical carcinogenesis 6/340 48/7206 0.02433445493 ko04550 Signaling pathways regulating pluripotency of stem cells 2/340 165/7206 0.0247417554569 ko04664 Fc epsilon RI signaling pathway 8/340 77/7206 0.0279757212927 ko05162 Measles 11/340 120/7206 0.0286472015581 ko04217 Necroptosis 15/340 178/7206 0.0290114428213 ko00380 Tryptophan metabolism 6/340 50/7206 0.0291478641618 ko00362 Benzoate degradation 2/340 6/7206 0.029347361673 ko05168 Herpes simplex infection 15/340 182/7206 0.0318362843045 ko04932 Non-alcoholic fatty liver disease (NAFLD) 15/340 182/7206 0.0318362843045 ko04540 Gap junction 1/340 128/7206 0.0318552854522 ko04972 Pancreatic secretion 10/340 111/7206 0.040665541948 ko00051 Fructose and mannose metabolism 5/340 42/7206 0.046194153533 ko00830 Retinol metabolism 5/340 42/7206 0.046194153533 ko00401 Novobiocin biosynthesis 1/340 1/7206 0.0471829031365 ko05321 Inflammatory bowel disease (IBD) 6/340 56/7206 0.0471871753893 ko04310 Wnt signaling pathway 3/340 181/7206 0.0490015490757