ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 55/335 145/7206 6.97639314874e-37 ko03008 Ribosome biogenesis in eukaryotes 31/335 79/7206 1.44885687739e-21 ko04110 Cell cycle 36/335 145/7206 2.6254510671e-17 ko04111 Cell cycle - yeast 26/335 90/7206 1.66752639617e-14 ko03013 RNA transport 33/335 166/7206 5.81768978863e-13 ko03460 Fanconi anemia pathway 16/335 51/7206 5.42726229139e-10 ko03030 DNA replication 14/335 38/7206 5.90317850007e-10 ko04113 Meiosis - yeast 17/335 70/7206 1.22580322587e-08 ko03440 Homologous recombination 13/335 41/7206 2.03387613501e-08 ko03410 Base excision repair 12/335 38/7206 7.60501654719e-08 ko00240 Pyrimidine metabolism 19/335 110/7206 5.78260209249e-07 ko03430 Mismatch repair 8/335 22/7206 3.62102042522e-06 ko04144 Endocytosis 2/335 342/7206 1.71354991158e-05 ko03015 mRNA surveillance pathway 15/335 93/7206 2.14460004422e-05 ko04151 PI3K-Akt signaling pathway 4/335 390/7206 9.45794472843e-05 ko03018 RNA degradation 13/335 84/7206 0.00011776473731 ko03420 Nucleotide excision repair 9/335 46/7206 0.000218123443517 ko03020 RNA polymerase 7/335 29/7206 0.000283356775789 ko04810 Regulation of actin cytoskeleton 2/335 264/7206 0.000500579724359 ko04261 Adrenergic signaling in cardiomyocytes 1/335 205/7206 0.00108674281043 ko04024 cAMP signaling pathway 3/335 279/7206 0.00127377894544 ko04014 Ras signaling pathway 3/335 279/7206 0.00127377894544 ko05166 HTLV-I infection 26/335 292/7206 0.00147895360041 ko04510 Focal adhesion 2/335 240/7206 0.00150747244191 ko04072 Phospholipase D signaling pathway 1/335 197/7206 0.00159670220845 ko05205 Proteoglycans in cancer 3/335 271/7206 0.00180106262798 ko04114 Oocyte meiosis 15/335 139/7206 0.0019243068338 ko04530 Tight junction 2/335 228/7206 0.00213599331303 ko04728 Dopaminergic synapse 1/335 185/7206 0.00229245356316 ko05152 Tuberculosis 1/335 187/7206 0.0023059967987 ko04060 Cytokine-cytokine receptor interaction 1/335 191/7206 0.00240718997696 ko04371 Apelin signaling pathway 1/335 177/7206 0.00334417719096 ko03022 Basal transcription factors 7/335 44/7206 0.00382134982173 ko04022 cGMP-PKG signaling pathway 2/335 216/7206 0.0044918729968 ko04723 Retrograde endocannabinoid signaling 1/335 175/7206 0.00519480301883 ko04015 Rap1 signaling pathway 4/335 278/7206 0.00537495110746 ko04921 Oxytocin signaling pathway 2/335 209/7206 0.00652859473419 ko04725 Cholinergic synapse 1/335 160/7206 0.00707492905995 ko04145 Phagosome 1/335 162/7206 0.00714137974729 ko04360 Axon guidance 3/335 233/7206 0.0101494972093 ko04724 Glutamatergic synapse 1/335 152/7206 0.0102799152301 ko05012 Parkinson's disease 1/335 155/7206 0.0105034445686 ko04120 Ubiquitin mediated proteolysis 13/335 138/7206 0.0129784283899 ko00230 Purine metabolism 17/335 194/7206 0.0135970097329 ko04010 MAPK signaling pathway 6/335 321/7206 0.0136453865617 ko04217 Necroptosis 2/335 178/7206 0.0177018382561 ko04115 p53 signaling pathway 8/335 74/7206 0.0208907485453 ko04380 Osteoclast differentiation 1/335 134/7206 0.0214554245375 ko05231 Choline metabolism in cancer 1/335 134/7206 0.0214554245375 ko04933 AGE-RAGE signaling pathway in diabetic complications 1/335 135/7206 0.0215216797628 ko04713 Circadian entrainment 1/335 136/7206 0.0216350682922 ko04726 Serotonergic synapse 1/335 137/7206 0.0217956514389 ko04218 Cellular senescence 15/335 177/7206 0.0271106120533 ko04914 Progesterone-mediated oocyte maturation 10/335 104/7206 0.0291117356362 ko05145 Toxoplasmosis 1/335 126/7206 0.0309863686437 ko04540 Gap junction 1/335 128/7206 0.0313269830087 ko05142 Chagas disease (American trypanosomiasis) 1/335 130/7206 0.0319265629011 ko04915 Estrogen signaling pathway 1/335 131/7206 0.032323465426 ko04722 Neurotrophin signaling pathway 2/335 160/7206 0.0348749316618 ko04071 Sphingolipid signaling pathway 2/335 162/7206 0.0352669270633 ko04611 Platelet activation 2/335 163/7206 0.0355466645648 ko05169 Epstein-Barr virus infection 16/335 206/7206 0.0416909020857 ko04911 Insulin secretion 1/335 117/7206 0.0445251038874 ko04666 Fc gamma R-mediated phagocytosis 1/335 122/7206 0.0462372969685 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/335 182/7206 0.0488458751981 ko05160 Hepatitis C 2/335 153/7206 0.0492140147739