ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	212/1325	423/7206	3.57023988324e-53
ko04724	Glutamatergic synapse	96/1325	152/7206	6.74007847149e-35
ko05032	Morphine addiction	74/1325	110/7206	9.33060256584e-30
ko05033	Nicotine addiction	49/1325	56/7206	2.65330534192e-29
ko04727	GABAergic synapse	72/1325	110/7206	7.88323145058e-28
ko04713	Circadian entrainment	80/1325	136/7206	3.40010260769e-26
ko04721	Synaptic vesicle cycle	52/1325	80/7206	3.33960590334e-20
ko04725	Cholinergic synapse	80/1325	160/7206	4.46423147682e-20
ko04728	Dopaminergic synapse	86/1325	185/7206	6.97898782542e-19
ko04024	cAMP signaling pathway	113/1325	279/7206	1.96568589522e-18
ko04020	Calcium signaling pathway	107/1325	265/7206	1.49424234724e-17
ko04723	Retrograde endocannabinoid signaling	80/1325	175/7206	4.19151391057e-17
ko04911	Insulin secretion	58/1325	117/7206	1.15230202048e-14
ko04744	Phototransduction	28/1325	36/7206	1.31750337855e-14
ko04726	Serotonergic synapse	63/1325	137/7206	7.1900906144e-14
ko04742	Taste transduction	37/1325	61/7206	2.3855501413e-13
ko04921	Oxytocin signaling pathway	82/1325	209/7206	1.09611626521e-12
ko05031	Amphetamine addiction	45/1325	91/7206	1.27647644149e-11
ko04970	Salivary secretion	45/1325	95/7206	8.17667916159e-11
ko03040	Spliceosome	2/1325	145/7206	1.3731836972e-10
ko03010	Ribosome	1/1325	129/7206	2.08678640356e-10
ko04261	Adrenergic signaling in cardiomyocytes	75/1325	205/7206	3.77888630744e-10
ko04720	Long-term potentiation	45/1325	99/7206	4.5105172284e-10
ko04740	Olfactory transduction	37/1325	80/7206	8.99816871807e-09
ko04925	Aldosterone synthesis and secretion	43/1325	105/7206	6.24840867008e-08
ko04022	cGMP-PKG signaling pathway	72/1325	216/7206	9.12279588288e-08
ko05168	Herpes simplex infection	9/1325	182/7206	1.0164246958e-07
ko05322	Systemic lupus erythematosus	6/1325	151/7206	1.82682052613e-07
ko04360	Axon guidance	75/1325	233/7206	2.6986104774e-07
ko04621	NOD-like receptor signaling pathway	7/1325	157/7206	3.29236522765e-07
ko03013	RNA transport	8/1325	166/7206	4.0114970464e-07
ko05030	Cocaine addiction	32/1325	73/7206	4.20086218674e-07
ko04966	Collecting duct acid secretion	16/1325	26/7206	1.2929899129e-06
ko04971	Gastric acid secretion	38/1325	98/7206	2.08727359889e-06
ko05203	Viral carcinogenesis	23/1325	277/7206	2.44662652929e-06
ko04070	Phosphatidylinositol signaling system	41/1325	112/7206	5.64778872609e-06
ko04060	Cytokine-cytokine receptor interaction	13/1325	191/7206	6.46811916079e-06
ko04110	Cell cycle	8/1325	145/7206	1.04279741511e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1325	74/7206	1.16639230136e-05
ko05164	Influenza A	11/1325	167/7206	1.68037616005e-05
ko04141	Protein processing in endoplasmic reticulum	13/1325	184/7206	1.73094338542e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1325	79/7206	2.80510252894e-05
ko04972	Pancreatic secretion	39/1325	111/7206	3.15605758744e-05
ko04072	Phospholipase D signaling pathway	60/1325	197/7206	3.3535191255e-05
ko04010	MAPK signaling pathway	88/1325	321/7206	4.60131153118e-05
ko04976	Bile secretion	30/1325	80/7206	5.56914641648e-05
ko04014	Ras signaling pathway	78/1325	279/7206	7.20709783061e-05
ko04923	Regulation of lipolysis in adipocytes	29/1325	77/7206	7.52086496206e-05
ko04730	Long-term depression	29/1325	78/7206	8.6973924068e-05
ko04514	Cell adhesion molecules (CAMs)	42/1325	130/7206	0.00012992962302
ko04540	Gap junction	41/1325	128/7206	0.000187439776674
ko04924	Renin secretion	30/1325	86/7206	0.000223732369191
ko04612	Antigen processing and presentation	3/1325	77/7206	0.000289510848842
ko00520	Amino sugar and nucleotide sugar metabolism	1/1325	55/7206	0.000324353986005
ko04750	Inflammatory mediator regulation of TRP channels	39/1325	122/7206	0.000334667776227
ko05414	Dilated cardiomyopathy	36/1325	112/7206	0.000476684979273
ko04745	Phototransduction - fly	16/1325	38/7206	0.000583393333804
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1325	79/7206	0.000677978217805
ko05169	Epstein-Barr virus infection	20/1325	206/7206	0.000681059689896
ko04120	Ubiquitin mediated proteolysis	11/1325	138/7206	0.00078226889443
ko05110	Vibrio cholerae infection	23/1325	63/7206	0.000800501867086
ko04064	NF-kappa B signaling pathway	6/1325	96/7206	0.000837019042697
ko05205	Proteoglycans in cancer	30/1325	271/7206	0.00101224343146
ko04710	Circadian rhythm	17/1325	43/7206	0.00109855340609
ko00240	Pyrimidine metabolism	8/1325	110/7206	0.0011845566793
ko04915	Estrogen signaling pathway	39/1325	131/7206	0.00132273777885
ko05140	Leishmaniasis	4/1325	75/7206	0.00149428940882
ko00071	Fatty acid degradation	1/1325	45/7206	0.00173188783806
ko03420	Nucleotide excision repair	1/1325	46/7206	0.00174380065375
ko03022	Basal transcription factors	1/1325	44/7206	0.00267408763888
ko05162	Measles	10/1325	120/7206	0.00276731713968
ko04622	RIG-I-like receptor signaling pathway	3/1325	62/7206	0.00279827679358
ko04270	Vascular smooth muscle contraction	43/1325	154/7206	0.00311721422482
ko04610	Complement and coagulation cascades	5/1325	79/7206	0.00319687888232
ko04657	IL-17 signaling pathway	6/1325	87/7206	0.00322324761032
ko05133	Pertussis	6/1325	87/7206	0.00322324761032
ko04964	Proximal tubule bicarbonate reclamation	12/1325	29/7206	0.00334559506989
ko05145	Toxoplasmosis	11/1325	126/7206	0.00347799975756
ko04922	Glucagon signaling pathway	37/1325	128/7206	0.00368896980607
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1325	59/7206	0.00377759310189
ko04930	Type II diabetes mellitus	19/1325	54/7206	0.00389472814342
ko04371	Apelin signaling pathway	48/1325	177/7206	0.00414936620371
ko05161	Hepatitis B	18/1325	173/7206	0.00516864440069
ko00562	Inositol phosphate metabolism	27/1325	89/7206	0.00554400739732
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1325	14/7206	0.00718058960592
ko04658	Th1 and Th2 cell differentiation	8/1325	96/7206	0.00773379692832
ko04260	Cardiac muscle contraction	29/1325	98/7206	0.00799216196788
ko04146	Peroxisome	7/1325	89/7206	0.00828341848192
ko05321	Inflammatory bowel disease (IBD)	3/1325	56/7206	0.0084958568289
ko04214	Apoptosis - fly	5/1325	72/7206	0.00881229259839
ko04626	Plant-pathogen interaction	8/1325	18/7206	0.00973625968056
ko04217	Necroptosis	20/1325	178/7206	0.0107265425437
ko05144	Malaria	2/1325	45/7206	0.0111313842189
ko00280	Valine, leucine and isoleucine degradation	3/1325	54/7206	0.0123025275811
ko04330	Notch signaling pathway	4/1325	62/7206	0.012518963732
ko00860	Porphyrin and chlorophyll metabolism	1/1325	34/7206	0.0137145653014
ko00910	Nitrogen metabolism	8/1325	19/7206	0.0141551140423
ko03018	RNA degradation	7/1325	84/7206	0.015239475569
ko04630	Jak-STAT signaling pathway	14/1325	132/7206	0.0171650545766
ko04210	Apoptosis	21/1325	180/7206	0.0188973184637
ko05131	Shigellosis	7/1325	82/7206	0.0207234692537
ko04015	Rap1 signaling pathway	66/1325	278/7206	0.0218840846904
ko00310	Lysine degradation	6/1325	73/7206	0.0220521956698
ko04115	p53 signaling pathway	6/1325	74/7206	0.0223964537927
ko05231	Choline metabolism in cancer	35/1325	134/7206	0.024046381604
ko05219	Bladder cancer	3/1325	48/7206	0.0247142112411
ko05166	HTLV-I infection	39/1325	292/7206	0.0250030708439
ko04973	Carbohydrate digestion and absorption	14/1325	42/7206	0.0252149531493
ko04113	Meiosis - yeast	6/1325	70/7206	0.0299113208147
ko05320	Autoimmune thyroid disease	1/1325	29/7206	0.0311328887303
ko04912	GnRH signaling pathway	32/1325	122/7206	0.0329332793522
ko04062	Chemokine signaling pathway	49/1325	201/7206	0.0331426163458
ko04213	Longevity regulating pathway - multiple species	24/1325	86/7206	0.0342557459323
ko04918	Thyroid hormone synthesis	24/1325	86/7206	0.0342557459323
ko00480	Glutathione metabolism	4/1325	55/7206	0.0343420281737
ko00630	Glyoxylate and dicarboxylate metabolism	2/1325	38/7206	0.0345159690791
ko03410	Base excision repair	2/1325	38/7206	0.0345159690791
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1325	100/7206	0.0362995861459
ko04152	AMPK signaling pathway	40/1325	161/7206	0.0390735289077
ko05016	Huntington's disease	28/1325	215/7206	0.0396322680588
ko04962	Vasopressin-regulated water reabsorption	17/1325	58/7206	0.0398708533317
ko04960	Aldosterone-regulated sodium reabsorption	13/1325	41/7206	0.0402883714936
ko05217	Basal cell carcinoma	6/1325	68/7206	0.0403730947059
ko04350	TGF-beta signaling pathway	11/1325	103/7206	0.0404269971523
ko04510	Focal adhesion	32/1325	240/7206	0.0416530492875
ko04932	Non-alcoholic fatty liver disease (NAFLD)	23/1325	182/7206	0.0418336484197
ko04142	Lysosome	18/1325	151/7206	0.0429134329759
ko00330	Arginine and proline metabolism	5/1325	61/7206	0.044543767997
ko05012	Parkinson's disease	19/1325	155/7206	0.046374747112
ko00590	Arachidonic acid metabolism	4/1325	52/7206	0.0471780805564