ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	214/1283	423/7206	3.21947873619e-57
ko04724	Glutamatergic synapse	93/1283	152/7206	2.15434168204e-33
ko05033	Nicotine addiction	50/1283	56/7206	1.62086565859e-31
ko05032	Morphine addiction	72/1283	110/7206	9.47641389509e-29
ko04713	Circadian entrainment	79/1283	136/7206	2.42731002571e-26
ko04727	GABAergic synapse	69/1283	110/7206	6.14528725372e-26
ko04721	Synaptic vesicle cycle	54/1283	80/7206	8.34337746012e-23
ko04728	Dopaminergic synapse	88/1283	185/7206	4.21647794872e-21
ko04020	Calcium signaling pathway	111/1283	265/7206	8.84571773075e-21
ko04725	Cholinergic synapse	79/1283	160/7206	2.64851449176e-20
ko04024	cAMP signaling pathway	112/1283	279/7206	3.19747862431e-19
ko04723	Retrograde endocannabinoid signaling	80/1283	175/7206	5.7284784257e-18
ko04742	Taste transduction	39/1283	61/7206	1.36720636561e-15
ko04726	Serotonergic synapse	64/1283	137/7206	3.6015298803e-15
ko04744	Phototransduction	28/1283	36/7206	5.59238123811e-15
ko04911	Insulin secretion	57/1283	117/7206	1.20069712428e-14
ko04921	Oxytocin signaling pathway	83/1283	209/7206	4.78725962251e-14
ko04261	Adrenergic signaling in cardiomyocytes	78/1283	205/7206	3.15970266637e-12
ko04720	Long-term potentiation	47/1283	99/7206	8.59988143411e-12
ko03040	Spliceosome	1/1283	145/7206	1.58605182741e-11
ko05031	Amphetamine addiction	44/1283	91/7206	1.8450261539e-11
ko04970	Salivary secretion	45/1283	95/7206	2.64336702202e-11
ko04360	Axon guidance	79/1283	233/7206	1.69360780428e-09
ko04740	Olfactory transduction	36/1283	80/7206	1.45322355923e-08
ko04022	cGMP-PKG signaling pathway	72/1283	216/7206	2.14425674152e-08
ko05203	Viral carcinogenesis	18/1283	277/7206	3.52769299728e-08
ko03013	RNA transport	7/1283	166/7206	1.6569348844e-07
ko05030	Cocaine addiction	32/1283	73/7206	1.95564088279e-07
ko04925	Aldosterone synthesis and secretion	41/1283	105/7206	2.21019622359e-07
ko04971	Gastric acid secretion	39/1283	98/7206	3.05847329321e-07
ko05168	Herpes simplex infection	9/1283	182/7206	3.40690966528e-07
ko04540	Gap junction	46/1283	128/7206	9.21729175824e-07
ko04060	Cytokine-cytokine receptor interaction	11/1283	191/7206	1.15994563896e-06
ko05322	Systemic lupus erythematosus	7/1283	151/7206	1.56105993308e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1283	74/7206	3.9146364834e-06
ko04070	Phosphatidylinositol signaling system	40/1283	112/7206	4.70418451036e-06
ko04924	Renin secretion	33/1283	86/7206	5.62412229061e-06
ko04010	MAPK signaling pathway	89/1283	321/7206	6.54615257531e-06
ko04621	NOD-like receptor signaling pathway	9/1283	157/7206	1.1574103122e-05
ko04260	Cardiac muscle contraction	35/1283	98/7206	2.33292558825e-05
ko04141	Protein processing in endoplasmic reticulum	13/1283	184/7206	3.38544203922e-05
ko04966	Collecting duct acid secretion	14/1283	26/7206	3.41783566133e-05
ko05164	Influenza A	11/1283	167/7206	3.41826114899e-05
ko04072	Phospholipase D signaling pathway	58/1283	197/7206	4.34747136981e-05
ko04610	Complement and coagulation cascades	2/1283	79/7206	4.47574269151e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1283	79/7206	4.47574269151e-05
ko04972	Pancreatic secretion	37/1283	111/7206	7.74998225955e-05
ko05140	Leishmaniasis	2/1283	75/7206	0.000101480899686
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1283	59/7206	0.000106486338993
ko04745	Phototransduction - fly	17/1283	38/7206	0.000107529868004
ko04750	Inflammatory mediator regulation of TRP channels	39/1283	122/7206	0.000114984745965
ko04064	NF-kappa B signaling pathway	4/1283	96/7206	0.000122515982292
ko04730	Long-term depression	28/1283	78/7206	0.000133706000655
ko04371	Apelin signaling pathway	52/1283	177/7206	0.000134043309652
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1283	79/7206	0.000157287711294
ko05110	Vibrio cholerae infection	24/1283	63/7206	0.000166518719878
ko04120	Ubiquitin mediated proteolysis	9/1283	138/7206	0.000174516023893
ko05414	Dilated cardiomyopathy	36/1283	112/7206	0.000241257199676
ko04514	Cell adhesion molecules (CAMs)	40/1283	130/7206	0.000280975907251
ko05169	Epstein-Barr virus infection	18/1283	206/7206	0.000283677823248
ko05205	Proteoglycans in cancer	27/1283	271/7206	0.000343301789307
ko04146	Peroxisome	4/1283	89/7206	0.000377317032948
ko04014	Ras signaling pathway	73/1283	279/7206	0.000412401156641
ko00520	Amino sugar and nucleotide sugar metabolism	1/1283	55/7206	0.000531093954691
ko04110	Cell cycle	11/1283	145/7206	0.000599623452487
ko00240	Pyrimidine metabolism	7/1283	110/7206	0.000637867851466
ko04915	Estrogen signaling pathway	39/1283	131/7206	0.000727039718945
ko04923	Regulation of lipolysis in adipocytes	26/1283	77/7206	0.000766397190564
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1283	14/7206	0.00107246790212
ko00330	Arginine and proline metabolism	2/1283	61/7206	0.0011190435973
ko05162	Measles	9/1283	120/7206	0.00163337524409
ko04976	Bile secretion	26/1283	80/7206	0.00167578370338
ko04626	Plant-pathogen interaction	9/1283	18/7206	0.00181529027722
ko04612	Antigen processing and presentation	4/1283	77/7206	0.00231240889862
ko05321	Inflammatory bowel disease (IBD)	2/1283	56/7206	0.00244073703062
ko03022	Basal transcription factors	1/1283	44/7206	0.00272274368199
ko05144	Malaria	1/1283	45/7206	0.00272577350419
ko00071	Fatty acid degradation	1/1283	45/7206	0.00272577350419
ko03420	Nucleotide excision repair	1/1283	46/7206	0.00286060229455
ko00310	Lysine degradation	4/1283	73/7206	0.00316316367038
ko00480	Glutathione metabolism	2/1283	55/7206	0.00379776281487
ko04622	RIG-I-like receptor signaling pathway	3/1283	62/7206	0.0041753436626
ko05161	Hepatitis B	17/1283	173/7206	0.00461029383273
ko04657	IL-17 signaling pathway	6/1283	87/7206	0.00462455747375
ko05133	Pertussis	6/1283	87/7206	0.00462455747375
ko04214	Apoptosis - fly	4/1283	72/7206	0.00464917861271
ko00590	Arachidonic acid metabolism	2/1283	52/7206	0.00540900355623
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1283	40/7206	0.0061919286676
ko05145	Toxoplasmosis	11/1283	126/7206	0.00644558506053
ko00562	Inositol phosphate metabolism	26/1283	89/7206	0.00754819256398
ko05131	Shigellosis	6/1283	82/7206	0.00882091466405
ko03018	RNA degradation	6/1283	84/7206	0.0090140174381
ko04115	p53 signaling pathway	5/1283	74/7206	0.00903367637878
ko00982	Drug metabolism - cytochrome P450	1/1283	37/7206	0.00937048223745
ko00630	Glyoxylate and dicarboxylate metabolism	1/1283	38/7206	0.00938722330968
ko04918	Thyroid hormone synthesis	25/1283	86/7206	0.00994425664314
ko04964	Proximal tubule bicarbonate reclamation	11/1283	29/7206	0.0115886926034
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1283	100/7206	0.0116544116781
ko04922	Glucagon signaling pathway	34/1283	128/7206	0.0137246406654
ko04658	Th1 and Th2 cell differentiation	8/1283	96/7206	0.0147184138723
ko04015	Rap1 signaling pathway	65/1283	278/7206	0.0162488325342
ko03320	PPAR signaling pathway	5/1283	69/7206	0.0173526456413
ko04270	Vascular smooth muscle contraction	39/1283	154/7206	0.018617874253
ko04912	GnRH signaling pathway	32/1283	122/7206	0.0224752382502
ko01524	Platinum drug resistance	6/1283	76/7206	0.0226636551553
ko00140	Steroid hormone biosynthesis	2/1283	41/7206	0.0242520235645
ko00983	Drug metabolism - other enzymes	2/1283	42/7206	0.024363434034
ko00380	Tryptophan metabolism	3/1283	50/7206	0.0251928056165
ko04916	Melanogenesis	36/1283	142/7206	0.0259190297274
ko05166	HTLV-I infection	38/1283	292/7206	0.0286181585206
ko04630	Jak-STAT signaling pathway	14/1283	132/7206	0.0286688905279
ko05231	Choline metabolism in cancer	34/1283	134/7206	0.0294603144849
ko04930	Type II diabetes mellitus	16/1283	54/7206	0.0307503089567
ko05340	Primary immunodeficiency	1/1283	30/7206	0.0316850535887
ko04640	Hematopoietic cell lineage	5/1283	64/7206	0.0327466685472
ko04213	Longevity regulating pathway - multiple species	23/1283	86/7206	0.0335975843204
ko05204	Chemical carcinogenesis	3/1283	48/7206	0.0358070614424
ko00260	Glycine, serine and threonine metabolism	3/1283	48/7206	0.0358070614424
ko04217	Necroptosis	21/1283	178/7206	0.0366293261472
ko04973	Carbohydrate digestion and absorption	13/1283	42/7206	0.0398530912754
ko04710	Circadian rhythm	13/1283	43/7206	0.0434843649233
ko04114	Oocyte meiosis	34/1283	139/7206	0.0436193284866
ko00600	Sphingolipid metabolism	5/1283	63/7206	0.0452820588614
ko05132	Salmonella infection	10/1283	98/7206	0.0462971750297
ko04620	Toll-like receptor signaling pathway	10/1283	100/7206	0.0470066187599
ko05320	Autoimmune thyroid disease	1/1283	29/7206	0.0480817861597
ko00280	Valine, leucine and isoleucine degradation	4/1283	54/7206	0.0480838925139