ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	198/1095	423/7206	8.58933600233e-58
ko04724	Glutamatergic synapse	89/1095	152/7206	1.90647911521e-35
ko05033	Nicotine addiction	49/1095	56/7206	2.49535123697e-33
ko04713	Circadian entrainment	77/1095	136/7206	2.15578160621e-29
ko04727	GABAergic synapse	66/1095	110/7206	2.30621963623e-27
ko05032	Morphine addiction	64/1095	110/7206	1.67303127137e-25
ko04728	Dopaminergic synapse	87/1095	185/7206	2.35179806579e-25
ko04725	Cholinergic synapse	77/1095	160/7206	2.47136168126e-23
ko04721	Synaptic vesicle cycle	50/1095	80/7206	3.9751841543e-22
ko04723	Retrograde endocannabinoid signaling	77/1095	175/7206	2.46682853291e-20
ko04020	Calcium signaling pathway	98/1095	265/7206	5.75711408595e-19
ko04024	cAMP signaling pathway	101/1095	279/7206	1.08160534303e-18
ko04921	Oxytocin signaling pathway	82/1095	209/7206	7.66881260177e-18
ko04911	Insulin secretion	56/1095	117/7206	3.96282806516e-17
ko04726	Serotonergic synapse	61/1095	137/7206	1.22296684473e-16
ko04742	Taste transduction	37/1095	61/7206	4.50421041485e-16
ko04720	Long-term potentiation	49/1095	99/7206	6.95766141432e-16
ko05031	Amphetamine addiction	45/1095	91/7206	1.13495684069e-14
ko04744	Phototransduction	26/1095	36/7206	2.22757369539e-14
ko04970	Salivary secretion	43/1095	95/7206	2.13528052576e-12
ko04261	Adrenergic signaling in cardiomyocytes	71/1095	205/7206	2.96925438704e-12
ko04740	Olfactory transduction	38/1095	80/7206	6.67269402073e-12
ko03040	Spliceosome	1/1095	145/7206	1.36060424821e-09
ko04925	Aldosterone synthesis and secretion	41/1095	105/7206	1.84037352437e-09
ko05168	Herpes simplex infection	4/1095	182/7206	6.53728654615e-09
ko04971	Gastric acid secretion	38/1095	98/7206	9.10267042573e-09
ko05203	Viral carcinogenesis	12/1095	277/7206	9.82501184998e-09
ko05030	Cocaine addiction	31/1095	73/7206	1.72771706634e-08
ko04360	Axon guidance	68/1095	233/7206	4.07245424268e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1095	74/7206	4.02050693324e-07
ko04010	MAPK signaling pathway	83/1095	321/7206	4.03145278754e-07
ko04540	Gap junction	42/1095	128/7206	5.63223406299e-07
ko04022	cGMP-PKG signaling pathway	61/1095	216/7206	6.11654783525e-07
ko04730	Long-term depression	29/1095	78/7206	1.46113191176e-06
ko04060	Cytokine-cytokine receptor interaction	8/1095	191/7206	1.74423304242e-06
ko04745	Phototransduction - fly	18/1095	38/7206	2.63410577794e-06
ko05322	Systemic lupus erythematosus	5/1095	151/7206	3.04079133514e-06
ko04924	Renin secretion	30/1095	86/7206	5.11208793448e-06
ko04966	Collecting duct acid secretion	14/1095	26/7206	5.16978152783e-06
ko03013	RNA transport	7/1095	166/7206	8.92569965378e-06
ko05164	Influenza A	7/1095	167/7206	9.0842328822e-06
ko04972	Pancreatic secretion	35/1095	111/7206	1.2182523913e-05
ko04260	Cardiac muscle contraction	32/1095	98/7206	1.22822757632e-05
ko04070	Phosphatidylinositol signaling system	35/1095	112/7206	1.43433288561e-05
ko04750	Inflammatory mediator regulation of TRP channels	37/1095	122/7206	1.8339966245e-05
ko04120	Ubiquitin mediated proteolysis	5/1095	138/7206	1.96037872548e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1095	79/7206	2.25060680875e-05
ko05110	Vibrio cholerae infection	23/1095	63/7206	2.49881242197e-05
ko04621	NOD-like receptor signaling pathway	7/1095	157/7206	2.56417818676e-05
ko04514	Cell adhesion molecules (CAMs)	38/1095	130/7206	3.55657464547e-05
ko04141	Protein processing in endoplasmic reticulum	10/1095	184/7206	4.26854012488e-05
ko04072	Phospholipase D signaling pathway	52/1095	197/7206	4.54415778842e-05
ko04610	Complement and coagulation cascades	1/1095	79/7206	5.18821530215e-05
ko04612	Antigen processing and presentation	1/1095	77/7206	7.96650811881e-05
ko04014	Ras signaling pathway	67/1095	279/7206	8.08687160632e-05
ko05169	Epstein-Barr virus infection	13/1095	206/7206	0.000107274505731
ko04915	Estrogen signaling pathway	37/1095	131/7206	0.000109772807803
ko04214	Apoptosis - fly	1/1095	72/7206	0.000184415203297
ko05414	Dilated cardiomyopathy	32/1095	112/7206	0.000266502942747
ko04912	GnRH signaling pathway	34/1095	122/7206	0.000295753597366
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1095	59/7206	0.000326720993665
ko04110	Cell cycle	8/1095	145/7206	0.000400676211752
ko03008	Ribosome biogenesis in eukaryotes	2/1095	79/7206	0.000409376456504
ko04626	Plant-pathogen interaction	9/1095	18/7206	0.000553939732186
ko04371	Apelin signaling pathway	44/1095	177/7206	0.000633335144462
ko04976	Bile secretion	24/1095	80/7206	0.000761797920145
ko00480	Glutathione metabolism	1/1095	55/7206	0.00208649618609
ko04964	Proximal tubule bicarbonate reclamation	11/1095	29/7206	0.00234220642188
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1095	14/7206	0.00235854181899
ko05205	Proteoglycans in cancer	24/1095	271/7206	0.00241343844753
ko04146	Peroxisome	4/1095	89/7206	0.00258778468087
ko05162	Measles	7/1095	120/7206	0.00283437634378
ko04916	Melanogenesis	35/1095	142/7206	0.00291049305216
ko00590	Arachidonic acid metabolism	1/1095	52/7206	0.0031201765101
ko05140	Leishmaniasis	3/1095	75/7206	0.00331808129636
ko04064	NF-kappa B signaling pathway	5/1095	96/7206	0.00379727734829
ko04330	Notch signaling pathway	2/1095	62/7206	0.00411434307571
ko00310	Lysine degradation	3/1095	73/7206	0.0047753099368
ko04015	Rap1 signaling pathway	59/1095	278/7206	0.00621468888992
ko00240	Pyrimidine metabolism	7/1095	110/7206	0.00696732036981
ko03420	Nucleotide excision repair	1/1095	46/7206	0.00700496917437
ko04973	Carbohydrate digestion and absorption	13/1095	42/7206	0.0084285265655
ko05166	HTLV-I infection	29/1095	292/7206	0.00966873241522
ko04657	IL-17 signaling pathway	5/1095	87/7206	0.0100906972766
ko00562	Inositol phosphate metabolism	23/1095	89/7206	0.0105207007449
ko05214	Glioma	21/1095	79/7206	0.0105310229252
ko05144	Malaria	1/1095	45/7206	0.0106618677997
ko00071	Fatty acid degradation	1/1095	45/7206	0.0106618677997
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1095	100/7206	0.0106802618018
ko04114	Oocyte meiosis	32/1095	139/7206	0.0121760241409
ko05321	Inflammatory bowel disease (IBD)	2/1095	56/7206	0.0132804491977
ko05161	Hepatitis B	15/1095	173/7206	0.0134071216536
ko04640	Hematopoietic cell lineage	3/1095	64/7206	0.0137493822588
ko03018	RNA degradation	5/1095	84/7206	0.0138897794658
ko05231	Choline metabolism in cancer	31/1095	134/7206	0.0144682397697
ko04923	Regulation of lipolysis in adipocytes	20/1095	77/7206	0.0152074541011
ko04062	Chemokine signaling pathway	43/1095	201/7206	0.016507375658
ko05131	Shigellosis	5/1095	82/7206	0.0192081286384
ko04217	Necroptosis	16/1095	178/7206	0.0194623812443
ko04622	RIG-I-like receptor signaling pathway	3/1095	62/7206	0.0195842940682
ko04930	Type II diabetes mellitus	15/1095	54/7206	0.0199538247111
ko04142	Lysosome	13/1095	151/7206	0.0214488812549
ko04270	Vascular smooth muscle contraction	34/1095	154/7206	0.0225091415634
ko00630	Glyoxylate and dicarboxylate metabolism	1/1095	38/7206	0.0230994668559
ko03410	Base excision repair	1/1095	38/7206	0.0230994668559
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1095	40/7206	0.0240186803047
ko04922	Glucagon signaling pathway	29/1095	128/7206	0.0244636928417
ko00260	Glycine, serine and threonine metabolism	2/1095	48/7206	0.0264287118101
ko04071	Sphingolipid signaling pathway	35/1095	162/7206	0.0264346261949
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1095	92/7206	0.0270735251319
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1095	182/7206	0.0274035912578
ko05010	Alzheimer's disease	42/1095	202/7206	0.0285650037942
ko00512	Mucin type O-glycan biosynthesis	9/1095	29/7206	0.0322116578913
ko04722	Neurotrophin signaling pathway	34/1095	160/7206	0.0344698360308
ko00982	Drug metabolism - cytochrome P450	1/1095	37/7206	0.0352048846221
ko01524	Platinum drug resistance	5/1095	76/7206	0.0355434017074
ko04350	TGF-beta signaling pathway	8/1095	103/7206	0.0368797177141
ko04668	TNF signaling pathway	10/1095	120/7206	0.0389847927602
ko05016	Huntington's disease	22/1095	215/7206	0.0422707159289
ko05230	Central carbon metabolism in cancer	19/1095	81/7206	0.0429533448562
ko05145	Toxoplasmosis	11/1095	126/7206	0.0442507077298
ko04960	Aldosterone-regulated sodium reabsorption	11/1095	41/7206	0.0477143453838
ko04918	Thyroid hormone synthesis	20/1095	86/7206	0.0477774766655
ko04115	p53 signaling pathway	5/1095	74/7206	0.0487324288731