ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 139/791 423/7206 2.81512163572e-36 ko04724 Glutamatergic synapse 66/791 152/7206 4.28197098692e-25 ko05033 Nicotine addiction 37/791 56/7206 7.99312488465e-23 ko05032 Morphine addiction 49/791 110/7206 1.82164724836e-19 ko04721 Synaptic vesicle cycle 41/791 80/7206 2.77822509248e-19 ko04728 Dopaminergic synapse 63/791 185/7206 1.78014118322e-17 ko04727 GABAergic synapse 46/791 110/7206 5.11679703769e-17 ko04713 Circadian entrainment 50/791 136/7206 1.23919433617e-15 ko04723 Retrograde endocannabinoid signaling 57/791 175/7206 6.23313472306e-15 ko04725 Cholinergic synapse 52/791 160/7206 1.11659897189e-13 ko04024 cAMP signaling pathway 73/791 279/7206 4.92926697177e-13 ko04726 Serotonergic synapse 45/791 137/7206 3.50926514231e-12 ko04911 Insulin secretion 40/791 117/7206 1.38342150505e-11 ko04020 Calcium signaling pathway 65/791 265/7206 1.6768453609e-10 ko05031 Amphetamine addiction 32/791 91/7206 6.97155474332e-10 ko04921 Oxytocin signaling pathway 54/791 209/7206 1.31199914942e-09 ko04742 Taste transduction 24/791 61/7206 7.47169343756e-09 ko04261 Adrenergic signaling in cardiomyocytes 49/791 205/7206 8.49732958536e-08 ko04720 Long-term potentiation 30/791 99/7206 1.16929207209e-07 ko04970 Salivary secretion 29/791 95/7206 1.59351186746e-07 ko04966 Collecting duct acid secretion 13/791 26/7206 8.11318968165e-07 ko03040 Spliceosome 1/791 145/7206 1.30847966604e-06 ko05203 Viral carcinogenesis 9/791 277/7206 2.95641242026e-06 ko05030 Cocaine addiction 22/791 73/7206 6.31891725362e-06 ko05110 Vibrio cholerae infection 20/791 63/7206 6.92518235686e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 22/791 74/7206 8.0784454424e-06 ko05164 Influenza A 3/791 167/7206 8.15654702674e-06 ko05322 Systemic lupus erythematosus 2/791 151/7206 8.22963483015e-06 ko03010 Ribosome 1/791 129/7206 1.06332100463e-05 ko04514 Cell adhesion molecules (CAMs) 32/791 130/7206 1.13087279244e-05 ko04971 Gastric acid secretion 26/791 98/7206 1.24783547763e-05 ko05168 Herpes simplex infection 5/791 182/7206 5.72443407676e-05 ko03013 RNA transport 4/791 166/7206 7.14023630728e-05 ko04745 Phototransduction - fly 13/791 38/7206 0.000120150955018 ko04972 Pancreatic secretion 26/791 111/7206 0.000158828140787 ko04120 Ubiquitin mediated proteolysis 3/791 138/7206 0.000161342427108 ko05162 Measles 2/791 120/7206 0.000174052025267 ko04925 Aldosterone synthesis and secretion 25/791 105/7206 0.000191741885787 ko04010 MAPK signaling pathway 57/791 321/7206 0.000228136266061 ko05166 HTLV-I infection 14/791 292/7206 0.000248308660094 ko04110 Cell cycle 4/791 145/7206 0.000402833324211 ko04964 Proximal tubule bicarbonate reclamation 10/791 29/7206 0.000682867253064 ko05169 Epstein-Barr virus infection 9/791 206/7206 0.00095656972353 ko05120 Epithelial cell signaling in Helicobacter pylori infection 21/791 92/7206 0.00105114806054 ko04070 Phosphatidylinositol signaling system 24/791 112/7206 0.00112868035786 ko04060 Cytokine-cytokine receptor interaction 8/791 191/7206 0.00135740937215 ko04961 Endocrine and other factor-regulated calcium reabsorption 15/791 59/7206 0.00137051101565 ko04014 Ras signaling pathway 48/791 279/7206 0.00163500703739 ko04730 Long-term depression 18/791 78/7206 0.00170881132028 ko04710 Circadian rhythm 12/791 43/7206 0.00172017046213 ko04022 cGMP-PKG signaling pathway 39/791 216/7206 0.00177828588445 ko04621 NOD-like receptor signaling pathway 6/791 157/7206 0.00178987261296 ko04750 Inflammatory mediator regulation of TRP channels 25/791 122/7206 0.00184164065162 ko04626 Plant-pathogen interaction 7/791 18/7206 0.00200249360541 ko04924 Renin secretion 19/791 86/7206 0.00256977689521 ko04612 Antigen processing and presentation 1/791 77/7206 0.00267148769749 ko04260 Cardiac muscle contraction 21/791 98/7206 0.00276021281689 ko04360 Axon guidance 40/791 233/7206 0.00378361027486 ko04540 Gap junction 25/791 128/7206 0.00385065129861 ko05161 Hepatitis B 8/791 173/7206 0.00437321654039 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 17/791 79/7206 0.00569181563177 ko04550 Signaling pathways regulating pluripotency of stem cells 8/791 165/7206 0.00781129016741 ko04922 Glucagon signaling pathway 24/791 128/7206 0.0092939724123 ko04978 Mineral absorption 10/791 40/7206 0.00948179264385 ko04610 Complement and coagulation cascades 2/791 79/7206 0.0103506254041 ko04960 Aldosterone-regulated sodium reabsorption 10/791 41/7206 0.0113414504214 ko04141 Protein processing in endoplasmic reticulum 10/791 184/7206 0.0117872044735 ko04330 Notch signaling pathway 1/791 62/7206 0.0125071720601 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/791 14/7206 0.0135122136682 ko05140 Leishmaniasis 2/791 75/7206 0.0147871901555 ko04071 Sphingolipid signaling pathway 28/791 162/7206 0.0148840471121 ko04510 Focal adhesion 15/791 240/7206 0.015326789552 ko04630 Jak-STAT signaling pathway 6/791 132/7206 0.0158207508903 ko04072 Phospholipase D signaling pathway 32/791 197/7206 0.0205759777361 ko00310 Lysine degradation 2/791 73/7206 0.0216870299086 ko05323 Rheumatoid arthritis 17/791 89/7206 0.0243192621585 ko04011 MAPK signaling pathway - yeast 1/791 53/7206 0.0263555437192 ko00280 Valine, leucine and isoleucine degradation 1/791 54/7206 0.0265906364661 ko00680 Methane metabolism 8/791 34/7206 0.0276902241332 ko05215 Prostate cancer 5/791 111/7206 0.0303501216626 ko04015 Rap1 signaling pathway 42/791 278/7206 0.0307958366531 ko00562 Inositol phosphate metabolism 16/791 89/7206 0.0401762306682 ko04611 Platelet activation 10/791 163/7206 0.0426534456844 ko04740 Olfactory transduction 15/791 80/7206 0.0448465214776 ko05414 Dilated cardiomyopathy 19/791 112/7206 0.0472792516067 ko05418 Fluid shear stress and atherosclerosis 11/791 173/7206 0.0485914860647