ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	196/1189	423/7206	3.9072957695e-50
ko04724	Glutamatergic synapse	90/1189	152/7206	1.91843447824e-33
ko05033	Nicotine addiction	47/1189	56/7206	1.26638302336e-28
ko05032	Morphine addiction	69/1189	110/7206	5.23798224444e-28
ko04713	Circadian entrainment	76/1189	136/7206	4.27315702104e-26
ko04727	GABAergic synapse	66/1189	110/7206	3.17780416159e-25
ko04721	Synaptic vesicle cycle	52/1189	80/7206	1.98811921296e-22
ko04728	Dopaminergic synapse	85/1189	185/7206	1.97329921546e-21
ko04725	Cholinergic synapse	77/1189	160/7206	4.90836487019e-21
ko04723	Retrograde endocannabinoid signaling	78/1189	175/7206	9.11725254358e-19
ko04024	cAMP signaling pathway	105/1189	279/7206	4.8721106113e-18
ko04020	Calcium signaling pathway	101/1189	265/7206	6.38310727832e-18
ko04911	Insulin secretion	55/1189	117/7206	8.48541757032e-15
ko04921	Oxytocin signaling pathway	80/1189	209/7206	1.49008762418e-14
ko04726	Serotonergic synapse	60/1189	137/7206	2.82031410835e-14
ko04742	Taste transduction	36/1189	61/7206	5.3995182623e-14
ko04744	Phototransduction	25/1189	36/7206	2.06497332671e-12
ko04261	Adrenergic signaling in cardiomyocytes	74/1189	205/7206	4.99949333576e-12
ko05031	Amphetamine addiction	42/1189	91/7206	2.79702386311e-11
ko04720	Long-term potentiation	44/1189	99/7206	4.5168763861e-11
ko04970	Salivary secretion	42/1189	95/7206	1.53968604685e-10
ko03040	Spliceosome	1/1189	145/7206	1.94539984354e-10
ko04925	Aldosterone synthesis and secretion	41/1189	105/7206	2.70706295773e-08
ko05203	Viral carcinogenesis	16/1189	277/7206	5.75166281239e-08
ko04022	cGMP-PKG signaling pathway	67/1189	216/7206	7.19550872974e-08
ko04360	Axon guidance	71/1189	233/7206	7.34864868783e-08
ko04971	Gastric acid secretion	37/1189	98/7206	3.11880760332e-07
ko04740	Olfactory transduction	32/1189	80/7206	4.06033220897e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1189	74/7206	6.62972042549e-07
ko03013	RNA transport	7/1189	166/7206	1.27099545658e-06
ko04070	Phosphatidylinositol signaling system	39/1189	112/7206	1.9686320086e-06
ko04966	Collecting duct acid secretion	15/1189	26/7206	2.12416654846e-06
ko05322	Systemic lupus erythematosus	6/1189	151/7206	2.22329419628e-06
ko04060	Cytokine-cytokine receptor interaction	10/1189	191/7206	2.53783344098e-06
ko04514	Cell adhesion molecules (CAMs)	42/1189	130/7206	6.9482353013e-06
ko05030	Cocaine addiction	28/1189	73/7206	7.45731255464e-06
ko05168	Herpes simplex infection	10/1189	182/7206	1.01680563445e-05
ko04924	Renin secretion	31/1189	86/7206	1.12432536742e-05
ko04972	Pancreatic secretion	37/1189	111/7206	1.28428540602e-05
ko04621	NOD-like receptor signaling pathway	8/1189	157/7206	1.74290018685e-05
ko05164	Influenza A	9/1189	167/7206	1.87765340766e-05
ko04610	Complement and coagulation cascades	1/1189	79/7206	2.06835241924e-05
ko04010	MAPK signaling pathway	82/1189	321/7206	2.84744845223e-05
ko04745	Phototransduction - fly	17/1189	38/7206	3.96409410338e-05
ko05110	Vibrio cholerae infection	24/1189	63/7206	4.09539442148e-05
ko04120	Ubiquitin mediated proteolysis	7/1189	138/7206	6.49320679351e-05
ko04141	Protein processing in endoplasmic reticulum	12/1189	184/7206	7.29713103324e-05
ko04730	Long-term depression	27/1189	78/7206	8.2475693298e-05
ko04072	Phospholipase D signaling pathway	54/1189	197/7206	8.57485399927e-05
ko04540	Gap junction	39/1189	128/7206	9.08423472491e-05
ko04110	Cell cycle	8/1189	145/7206	9.77340722514e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1189	79/7206	0.000100691056476
ko03008	Ribosome biogenesis in eukaryotes	2/1189	79/7206	0.000174375577003
ko05140	Leishmaniasis	2/1189	75/7206	0.000250298688
ko05414	Dilated cardiomyopathy	34/1189	112/7206	0.000256661576875
ko04964	Proximal tubule bicarbonate reclamation	13/1189	29/7206	0.000315664362795
ko04976	Bile secretion	26/1189	80/7206	0.000377477473361
ko04064	NF-kappa B signaling pathway	4/1189	96/7206	0.000417813537452
ko04014	Ras signaling pathway	68/1189	279/7206	0.000529643994012
ko04750	Inflammatory mediator regulation of TRP channels	35/1189	122/7206	0.000757025445703
ko04146	Peroxisome	4/1189	89/7206	0.000817779403617
ko04612	Antigen processing and presentation	3/1189	77/7206	0.00102170269055
ko04626	Plant-pathogen interaction	9/1189	18/7206	0.001032406297
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1189	59/7206	0.00110318354781
ko05205	Proteoglycans in cancer	26/1189	271/7206	0.00111169597637
ko04915	Estrogen signaling pathway	36/1189	131/7206	0.00124614160631
ko04371	Apelin signaling pathway	46/1189	177/7206	0.00134744027992
ko04260	Cardiac muscle contraction	29/1189	98/7206	0.00136112074815
ko05169	Epstein-Barr virus infection	18/1189	206/7206	0.00157289797437
ko04923	Regulation of lipolysis in adipocytes	24/1189	77/7206	0.00162853947761
ko05162	Measles	8/1189	120/7206	0.00182223274383
ko00330	Arginine and proline metabolism	2/1189	61/7206	0.00266743961526
ko04710	Circadian rhythm	15/1189	43/7206	0.00299986513049
ko05161	Hepatitis B	15/1189	173/7206	0.00354662562013
ko05144	Malaria	1/1189	45/7206	0.00439151805457
ko00071	Fatty acid degradation	1/1189	45/7206	0.00439151805457
ko03420	Nucleotide excision repair	1/1189	46/7206	0.00441086755243
ko00480	Glutathione metabolism	2/1189	55/7206	0.0056424281867
ko00562	Inositol phosphate metabolism	25/1189	89/7206	0.00572929046263
ko05321	Inflammatory bowel disease (IBD)	2/1189	56/7206	0.00575333947134
ko00240	Pyrimidine metabolism	8/1189	110/7206	0.00623494169578
ko04640	Hematopoietic cell lineage	3/1189	64/7206	0.00640612805757
ko03022	Basal transcription factors	1/1189	44/7206	0.00673623446605
ko00310	Lysine degradation	4/1189	73/7206	0.00679182209432
ko05131	Shigellosis	5/1189	82/7206	0.00689620332377
ko00590	Arachidonic acid metabolism	2/1189	52/7206	0.0082558009787
ko04622	RIG-I-like receptor signaling pathway	3/1189	62/7206	0.00918752914769
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1189	40/7206	0.00988993093357
ko00140	Steroid hormone biosynthesis	1/1189	41/7206	0.00994206521808
ko04922	Glucagon signaling pathway	32/1189	128/7206	0.0115700612697
ko04916	Melanogenesis	35/1189	142/7206	0.0116060925944
ko04711	Circadian rhythm - fly	6/1189	13/7206	0.011983536686
ko00380	Tryptophan metabolism	2/1189	50/7206	0.0120297209107
ko04657	IL-17 signaling pathway	6/1189	87/7206	0.0127827297648
ko05133	Pertussis	6/1189	87/7206	0.0127827297648
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1189	100/7206	0.0140715565613
ko04210	Apoptosis	18/1189	180/7206	0.0146349396008
ko03410	Base excision repair	1/1189	38/7206	0.0147813196452
ko05145	Toxoplasmosis	11/1189	126/7206	0.0151639904838
ko03018	RNA degradation	6/1189	84/7206	0.0173507826405
ko00260	Glycine, serine and threonine metabolism	2/1189	48/7206	0.0176290785161
ko05219	Bladder cancer	2/1189	48/7206	0.0176290785161
ko04630	Jak-STAT signaling pathway	12/1189	132/7206	0.0177724712221
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1189	14/7206	0.0180925183499
ko04918	Thyroid hormone synthesis	23/1189	86/7206	0.0181004512343
ko04115	p53 signaling pathway	5/1189	74/7206	0.0182418280821
ko04217	Necroptosis	18/1189	178/7206	0.0184291040595
ko04912	GnRH signaling pathway	30/1189	122/7206	0.0191508287301
ko00982	Drug metabolism - cytochrome P450	1/1189	37/7206	0.0231542603092
ko05166	HTLV-I infection	34/1189	292/7206	0.0238632663674
ko04214	Apoptosis - fly	5/1189	72/7206	0.0249542834412
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1189	182/7206	0.0256241996123
ko00280	Valine, leucine and isoleucine degradation	3/1189	54/7206	0.0263170449024
ko04658	Th1 and Th2 cell differentiation	8/1189	96/7206	0.0266748533621
ko04270	Vascular smooth muscle contraction	36/1189	154/7206	0.0274230435588
ko04114	Oocyte meiosis	33/1189	139/7206	0.027535455233
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1189	92/7206	0.0333650533128
ko03320	PPAR signaling pathway	5/1189	69/7206	0.0340706537712
ko04930	Type II diabetes mellitus	15/1189	54/7206	0.0401095327575
ko04620	Toll-like receptor signaling pathway	9/1189	100/7206	0.0414619737475
ko04510	Focal adhesion	28/1189	240/7206	0.0416068709631
ko01524	Platinum drug resistance	6/1189	76/7206	0.0426262414754
ko05231	Choline metabolism in cancer	31/1189	134/7206	0.0450005806109
ko05202	Transcriptional misregulation in cancer	21/1189	188/7206	0.0463082862454
ko05340	Primary immunodeficiency	1/1189	30/7206	0.0489735727819