ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	208/1297	423/7206	5.0711983014e-52
ko04724	Glutamatergic synapse	90/1297	152/7206	2.1201919291e-30
ko05033	Nicotine addiction	47/1297	56/7206	6.94868761714e-27
ko04713	Circadian entrainment	78/1297	136/7206	3.3825381185e-25
ko05032	Morphine addiction	68/1297	110/7206	9.50937583434e-25
ko04727	GABAergic synapse	65/1297	110/7206	3.70003761214e-22
ko04728	Dopaminergic synapse	87/1297	185/7206	3.91987859315e-20
ko04020	Calcium signaling pathway	110/1297	265/7206	8.01258688004e-20
ko04725	Cholinergic synapse	78/1297	160/7206	2.46150044022e-19
ko04723	Retrograde endocannabinoid signaling	79/1297	175/7206	4.50457236917e-17
ko04721	Synaptic vesicle cycle	48/1297	80/7206	4.690466889e-17
ko04024	cAMP signaling pathway	107/1297	279/7206	2.47583946566e-16
ko04911	Insulin secretion	58/1297	117/7206	4.27240571424e-15
ko04726	Serotonergic synapse	62/1297	137/7206	1.02504329764e-13
ko04742	Taste transduction	37/1297	61/7206	1.19503677457e-13
ko04921	Oxytocin signaling pathway	81/1297	209/7206	7.14487700203e-13
ko04970	Salivary secretion	45/1297	95/7206	3.87328659506e-11
ko05031	Amphetamine addiction	43/1297	91/7206	1.16832582524e-10
ko03040	Spliceosome	2/1297	145/7206	2.21920768187e-10
ko03010	Ribosome	1/1297	129/7206	3.41306640455e-10
ko04720	Long-term potentiation	44/1297	99/7206	8.43474898954e-10
ko04261	Adrenergic signaling in cardiomyocytes	73/1297	205/7206	1.48923264253e-09
ko05322	Systemic lupus erythematosus	4/1297	151/7206	6.00092244959e-09
ko04925	Aldosterone synthesis and secretion	43/1297	105/7206	4.51454468512e-08
ko04744	Phototransduction	21/1297	36/7206	6.9307514613e-08
ko04971	Gastric acid secretion	40/1297	98/7206	9.40913193738e-08
ko04022	cGMP-PKG signaling pathway	71/1297	216/7206	1.1192138845e-07
ko05203	Viral carcinogenesis	20/1297	277/7206	2.42676168748e-07
ko03013	RNA transport	8/1297	166/7206	5.87288632101e-07
ko04360	Axon guidance	72/1297	233/7206	1.3610689849e-06
ko05168	Herpes simplex infection	11/1297	182/7206	3.19213849266e-06
ko04972	Pancreatic secretion	40/1297	111/7206	4.75974570762e-06
ko04730	Long-term depression	31/1297	78/7206	8.12448161271e-06
ko04070	Phosphatidylinositol signaling system	40/1297	112/7206	8.70075732232e-06
ko05030	Cocaine addiction	29/1297	73/7206	1.05308471955e-05
ko05164	Influenza A	11/1297	167/7206	2.3998833611e-05
ko04740	Olfactory transduction	30/1297	80/7206	2.91476581124e-05
ko04976	Bile secretion	30/1297	80/7206	2.91476581124e-05
ko04072	Phospholipase D signaling pathway	59/1297	197/7206	3.03142878808e-05
ko04745	Phototransduction - fly	18/1297	38/7206	3.04203937107e-05
ko04014	Ras signaling pathway	78/1297	279/7206	3.11203220576e-05
ko04966	Collecting duct acid secretion	14/1297	26/7206	3.88028379535e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1297	79/7206	4.44693439189e-05
ko04110	Cell cycle	9/1297	145/7206	4.47537105769e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1297	74/7206	4.78283977144e-05
ko04924	Renin secretion	31/1297	86/7206	5.57512044649e-05
ko04270	Vascular smooth muscle contraction	48/1297	154/7206	6.96049755051e-05
ko04010	MAPK signaling pathway	86/1297	321/7206	7.37340128027e-05
ko04141	Protein processing in endoplasmic reticulum	14/1297	184/7206	8.45054724836e-05
ko04621	NOD-like receptor signaling pathway	11/1297	157/7206	8.88339362662e-05
ko04540	Gap junction	41/1297	128/7206	0.000103511536867
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1297	79/7206	0.000180492483018
ko04060	Cytokine-cytokine receptor interaction	16/1297	191/7206	0.000182317627201
ko04514	Cell adhesion molecules (CAMs)	41/1297	130/7206	0.000183162639282
ko04710	Circadian rhythm	18/1297	43/7206	0.000221749768697
ko00520	Amino sugar and nucleotide sugar metabolism	1/1297	55/7206	0.000332806117964
ko05110	Vibrio cholerae infection	23/1297	63/7206	0.000414759925981
ko05169	Epstein-Barr virus infection	19/1297	206/7206	0.0004465842418
ko04750	Inflammatory mediator regulation of TRP channels	38/1297	122/7206	0.000475363512644
ko05414	Dilated cardiomyopathy	35/1297	112/7206	0.000686274949029
ko04371	Apelin signaling pathway	50/1297	177/7206	0.000688905969187
ko04120	Ubiquitin mediated proteolysis	11/1297	138/7206	0.00108264564142
ko05161	Hepatitis B	16/1297	173/7206	0.00176306559887
ko03420	Nucleotide excision repair	1/1297	46/7206	0.00177150356609
ko04922	Glucagon signaling pathway	37/1297	128/7206	0.00232166030463
ko03022	Basal transcription factors	1/1297	44/7206	0.00267876624639
ko04964	Proximal tubule bicarbonate reclamation	12/1297	29/7206	0.00277768827971
ko05162	Measles	10/1297	120/7206	0.00380014644155
ko04915	Estrogen signaling pathway	37/1297	131/7206	0.00380786019738
ko04622	RIG-I-like receptor signaling pathway	3/1297	62/7206	0.00416953634675
ko04923	Regulation of lipolysis in adipocytes	24/1297	77/7206	0.00430658644046
ko04064	NF-kappa B signaling pathway	7/1297	96/7206	0.00452763167857
ko04657	IL-17 signaling pathway	6/1297	87/7206	0.00458784545319
ko05133	Pertussis	6/1297	87/7206	0.00458784545319
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1297	100/7206	0.00579176142206
ko04612	Antigen processing and presentation	5/1297	77/7206	0.00655557783869
ko04930	Type II diabetes mellitus	18/1297	54/7206	0.00660183202959
ko04916	Melanogenesis	38/1297	142/7206	0.00801939334744
ko04626	Plant-pathogen interaction	8/1297	18/7206	0.00853840150226
ko05131	Shigellosis	6/1297	82/7206	0.00874297434826
ko00310	Lysine degradation	5/1297	73/7206	0.00896372424442
ko05140	Leishmaniasis	5/1297	75/7206	0.00927212467025
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1297	59/7206	0.00940376456348
ko03410	Base excision repair	1/1297	38/7206	0.00943009384746
ko04217	Necroptosis	19/1297	178/7206	0.00983393437015
ko04260	Cardiac muscle contraction	28/1297	98/7206	0.0110933614314
ko04610	Complement and coagulation cascades	6/1297	79/7206	0.0119896563776
ko04912	GnRH signaling pathway	33/1297	122/7206	0.0121417095387
ko00280	Valine, leucine and isoleucine degradation	3/1297	54/7206	0.0123105882613
ko05166	HTLV-I infection	37/1297	292/7206	0.0156727451094
ko05144	Malaria	2/1297	45/7206	0.0173171073759
ko00071	Fatty acid degradation	2/1297	45/7206	0.0173171073759
ko04142	Lysosome	16/1297	151/7206	0.0179007535232
ko04711	Circadian rhythm - fly	6/1297	13/7206	0.0182383457496
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1297	182/7206	0.0190367089148
ko03018	RNA degradation	7/1297	84/7206	0.0211225153542
ko04115	p53 signaling pathway	6/1297	74/7206	0.0223401905177
ko04658	Th1 and Th2 cell differentiation	9/1297	96/7206	0.0230934021097
ko05145	Toxoplasmosis	13/1297	126/7206	0.025415919721
ko04146	Peroxisome	8/1297	89/7206	0.0255027552421
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1297	14/7206	0.0271510600544
ko04630	Jak-STAT signaling pathway	14/1297	132/7206	0.0289562937301
ko05205	Proteoglycans in cancer	35/1297	271/7206	0.0291499596603
ko04214	Apoptosis - fly	6/1297	72/7206	0.0302809557742
ko05231	Choline metabolism in cancer	34/1297	134/7206	0.0305393521071
ko04015	Rap1 signaling pathway	64/1297	278/7206	0.0312695932809
ko05416	Viral myocarditis	4/1297	55/7206	0.0344243289373
ko04620	Toll-like receptor signaling pathway	10/1297	100/7206	0.0355281910658
ko05219	Bladder cancer	3/1297	48/7206	0.035975508134
ko04960	Aldosterone-regulated sodium reabsorption	13/1297	41/7206	0.0380653849609
ko04210	Apoptosis	22/1297	180/7206	0.0392552647937
ko03015	mRNA surveillance pathway	9/1297	93/7206	0.0402925541089
ko04113	Meiosis - yeast	6/1297	70/7206	0.0409823320115
ko04973	Carbohydrate digestion and absorption	13/1297	42/7206	0.04115763331
ko05202	Transcriptional misregulation in cancer	23/1297	188/7206	0.0427085901199
ko05215	Prostate cancer	12/1297	111/7206	0.0463559749406