ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	134/735	423/7206	1.30346551053e-36
ko04724	Glutamatergic synapse	74/735	152/7206	2.67352367844e-34
ko05033	Nicotine addiction	43/735	56/7206	3.94576834466e-32
ko05032	Morphine addiction	53/735	110/7206	1.68775853688e-24
ko04727	GABAergic synapse	50/735	110/7206	9.66733787243e-22
ko04723	Retrograde endocannabinoid signaling	64/735	175/7206	2.7331385944e-21
ko04728	Dopaminergic synapse	64/735	185/7206	8.16196216161e-20
ko04713	Circadian entrainment	53/735	136/7206	3.04895079385e-19
ko04024	cAMP signaling pathway	77/735	279/7206	4.6693008154e-17
ko04725	Cholinergic synapse	54/735	160/7206	2.46412406621e-16
ko04721	Synaptic vesicle cycle	35/735	80/7206	6.18437471368e-15
ko04911	Insulin secretion	40/735	117/7206	1.3003549223e-12
ko04742	Taste transduction	27/735	61/7206	5.83915030163e-12
ko04020	Calcium signaling pathway	65/735	265/7206	6.1225166354e-12
ko04261	Adrenergic signaling in cardiomyocytes	54/735	205/7206	2.15692416701e-11
ko04921	Oxytocin signaling pathway	54/735	209/7206	4.83646029587e-11
ko04726	Serotonergic synapse	40/735	137/7206	3.35977972244e-10
ko05031	Amphetamine addiction	30/735	91/7206	2.38765041879e-09
ko04720	Long-term potentiation	31/735	99/7206	5.31107726598e-09
ko04970	Salivary secretion	30/735	95/7206	7.52913254106e-09
ko05030	Cocaine addiction	25/735	73/7206	2.18364618663e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	24/735	74/7206	1.36985175529e-07
ko04010	MAPK signaling pathway	63/735	321/7206	2.18074875046e-07
ko04744	Phototransduction	15/735	36/7206	8.3636917297e-07
ko04260	Cardiac muscle contraction	26/735	98/7206	3.24282811846e-06
ko04971	Gastric acid secretion	26/735	98/7206	3.24282811846e-06
ko04072	Phospholipase D signaling pathway	42/735	197/7206	3.30497106818e-06
ko05203	Viral carcinogenesis	8/735	277/7206	3.97470773429e-06
ko04972	Pancreatic secretion	28/735	111/7206	4.02071428686e-06
ko03040	Spliceosome	1/735	145/7206	4.8393864891e-06
ko04514	Cell adhesion molecules (CAMs)	31/735	130/7206	5.16546075859e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	22/735	79/7206	7.88035897674e-06
ko04925	Aldosterone synthesis and secretion	26/735	105/7206	1.26959571346e-05
ko04730	Long-term depression	21/735	78/7206	2.22780750441e-05
ko04022	cGMP-PKG signaling pathway	42/735	216/7206	3.08363440362e-05
ko05164	Influenza A	3/735	167/7206	4.10774430281e-05
ko05168	Herpes simplex infection	4/735	182/7206	5.18925505039e-05
ko04060	Cytokine-cytokine receptor interaction	5/735	191/7206	8.54387363084e-05
ko04915	Estrogen signaling pathway	28/735	131/7206	0.000116001761417
ko05322	Systemic lupus erythematosus	3/735	151/7206	0.000178953694857
ko05414	Dilated cardiomyopathy	25/735	112/7206	0.000191738828281
ko04540	Gap junction	27/735	128/7206	0.000290285573535
ko05205	Proteoglycans in cancer	11/735	271/7206	0.00029554238226
ko04740	Olfactory transduction	19/735	80/7206	0.000503272203805
ko04120	Ubiquitin mediated proteolysis	3/735	138/7206	0.000516213215827
ko03013	RNA transport	5/735	166/7206	0.000663044551403
ko05169	Epstein-Barr virus infection	8/735	206/7206	0.00100833012443
ko04621	NOD-like receptor signaling pathway	5/735	157/7206	0.00186467213086
ko04141	Protein processing in endoplasmic reticulum	7/735	184/7206	0.0018730734724
ko04070	Phosphatidylinositol signaling system	22/735	112/7206	0.00234641828598
ko04924	Renin secretion	18/735	86/7206	0.0032215560554
ko04745	Phototransduction - fly	10/735	38/7206	0.00382107991494
ko04360	Axon guidance	38/735	233/7206	0.00390917196225
ko04612	Antigen processing and presentation	1/735	77/7206	0.00397419176734
ko03008	Ribosome biogenesis in eukaryotes	1/735	79/7206	0.00410177922523
ko05410	Hypertrophic cardiomyopathy (HCM)	19/735	100/7206	0.00688140975949
ko04964	Proximal tubule bicarbonate reclamation	8/735	29/7206	0.00691505985062
ko04961	Endocrine and other factor-regulated calcium reabsorption	13/735	59/7206	0.00728034852899
ko04350	TGF-beta signaling pathway	3/735	103/7206	0.00834164180895
ko04014	Ras signaling pathway	42/735	279/7206	0.00857624470226
ko04550	Signaling pathways regulating pluripotency of stem cells	7/735	165/7206	0.00859172227741
ko05162	Measles	4/735	120/7206	0.00889195861938
ko04214	Apoptosis - fly	1/735	72/7206	0.00913047080582
ko04750	Inflammatory mediator regulation of TRP channels	22/735	122/7206	0.0092636670716
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/735	14/7206	0.00995238457083
ko04930	Type II diabetes mellitus	12/735	54/7206	0.010018723821
ko05161	Hepatitis B	8/735	173/7206	0.0106476048173
ko04071	Sphingolipid signaling pathway	27/735	162/7206	0.0117290996475
ko04110	Cell cycle	6/735	145/7206	0.0118722839935
ko04630	Jak-STAT signaling pathway	5/735	132/7206	0.0125159298102
ko04966	Collecting duct acid secretion	7/735	26/7206	0.0130001990277
ko04150	mTOR signaling pathway	9/735	184/7206	0.0131063138994
ko04064	NF-kappa B signaling pathway	3/735	96/7206	0.0164329124384
ko00240	Pyrimidine metabolism	4/735	110/7206	0.0167079160552
ko05215	Prostate cancer	4/735	111/7206	0.0167838789536
ko04217	Necroptosis	9/735	178/7206	0.0171414135867
ko04932	Non-alcoholic fatty liver disease (NAFLD)	9/735	182/7206	0.0175127135843
ko04640	Hematopoietic cell lineage	1/735	64/7206	0.0195221524349
ko00562	Inositol phosphate metabolism	16/735	89/7206	0.0210192000594
ko00310	Lysine degradation	2/735	73/7206	0.0307705153681
ko04918	Thyroid hormone synthesis	15/735	86/7206	0.0315330343336
ko05140	Leishmaniasis	2/735	75/7206	0.0318801923411
ko04146	Peroxisome	3/735	89/7206	0.0322827116024
ko05110	Vibrio cholerae infection	12/735	63/7206	0.0327358202415
ko05166	HTLV-I infection	19/735	292/7206	0.0374009612602
ko05034	Alcoholism	34/735	238/7206	0.0384178886289
ko00480	Glutathione metabolism	1/735	55/7206	0.0403340771197
ko05231	Choline metabolism in cancer	21/735	134/7206	0.0426255554213
ko04218	Cellular senescence	10/735	177/7206	0.0434560830066
ko04137	Mitophagy - animal	3/735	82/7206	0.0438797939837
ko03018	RNA degradation	3/735	84/7206	0.0441575598214
ko04140	Autophagy - animal	9/735	164/7206	0.0488506164505