ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 154/926 423/7206 9.52559289098e-38 ko04724 Glutamatergic synapse 78/926 152/7206 5.47144941048e-31 ko05033 Nicotine addiction 44/926 56/7206 2.99700917117e-29 ko05032 Morphine addiction 57/926 110/7206 3.68833035441e-23 ko04728 Dopaminergic synapse 76/926 185/7206 1.95478592205e-22 ko04727 GABAergic synapse 56/926 110/7206 2.80198816531e-22 ko04713 Circadian entrainment 61/926 136/7206 1.56040526559e-20 ko04723 Retrograde endocannabinoid signaling 70/926 175/7206 5.92667218255e-20 ko04020 Calcium signaling pathway 83/926 265/7206 9.14935312756e-16 ko04725 Cholinergic synapse 60/926 160/7206 1.08847648405e-15 ko04721 Synaptic vesicle cycle 39/926 80/7206 4.66664126514e-15 ko04024 cAMP signaling pathway 84/926 279/7206 7.80181743243e-15 ko04726 Serotonergic synapse 52/926 137/7206 5.28947090245e-14 ko04911 Insulin secretion 47/926 117/7206 7.45816519803e-14 ko04921 Oxytocin signaling pathway 63/926 209/7206 2.63063241256e-11 ko04742 Taste transduction 29/926 61/7206 3.47551503928e-11 ko05031 Amphetamine addiction 36/926 91/7206 1.0971348559e-10 ko04744 Phototransduction 21/926 36/7206 1.29700832291e-10 ko04261 Adrenergic signaling in cardiomyocytes 60/926 205/7206 2.37317018665e-10 ko04720 Long-term potentiation 37/926 99/7206 4.1630234707e-10 ko03040 Spliceosome 1/926 145/7206 9.62339320974e-08 ko04925 Aldosterone synthesis and secretion 34/926 105/7206 1.36351029891e-07 ko05030 Cocaine addiction 26/926 73/7206 5.1233287258e-07 ko05203 Viral carcinogenesis 11/926 277/7206 5.31844514731e-07 ko03010 Ribosome 1/926 129/7206 7.41702838405e-07 ko04970 Salivary secretion 30/926 95/7206 1.3530645664e-06 ko03013 RNA transport 4/926 166/7206 3.02580377606e-06 ko04971 Gastric acid secretion 30/926 98/7206 4.06385481382e-06 ko04745 Phototransduction - fly 16/926 38/7206 6.82121346943e-06 ko04070 Phosphatidylinositol signaling system 32/926 112/7206 9.96922163229e-06 ko04514 Cell adhesion molecules (CAMs) 35/926 130/7206 1.39263891713e-05 ko05322 Systemic lupus erythematosus 4/926 151/7206 1.99859863745e-05 ko04060 Cytokine-cytokine receptor interaction 7/926 191/7206 2.31132047903e-05 ko04730 Long-term depression 24/926 78/7206 2.49144314915e-05 ko04972 Pancreatic secretion 30/926 111/7206 4.59641368967e-05 ko04072 Phospholipase D signaling pathway 46/926 197/7206 5.03077749696e-05 ko05164 Influenza A 6/926 167/7206 5.65166464121e-05 ko04010 MAPK signaling pathway 66/926 321/7206 7.61593069407e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 22/926 74/7206 0.000131727885708 ko04740 Olfactory transduction 23/926 80/7206 0.000133847298466 ko04110 Cell cycle 5/926 145/7206 0.000142324369045 ko04621 NOD-like receptor signaling pathway 6/926 157/7206 0.000158603438514 ko05168 Herpes simplex infection 8/926 182/7206 0.000179304635763 ko05169 Epstein-Barr virus infection 10/926 206/7206 0.00018517899275 ko04022 cGMP-PKG signaling pathway 47/926 216/7206 0.000258391692462 ko04750 Inflammatory mediator regulation of TRP channels 30/926 122/7206 0.000323455856113 ko04360 Axon guidance 49/926 233/7206 0.000437108469566 ko04612 Antigen processing and presentation 1/926 77/7206 0.000478423060373 ko04964 Proximal tubule bicarbonate reclamation 11/926 29/7206 0.000566774402582 ko04260 Cardiac muscle contraction 25/926 98/7206 0.000630583574827 ko04710 Circadian rhythm 14/926 43/7206 0.000643431400071 ko04141 Protein processing in endoplasmic reticulum 10/926 184/7206 0.001136748707 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 20/926 79/7206 0.00210401426933 ko04930 Type II diabetes mellitus 15/926 54/7206 0.00313909366131 ko05161 Hepatitis B 10/926 173/7206 0.00372201626267 ko04966 Collecting duct acid secretion 9/926 26/7206 0.0037251376275 ko04540 Gap junction 28/926 128/7206 0.00460548588634 ko05140 Leishmaniasis 2/926 75/7206 0.00470114999131 ko04915 Estrogen signaling pathway 28/926 131/7206 0.00539476422423 ko04630 Jak-STAT signaling pathway 7/926 132/7206 0.0056633603771 ko05200 Pathways in cancer 44/926 492/7206 0.00639336989191 ko04922 Glucagon signaling pathway 27/926 128/7206 0.00747534716763 ko04014 Ras signaling pathway 51/926 279/7206 0.00794698349227 ko04064 NF-kappa B signaling pathway 4/926 96/7206 0.00814690043426 ko05162 Measles 6/926 120/7206 0.00819547221895 ko04924 Renin secretion 20/926 86/7206 0.00833723567911 ko05231 Choline metabolism in cancer 28/926 134/7206 0.00853715680084 ko04120 Ubiquitin mediated proteolysis 8/926 138/7206 0.00974037927228 ko05414 Dilated cardiomyopathy 24/926 112/7206 0.00986575161685 ko04610 Complement and coagulation cascades 3/926 79/7206 0.0106302918535 ko05110 Vibrio cholerae infection 15/926 63/7206 0.0136805884754 ko04657 IL-17 signaling pathway 4/926 87/7206 0.0153188400109 ko05133 Pertussis 4/926 87/7206 0.0153188400109 ko05166 HTLV-I infection 24/926 292/7206 0.0155625667163 ko04146 Peroxisome 4/926 89/7206 0.0155705050799 ko04960 Aldosterone-regulated sodium reabsorption 11/926 41/7206 0.0156413694039 ko04973 Carbohydrate digestion and absorption 11/926 42/7206 0.01764338184 ko04711 Circadian rhythm - fly 5/926 13/7206 0.0183448293672 ko04658 Th1 and Th2 cell differentiation 5/926 96/7206 0.0206016564643 ko04626 Plant-pathogen interaction 6/926 18/7206 0.0209322574917 ko05410 Hypertrophic cardiomyopathy (HCM) 21/926 100/7206 0.0225112547332 ko00562 Inositol phosphate metabolism 19/926 89/7206 0.0240976586746 ko05144 Malaria 1/926 45/7206 0.0248992144787 ko00071 Fatty acid degradation 1/926 45/7206 0.0248992144787 ko03420 Nucleotide excision repair 1/926 46/7206 0.0250486303401 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/926 14/7206 0.0255821478832 ko04932 Non-alcoholic fatty liver disease (NAFLD) 14/926 182/7206 0.0329136169662 ko04620 Toll-like receptor signaling pathway 6/926 100/7206 0.0352057620629 ko03022 Basal transcription factors 1/926 44/7206 0.0379867679328 ko05416 Viral myocarditis 2/926 55/7206 0.0408239802545 ko05321 Inflammatory bowel disease (IBD) 2/926 56/7206 0.0417353652146 ko05202 Transcriptional misregulation in cancer 15/926 188/7206 0.0460788399489 ko05132 Salmonella infection 6/926 98/7206 0.0469844305978 ko04961 Endocrine and other factor-regulated calcium reabsorption 13/926 59/7206 0.0477212622546