ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	193/1104	423/7206	1.96261696286e-53
ko04724	Glutamatergic synapse	88/1104	152/7206	3.08311752296e-34
ko05033	Nicotine addiction	48/1104	56/7206	1.32154687797e-31
ko05032	Morphine addiction	65/1104	110/7206	3.24517498504e-26
ko04727	GABAergic synapse	64/1104	110/7206	2.68441666195e-25
ko04713	Circadian entrainment	71/1104	136/7206	4.56071623458e-24
ko04728	Dopaminergic synapse	84/1104	185/7206	5.65468250835e-23
ko04721	Synaptic vesicle cycle	51/1104	80/7206	5.87269592178e-23
ko04725	Cholinergic synapse	75/1104	160/7206	1.19496928434e-21
ko04723	Retrograde endocannabinoid signaling	76/1104	175/7206	1.87903190045e-19
ko04024	cAMP signaling pathway	102/1104	279/7206	6.07660554864e-19
ko04020	Calcium signaling pathway	94/1104	265/7206	1.63116954473e-16
ko04911	Insulin secretion	54/1104	117/7206	1.54202754758e-15
ko04921	Oxytocin signaling pathway	78/1104	209/7206	2.73785118024e-15
ko04742	Taste transduction	36/1104	61/7206	5.03194963469e-15
ko04726	Serotonergic synapse	56/1104	137/7206	2.81585820753e-13
ko04261	Adrenergic signaling in cardiomyocytes	73/1104	205/7206	3.38430195157e-13
ko04744	Phototransduction	24/1104	36/7206	4.36111043522e-12
ko04720	Long-term potentiation	43/1104	99/7206	1.55457542074e-11
ko05031	Amphetamine addiction	40/1104	91/7206	5.10946921894e-11
ko04970	Salivary secretion	40/1104	95/7206	2.54967901903e-10
ko03040	Spliceosome	1/1104	145/7206	1.36253791729e-09
ko05203	Viral carcinogenesis	13/1104	277/7206	2.05983658993e-08
ko04740	Olfactory transduction	32/1104	80/7206	6.97066256633e-08
ko04925	Aldosterone synthesis and secretion	38/1104	105/7206	1.23180852174e-07
ko04360	Axon guidance	67/1104	233/7206	1.35085936547e-07
ko04022	cGMP-PKG signaling pathway	63/1104	216/7206	1.38623609564e-07
ko05168	Herpes simplex infection	6/1104	182/7206	1.88847612264e-07
ko05030	Cocaine addiction	29/1104	73/7206	3.41060770979e-07
ko04060	Cytokine-cytokine receptor interaction	7/1104	191/7206	3.54690502794e-07
ko04971	Gastric acid secretion	35/1104	98/7206	5.38329646013e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1104	74/7206	1.73857427555e-06
ko05322	Systemic lupus erythematosus	5/1104	151/7206	3.07533229204e-06
ko03013	RNA transport	7/1104	166/7206	9.06957270989e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1104	79/7206	9.49771484094e-06
ko04010	MAPK signaling pathway	78/1104	321/7206	1.62640499014e-05
ko04070	Phosphatidylinositol signaling system	35/1104	112/7206	1.65802712587e-05
ko04072	Phospholipase D signaling pathway	53/1104	197/7206	2.05177907219e-05
ko05164	Influenza A	8/1104	167/7206	2.7812090596e-05
ko04966	Collecting duct acid secretion	13/1104	26/7206	3.52205099664e-05
ko04141	Protein processing in endoplasmic reticulum	10/1104	184/7206	4.24305695631e-05
ko04972	Pancreatic secretion	34/1104	111/7206	4.48068812753e-05
ko04260	Cardiac muscle contraction	31/1104	98/7206	4.82288912229e-05
ko05414	Dilated cardiomyopathy	34/1104	112/7206	5.02583731612e-05
ko04745	Phototransduction - fly	16/1104	38/7206	6.48672808749e-05
ko04730	Long-term depression	26/1104	78/7206	8.76927230858e-05
ko04110	Cell cycle	7/1104	145/7206	0.000100797545107
ko04514	Cell adhesion molecules (CAMs)	37/1104	130/7206	0.000109266797255
ko04621	NOD-like receptor signaling pathway	8/1104	157/7206	0.000111055674969
ko04540	Gap junction	36/1104	128/7206	0.000168896054095
ko04064	NF-kappa B signaling pathway	3/1104	96/7206	0.000169807882074
ko05169	Epstein-Barr virus infection	14/1104	206/7206	0.00025059920616
ko04120	Ubiquitin mediated proteolysis	7/1104	138/7206	0.000283332903357
ko05110	Vibrio cholerae infection	21/1104	63/7206	0.000306398399986
ko04915	Estrogen signaling pathway	36/1104	131/7206	0.000316113486153
ko05205	Proteoglycans in cancer	22/1104	271/7206	0.000402450742191
ko04924	Renin secretion	26/1104	86/7206	0.00040863972657
ko04610	Complement and coagulation cascades	2/1104	79/7206	0.000410869078094
ko03008	Ribosome biogenesis in eukaryotes	2/1104	79/7206	0.000410869078094
ko04626	Plant-pathogen interaction	9/1104	18/7206	0.000589602248189
ko05140	Leishmaniasis	2/1104	75/7206	0.000599150772444
ko04612	Antigen processing and presentation	2/1104	77/7206	0.000623660000814
ko04014	Ras signaling pathway	63/1104	279/7206	0.00119570859111
ko05161	Hepatitis B	12/1104	173/7206	0.00122065666336
ko04371	Apelin signaling pathway	43/1104	177/7206	0.00144329444139
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1104	59/7206	0.00149072578594
ko05162	Measles	7/1104	120/7206	0.00197969904733
ko00480	Glutathione metabolism	1/1104	55/7206	0.00209089454913
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1104	14/7206	0.00247644560233
ko04976	Bile secretion	23/1104	80/7206	0.00249422694748
ko04146	Peroxisome	4/1104	89/7206	0.00262214691739
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1104	100/7206	0.00288286903279
ko00590	Arachidonic acid metabolism	1/1104	52/7206	0.00311291960289
ko04923	Regulation of lipolysis in adipocytes	22/1104	77/7206	0.00352738143819
ko04330	Notch signaling pathway	2/1104	62/7206	0.00408936570559
ko04350	TGF-beta signaling pathway	6/1104	103/7206	0.0053103080561
ko03420	Nucleotide excision repair	1/1104	46/7206	0.00694321753596
ko00240	Pyrimidine metabolism	7/1104	110/7206	0.00703407927219
ko04750	Inflammatory mediator regulation of TRP channels	30/1104	122/7206	0.00722349736795
ko00260	Glycine, serine and threonine metabolism	1/1104	48/7206	0.00734085016288
ko05166	HTLV-I infection	29/1104	292/7206	0.00780476505548
ko04964	Proximal tubule bicarbonate reclamation	10/1104	29/7206	0.00848577076891
ko05321	Inflammatory bowel disease (IBD)	2/1104	56/7206	0.00868437748877
ko01524	Platinum drug resistance	4/1104	76/7206	0.0100265578425
ko03022	Basal transcription factors	1/1104	44/7206	0.0104216188982
ko05144	Malaria	1/1104	45/7206	0.0107716714171
ko00071	Fatty acid degradation	1/1104	45/7206	0.0107716714171
ko00562	Inositol phosphate metabolism	23/1104	89/7206	0.010782662346
ko03018	RNA degradation	5/1104	84/7206	0.0139050165329
ko00310	Lysine degradation	4/1104	73/7206	0.0140145498738
ko04115	p53 signaling pathway	4/1104	74/7206	0.0140626918411
ko04912	GnRH signaling pathway	29/1104	122/7206	0.0151424685803
ko00140	Steroid hormone biosynthesis	1/1104	41/7206	0.0154698022886
ko05145	Toxoplasmosis	10/1104	126/7206	0.0174349727215
ko04510	Focal adhesion	24/1104	240/7206	0.0177326100512
ko05131	Shigellosis	5/1104	82/7206	0.0193817365058
ko00330	Arginine and proline metabolism	3/1104	61/7206	0.0193920856411
ko04622	RIG-I-like receptor signaling pathway	3/1104	62/7206	0.0196991329473
ko04214	Apoptosis - fly	4/1104	72/7206	0.0198512846287
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1104	182/7206	0.021569386176
ko04550	Signaling pathways regulating pluripotency of stem cells	15/1104	165/7206	0.0216363140677
ko00630	Glyoxylate and dicarboxylate metabolism	1/1104	38/7206	0.0229791559775
ko03410	Base excision repair	1/1104	38/7206	0.0229791559775
ko04270	Vascular smooth muscle contraction	34/1104	154/7206	0.0233004429157
ko05202	Transcriptional misregulation in cancer	18/1104	188/7206	0.0239848307516
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1104	40/7206	0.0243119599087
ko04657	IL-17 signaling pathway	6/1104	87/7206	0.0244151937994
ko05133	Pertussis	6/1104	87/7206	0.0244151937994
ko05222	Small cell lung cancer	6/1104	89/7206	0.0249394996153
ko04922	Glucagon signaling pathway	29/1104	128/7206	0.0253291368391
ko04015	Rap1 signaling pathway	56/1104	278/7206	0.0269876109304
ko04630	Jak-STAT signaling pathway	11/1104	132/7206	0.027136237728
ko04210	Apoptosis	17/1104	180/7206	0.0271834410518
ko05034	Alcoholism	49/1104	238/7206	0.0275906321484
ko04973	Carbohydrate digestion and absorption	12/1104	42/7206	0.0282898345027
ko05231	Choline metabolism in cancer	30/1104	134/7206	0.0285460578448
ko04658	Th1 and Th2 cell differentiation	7/1104	96/7206	0.0309324700239
ko04114	Oocyte meiosis	31/1104	139/7206	0.0313010745552
ko05206	MicroRNAs in cancer	17/1104	177/7206	0.0339676671846
ko00982	Drug metabolism - cytochrome P450	1/1104	37/7206	0.0355146044748
ko04930	Type II diabetes mellitus	14/1104	54/7206	0.0366843200868
ko05418	Fluid shear stress and atherosclerosis	17/1104	173/7206	0.0421163634624
ko04722	Neurotrophin signaling pathway	34/1104	160/7206	0.0448125506326
ko04062	Chemokine signaling pathway	41/1104	201/7206	0.0469024159522
ko04140	Autophagy - animal	16/1104	164/7206	0.0478069061237
ko04918	Thyroid hormone synthesis	20/1104	86/7206	0.0490470579247