ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 36/389 134/7206 2.13244441113e-16 ko04060 Cytokine-cytokine receptor interaction 41/389 191/7206 8.2968495898e-15 ko04621 NOD-like receptor signaling pathway 36/389 157/7206 4.67118067804e-14 ko04668 TNF signaling pathway 31/389 120/7206 9.23575989366e-14 ko05164 Influenza A 36/389 167/7206 3.48166267165e-13 ko05140 Leishmaniasis 24/389 75/7206 3.78736781946e-13 ko04064 NF-kappa B signaling pathway 26/389 96/7206 3.01437256363e-12 ko04620 Toll-like receptor signaling pathway 25/389 100/7206 5.4500583097e-11 ko05161 Hepatitis B 33/389 173/7206 1.17319005376e-10 ko05162 Measles 27/389 120/7206 1.25059975422e-10 ko05152 Tuberculosis 34/389 187/7206 2.35869301928e-10 ko05321 Inflammatory bowel disease (IBD) 18/389 56/7206 3.28366075021e-10 ko04610 Complement and coagulation cascades 21/389 79/7206 5.75771938587e-10 ko04630 Jak-STAT signaling pathway 27/389 132/7206 1.22546730006e-09 ko05168 Herpes simplex infection 32/389 182/7206 1.97119590241e-09 ko05340 Primary immunodeficiency 12/389 30/7206 1.84767906148e-08 ko05133 Pertussis 20/389 87/7206 2.27748317082e-08 ko04650 Natural killer cell mediated cytotoxicity 21/389 97/7206 3.12927099788e-08 ko05323 Rheumatoid arthritis 20/389 89/7206 3.43902361132e-08 ko05145 Toxoplasmosis 24/389 126/7206 4.52470117594e-08 ko04217 Necroptosis 29/389 178/7206 6.76204423248e-08 ko05150 Staphylococcus aureus infection 12/389 36/7206 1.98822821473e-07 ko05167 Kaposi's sarcoma-associated herpesvirus infection 29/389 191/7206 3.23544491815e-07 ko05144 Malaria 13/389 45/7206 4.06923674069e-07 ko04933 AGE-RAGE signaling pathway in diabetic complications 23/389 135/7206 7.11179995854e-07 ko04659 Th17 cell differentiation 20/389 106/7206 7.19654444694e-07 ko04623 Cytosolic DNA-sensing pathway 12/389 41/7206 9.80478354233e-07 ko05142 Chagas disease (American trypanosomiasis) 22/389 130/7206 1.40103754974e-06 ko04660 T cell receptor signaling pathway 21/389 124/7206 2.41018392596e-06 ko04658 Th1 and Th2 cell differentiation 18/389 96/7206 2.85966955067e-06 ko04657 IL-17 signaling pathway 17/389 87/7206 2.99431961923e-06 ko04210 Apoptosis 26/389 180/7206 3.50172229279e-06 ko05132 Salmonella infection 17/389 98/7206 1.59912903432e-05 ko04622 RIG-I-like receptor signaling pathway 13/389 62/7206 1.99924918544e-05 ko05330 Allograft rejection 8/389 24/7206 2.29766595342e-05 ko05332 Graft-versus-host disease 7/389 18/7206 2.39822560121e-05 ko04662 B cell receptor signaling pathway 15/389 88/7206 6.22535001653e-05 ko05166 HTLV-I infection 32/389 292/7206 0.000102466985671 ko05320 Autoimmune thyroid disease 8/389 29/7206 0.000105630039547 ko04672 Intestinal immune network for IgA production 9/389 37/7206 0.00011433553486 ko05134 Legionellosis 13/389 74/7206 0.000139474351516 ko05160 Hepatitis C 20/389 153/7206 0.000195613566622 ko04940 Type I diabetes mellitus 8/389 32/7206 0.00022441330924 ko04612 Antigen processing and presentation 12/389 77/7206 0.000780646182643 ko04137 Mitophagy - animal 12/389 82/7206 0.00137948432707 ko05310 Asthma 5/389 17/7206 0.00161064402852 ko04640 Hematopoietic cell lineage 10/389 64/7206 0.00206708067638 ko05418 Fluid shear stress and atherosclerosis 19/389 173/7206 0.00305674557613 ko04724 Glutamatergic synapse 1/389 152/7206 0.00327585201449 ko03040 Spliceosome 1/389 145/7206 0.00477340541334 ko05020 Prion diseases 7/389 40/7206 0.0050205143269 ko05034 Alcoholism 4/389 238/7206 0.00531894313758 ko04115 p53 signaling pathway 10/389 74/7206 0.00607333552413 ko05143 African trypanosomiasis 6/389 32/7206 0.00652084338409 ko04917 Prolactin signaling pathway 11/389 87/7206 0.00680902665254 ko04666 Fc gamma R-mediated phagocytosis 14/389 122/7206 0.006928181753 ko04114 Oocyte meiosis 1/389 139/7206 0.00698215707989 ko04066 HIF-1 signaling pathway 14/389 123/7206 0.00730561692472 ko04611 Platelet activation 17/389 163/7206 0.00781098228319 ko05146 Amoebiasis 12/389 99/7206 0.0107038127848 ko05169 Epstein-Barr virus infection 20/389 206/7206 0.0110262923183 ko04932 Non-alcoholic fatty liver disease (NAFLD) 18/389 182/7206 0.0116270064008 ko04068 FoxO signaling pathway 17/389 167/7206 0.013387094784 ko04062 Chemokine signaling pathway 19/389 201/7206 0.0162479822071 ko04145 Phagosome 16/389 162/7206 0.0199306063546 ko04360 Axon guidance 5/389 233/7206 0.0254466481227 ko04144 Endocytosis 28/389 342/7206 0.0263951317528 ko05416 Viral myocarditis 7/389 55/7206 0.0274177566498 ko04920 Adipocytokine signaling pathway 10/389 89/7206 0.0280137111133 ko04727 GABAergic synapse 1/389 110/7206 0.0308180223808 ko04713 Circadian entrainment 2/389 136/7206 0.0342796484444 ko04550 Signaling pathways regulating pluripotency of stem cells 3/389 165/7206 0.0353481414438 ko04664 Fc epsilon RI signaling pathway 9/389 77/7206 0.035779959569 ko04916 Melanogenesis 2/389 142/7206 0.0357995917972 ko04218 Cellular senescence 16/389 177/7206 0.0409657431093 ko04010 MAPK signaling pathway 26/389 321/7206 0.041691486329 ko05131 Shigellosis 9/389 82/7206 0.0421503323365 ko04670 Leukocyte transendothelial migration 14/389 151/7206 0.0431608384605 ko05212 Pancreatic cancer 9/389 83/7206 0.0438350813656 ko04720 Long-term potentiation 1/389 99/7206 0.0438757196953 ko04914 Progesterone-mediated oocyte maturation 1/389 104/7206 0.0450223587934 ko04624 Toll and Imd signaling pathway 6/389 49/7206 0.0468510597386 ko04728 Dopaminergic synapse 4/389 185/7206 0.0468542892856 ko04390 Hippo signaling pathway 4/389 188/7206 0.0474559592283