ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 21/152 134/7206 3.69182537347e-13 ko04621 NOD-like receptor signaling pathway 19/152 157/7206 5.42607359201e-10 ko05164 Influenza A 19/152 167/7206 1.5731016598e-09 ko05160 Hepatitis C 18/152 153/7206 2.54080404474e-09 ko05161 Hepatitis B 19/152 173/7206 2.86994288633e-09 ko05167 Kaposi's sarcoma-associated herpesvirus infection 19/152 191/7206 1.5051298531e-08 ko05162 Measles 15/152 120/7206 2.56629799977e-08 ko04060 Cytokine-cytokine receptor interaction 18/152 191/7206 8.60027733795e-08 ko04064 NF-kappa B signaling pathway 13/152 96/7206 8.74817068628e-08 ko04620 Toll-like receptor signaling pathway 13/152 100/7206 1.43321676788e-07 ko04217 Necroptosis 17/152 178/7206 1.6616925755e-07 ko04668 TNF signaling pathway 14/152 120/7206 1.85126765776e-07 ko04630 Jak-STAT signaling pathway 14/152 132/7206 6.09074375984e-07 ko05168 Herpes simplex infection 16/152 182/7206 1.20964815622e-06 ko04622 RIG-I-like receptor signaling pathway 9/152 62/7206 5.09684139908e-06 ko05145 Toxoplasmosis 12/152 126/7206 1.23523540168e-05 ko04917 Prolactin signaling pathway 10/152 87/7206 1.28982257384e-05 ko05321 Inflammatory bowel disease (IBD) 8/152 56/7206 1.96311380885e-05 ko05140 Leishmaniasis 9/152 75/7206 2.49836053192e-05 ko04062 Chemokine signaling pathway 14/152 201/7206 8.0583880512e-05 ko04210 Apoptosis 13/152 180/7206 0.000101253776589 ko04660 T cell receptor signaling pathway 10/152 124/7206 0.000270120548986 ko04657 IL-17 signaling pathway 8/152 87/7206 0.00046512638067 ko04662 B cell receptor signaling pathway 8/152 88/7206 0.000502637677312 ko04672 Intestinal immune network for IgA production 5/152 37/7206 0.000988329188462 ko05132 Salmonella infection 8/152 98/7206 0.00103062823062 ko04623 Cytosolic DNA-sensing pathway 5/152 41/7206 0.00158794759369 ko05142 Chagas disease (American trypanosomiasis) 9/152 130/7206 0.00163699564992 ko05131 Shigellosis 7/152 82/7206 0.00163805674823 ko04933 AGE-RAGE signaling pathway in diabetic complications 9/152 135/7206 0.0021257888771 ko04931 Insulin resistance 9/152 137/7206 0.00235123489896 ko05323 Rheumatoid arthritis 7/152 89/7206 0.00262663242306 ko05120 Epithelial cell signaling in Helicobacter pylori infection 7/152 92/7206 0.00316907664067 ko05340 Primary immunodeficiency 4/152 30/7206 0.00340221914516 ko04658 Th1 and Th2 cell differentiation 7/152 96/7206 0.0040209387887 ko05169 Epstein-Barr virus infection 11/152 206/7206 0.00407877088831 ko04115 p53 signaling pathway 6/152 74/7206 0.0045422808016 ko05152 Tuberculosis 10/152 187/7206 0.00603548385859 ko04659 Th17 cell differentiation 7/152 106/7206 0.0069069174915 ko00120 Primary bile acid biosynthesis 3/152 20/7206 0.0080606261735 ko05215 Prostate cancer 7/152 111/7206 0.00882464806015 ko00140 Steroid hormone biosynthesis 4/152 41/7206 0.0105141045683 ko04920 Adipocytokine signaling pathway 6/152 89/7206 0.0110199948544 ko04218 Cellular senescence 9/152 177/7206 0.0123325774648 ko04080 Neuroactive ligand-receptor interaction 2/152 423/7206 0.0128366374373 ko05144 Malaria 4/152 45/7206 0.014500352132 ko05134 Legionellosis 5/152 74/7206 0.0196266950375 ko04145 Phagosome 8/152 162/7206 0.0209638142451 ko04612 Antigen processing and presentation 5/152 77/7206 0.0229022826697 ko04930 Type II diabetes mellitus 4/152 54/7206 0.0266286072939 ko04320 Dorso-ventral axis formation 3/152 31/7206 0.0268614064072 ko05212 Pancreatic cancer 5/152 83/7206 0.0304699113817 ko05166 HTLV-I infection 12/152 292/7206 0.0333375783711 ko05133 Pertussis 5/152 87/7206 0.0362965766849 ko04666 Fc gamma R-mediated phagocytosis 6/152 122/7206 0.0437955698212 ko04211 Longevity regulating pathway 6/152 123/7206 0.045272876837 ko04066 HIF-1 signaling pathway 6/152 123/7206 0.045272876837 ko04010 MAPK signaling pathway 12/152 321/7206 0.0457488736108 ko05203 Viral carcinogenesis 11/152 277/7206 0.0494100957969