ko pathway ratio_in_study ratio_in_pop p_value ko04668 TNF signaling pathway 19/213 120/7206 1.64861228251e-09 ko04380 Osteoclast differentiation 20/213 134/7206 1.75994761506e-09 ko04060 Cytokine-cytokine receptor interaction 21/213 191/7206 1.71008816853e-07 ko04621 NOD-like receptor signaling pathway 16/213 157/7206 1.42928529713e-05 ko05160 Hepatitis C 15/213 153/7206 4.21728215207e-05 ko04657 IL-17 signaling pathway 11/213 87/7206 4.52907894143e-05 ko05323 Rheumatoid arthritis 10/213 89/7206 0.000272596284555 ko04512 ECM-receptor interaction 9/213 79/7206 0.00049705898403 ko04630 Jak-STAT signaling pathway 12/213 132/7206 0.000502103028759 ko05132 Salmonella infection 10/213 98/7206 0.000595855934253 ko05131 Shigellosis 9/213 82/7206 0.000655634938727 ko04510 Focal adhesion 17/213 240/7206 0.000710196404882 ko04210 Apoptosis 14/213 180/7206 0.000850509009326 ko05164 Influenza A 13/213 167/7206 0.00128730117456 ko05161 Hepatitis B 13/213 173/7206 0.00177335662535 ko04064 NF-kappa B signaling pathway 9/213 96/7206 0.00203145152452 ko05100 Bacterial invasion of epithelial cells 9/213 99/7206 0.00251333024256 ko04620 Toll-like receptor signaling pathway 9/213 100/7206 0.00269270866038 ko04660 T cell receptor signaling pathway 10/213 124/7206 0.00356887984909 ko05145 Toxoplasmosis 10/213 126/7206 0.00400403960223 ko04917 Prolactin signaling pathway 8/213 87/7206 0.00402506938037 ko05133 Pertussis 8/213 87/7206 0.00402506938037 ko04672 Intestinal immune network for IgA production 5/213 37/7206 0.00434102735121 ko00643 Styrene degradation 2/213 4/7206 0.00501684988369 ko05120 Epithelial cell signaling in Helicobacter pylori infection 8/213 92/7206 0.00565621575754 ko04933 AGE-RAGE signaling pathway in diabetic complications 10/213 135/7206 0.00650766014867 ko04610 Complement and coagulation cascades 7/213 79/7206 0.00854498932464 ko05144 Malaria 5/213 45/7206 0.0100586179464 ko05168 Herpes simplex infection 12/213 182/7206 0.011495446125 ko05219 Bladder cancer 5/213 48/7206 0.0131301255677 ko04151 PI3K-Akt signaling pathway 20/213 390/7206 0.0135762732005 ko05167 Kaposi's sarcoma-associated herpesvirus infection 12/213 191/7206 0.0138659080035 ko04810 Regulation of actin cytoskeleton 15/213 264/7206 0.0142570792495 ko05142 Chagas disease (American trypanosomiasis) 9/213 130/7206 0.0146098578721 ko04662 B cell receptor signaling pathway 7/213 88/7206 0.0149927038386 ko04915 Estrogen signaling pathway 9/213 131/7206 0.0152983479831 ko00350 Tyrosine metabolism 4/213 33/7206 0.0155160068576 ko04068 FoxO signaling pathway 11/213 167/7206 0.0166857657371 ko04931 Insulin resistance 9/213 137/7206 0.0199411309228 ko05134 Legionellosis 6/213 74/7206 0.0217186221458 ko04115 p53 signaling pathway 6/213 74/7206 0.0217186221458 ko04932 Non-alcoholic fatty liver disease (NAFLD) 11/213 182/7206 0.0227687671823 ko04974 Protein digestion and absorption 7/213 96/7206 0.0231339502825 ko04658 Th1 and Th2 cell differentiation 7/213 96/7206 0.0231339502825 ko05321 Inflammatory bowel disease (IBD) 5/213 56/7206 0.0242542493346 ko05162 Measles 8/213 120/7206 0.025417851499 ko00401 Novobiocin biosynthesis 1/213 1/7206 0.0295587010825 ko01522 Endocrine resistance 8/213 124/7206 0.030163841826 ko05166 HTLV-I infection 15/213 292/7206 0.0328207812068 ko05418 Fluid shear stress and atherosclerosis 10/213 173/7206 0.037286847696 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 2/213 11/7206 0.0401258857108 ko04010 MAPK signaling pathway 16/213 321/7206 0.0404111907388 ko05210 Colorectal cancer 6/213 86/7206 0.0413324362148 ko04670 Leukocyte transendothelial migration 9/213 151/7206 0.0448600304383 ko04920 Adipocytokine signaling pathway 6/213 89/7206 0.0475567630682 ko04215 Apoptosis - multiple species 4/213 47/7206 0.0492426342729