ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	199/1222	423/7206	3.20210925196e-50
ko04724	Glutamatergic synapse	92/1222	152/7206	2.89369225985e-34
ko05033	Nicotine addiction	50/1222	56/7206	1.43477521744e-32
ko05032	Morphine addiction	68/1222	110/7206	2.49359983495e-26
ko04727	GABAergic synapse	67/1222	110/7206	2.03950393489e-25
ko04713	Circadian entrainment	74/1222	136/7206	1.07373945974e-23
ko04721	Synaptic vesicle cycle	53/1222	80/7206	7.55311235208e-23
ko04728	Dopaminergic synapse	85/1222	185/7206	1.27687767855e-20
ko04725	Cholinergic synapse	76/1222	160/7206	1.31106292153e-19
ko04723	Retrograde endocannabinoid signaling	78/1222	175/7206	4.888676151e-18
ko04024	cAMP signaling pathway	105/1222	279/7206	3.10121242421e-17
ko04742	Taste transduction	39/1222	61/7206	2.47051545154e-16
ko04020	Calcium signaling pathway	96/1222	265/7206	1.81402828233e-14
ko04744	Phototransduction	27/1222	36/7206	2.39315772169e-14
ko04911	Insulin secretion	54/1222	117/7206	1.26796040177e-13
ko04921	Oxytocin signaling pathway	79/1222	209/7206	3.20723860379e-13
ko04726	Serotonergic synapse	58/1222	137/7206	1.51572334019e-12
ko04720	Long-term potentiation	46/1222	99/7206	6.33894679721e-12
ko05031	Amphetamine addiction	43/1222	91/7206	1.55273926632e-11
ko04740	Olfactory transduction	39/1222	80/7206	4.1753733621e-11
ko04261	Adrenergic signaling in cardiomyocytes	73/1222	205/7206	7.11747675912e-11
ko03040	Spliceosome	1/1222	145/7206	7.14905702288e-11
ko04360	Axon guidance	78/1222	233/7206	4.00838575653e-10
ko04970	Salivary secretion	40/1222	95/7206	5.62264415439e-09
ko05203	Viral carcinogenesis	15/1222	277/7206	6.52934510108e-09
ko05030	Cocaine addiction	32/1222	73/7206	6.0287149161e-08
ko05168	Herpes simplex infection	7/1222	182/7206	6.10860497466e-08
ko04060	Cytokine-cytokine receptor interaction	8/1222	191/7206	7.44132841336e-08
ko04971	Gastric acid secretion	38/1222	98/7206	1.98025431435e-07
ko04966	Collecting duct acid secretion	16/1222	26/7206	4.12592141362e-07
ko04925	Aldosterone synthesis and secretion	39/1222	105/7206	5.50838160341e-07
ko03013	RNA transport	7/1222	166/7206	5.73725251165e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1222	74/7206	1.20907732648e-06
ko04022	cGMP-PKG signaling pathway	65/1222	216/7206	1.22536090321e-06
ko05164	Influenza A	9/1222	167/7206	8.95402281066e-06
ko04621	NOD-like receptor signaling pathway	8/1222	157/7206	1.21764273527e-05
ko04540	Gap junction	42/1222	128/7206	1.22964493065e-05
ko04010	MAPK signaling pathway	85/1222	321/7206	1.23284747554e-05
ko04610	Complement and coagulation cascades	1/1222	79/7206	1.26754708651e-05
ko04141	Protein processing in endoplasmic reticulum	11/1222	184/7206	1.42469818262e-05
ko04924	Renin secretion	31/1222	86/7206	1.64851423199e-05
ko05322	Systemic lupus erythematosus	8/1222	151/7206	2.37211484937e-05
ko04514	Cell adhesion molecules (CAMs)	41/1222	130/7206	4.40489390793e-05
ko04120	Ubiquitin mediated proteolysis	7/1222	138/7206	4.5569314149e-05
ko05110	Vibrio cholerae infection	24/1222	63/7206	5.52846207601e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1222	79/7206	5.98115484834e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1222	79/7206	0.000110637009442
ko05162	Measles	6/1222	120/7206	0.000114943601645
ko05205	Proteoglycans in cancer	24/1222	271/7206	0.000135076689241
ko05169	Epstein-Barr virus infection	16/1222	206/7206	0.000147245397981
ko04972	Pancreatic secretion	35/1222	111/7206	0.00016559680715
ko05414	Dilated cardiomyopathy	35/1222	112/7206	0.000181635700084
ko04730	Long-term depression	27/1222	78/7206	0.00018213248805
ko04064	NF-kappa B signaling pathway	4/1222	96/7206	0.000183574564047
ko04745	Phototransduction - fly	16/1222	38/7206	0.000224644811415
ko05140	Leishmaniasis	2/1222	75/7206	0.000258638232064
ko04260	Cardiac muscle contraction	31/1222	98/7206	0.000333994614318
ko04072	Phospholipase D signaling pathway	53/1222	197/7206	0.000342581592782
ko04110	Cell cycle	10/1222	145/7206	0.000479940764615
ko04070	Phosphatidylinositol signaling system	34/1222	112/7206	0.000498555724355
ko04146	Peroxisome	4/1222	89/7206	0.000551368899219
ko04976	Bile secretion	26/1222	80/7206	0.000756433391914
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1222	14/7206	0.000764784203494
ko04014	Ras signaling pathway	69/1222	279/7206	0.000797717748282
ko00480	Glutathione metabolism	1/1222	55/7206	0.000843596546093
ko05161	Hepatitis B	14/1222	173/7206	0.000953467320731
ko00590	Arachidonic acid metabolism	1/1222	52/7206	0.00125095308902
ko04626	Plant-pathogen interaction	9/1222	18/7206	0.00126642518171
ko04915	Estrogen signaling pathway	37/1222	131/7206	0.00133087756123
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1222	59/7206	0.00137336874826
ko04214	Apoptosis - fly	3/1222	72/7206	0.0014464647425
ko04964	Proximal tubule bicarbonate reclamation	12/1222	29/7206	0.00163831471999
ko00240	Pyrimidine metabolism	7/1222	110/7206	0.00185922976641
ko04750	Inflammatory mediator regulation of TRP channels	34/1222	122/7206	0.00219169136903
ko04612	Antigen processing and presentation	4/1222	77/7206	0.00332197010592
ko05321	Inflammatory bowel disease (IBD)	2/1222	56/7206	0.00375973481692
ko04371	Apelin signaling pathway	45/1222	177/7206	0.00425566888233
ko03022	Basal transcription factors	1/1222	44/7206	0.00428199007828
ko05144	Malaria	1/1222	45/7206	0.00433673848619
ko00071	Fatty acid degradation	1/1222	45/7206	0.00433673848619
ko03420	Nucleotide excision repair	1/1222	46/7206	0.00457352694884
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1222	182/7206	0.00482569760107
ko04923	Regulation of lipolysis in adipocytes	23/1222	77/7206	0.00525466166567
ko04622	RIG-I-like receptor signaling pathway	3/1222	62/7206	0.00628540046017
ko04640	Hematopoietic cell lineage	3/1222	64/7206	0.00647785462359
ko00310	Lysine degradation	4/1222	73/7206	0.00684786635759
ko04657	IL-17 signaling pathway	6/1222	87/7206	0.00914717473924
ko05133	Pertussis	6/1222	87/7206	0.00914717473924
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1222	40/7206	0.0097720620862
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1222	100/7206	0.0103422951507
ko05145	Toxoplasmosis	11/1222	126/7206	0.0114287720946
ko03018	RNA degradation	6/1222	84/7206	0.0125000489158
ko01524	Platinum drug resistance	5/1222	76/7206	0.0130692769344
ko04630	Jak-STAT signaling pathway	12/1222	132/7206	0.0135035109655
ko05206	MicroRNAs in cancer	18/1222	177/7206	0.0144901555684
ko00982	Drug metabolism - cytochrome P450	1/1222	37/7206	0.0145226020033
ko00630	Glyoxylate and dicarboxylate metabolism	1/1222	38/7206	0.0148890678813
ko05131	Shigellosis	6/1222	82/7206	0.0171013066926
ko05418	Fluid shear stress and atherosclerosis	18/1222	173/7206	0.0181457476677
ko04115	p53 signaling pathway	5/1222	74/7206	0.0182379489053
ko04668	TNF signaling pathway	11/1222	120/7206	0.0194527965245
ko04658	Th1 and Th2 cell differentiation	8/1222	96/7206	0.0198026160522
ko05166	HTLV-I infection	35/1222	292/7206	0.0207129335605
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1222	92/7206	0.0246002061226
ko00330	Arginine and proline metabolism	4/1222	61/7206	0.0256181955693
ko00600	Sphingolipid metabolism	4/1222	63/7206	0.0264597851109
ko04912	GnRH signaling pathway	30/1222	122/7206	0.0282147471038
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1222	15/7206	0.0294927351554
ko04916	Melanogenesis	34/1222	142/7206	0.0312775220799
ko04620	Toll-like receptor signaling pathway	9/1222	100/7206	0.0313412197817
ko00562	Inositol phosphate metabolism	23/1222	89/7206	0.032037901432
ko05016	Huntington's disease	25/1222	215/7206	0.0336978956221
ko03320	PPAR signaling pathway	5/1222	69/7206	0.0343167393472
ko04210	Apoptosis	20/1222	180/7206	0.0343308922976
ko05034	Alcoholism	53/1222	238/7206	0.0344951053932
ko00140	Steroid hormone biosynthesis	2/1222	41/7206	0.0360169231826
ko00380	Tryptophan metabolism	3/1222	50/7206	0.0365939772809
ko04015	Rap1 signaling pathway	60/1222	278/7206	0.0412985460204
ko04918	Thyroid hormone synthesis	22/1222	86/7206	0.041689528244
ko04217	Necroptosis	20/1222	178/7206	0.0425020363048
ko05222	Small cell lung cancer	8/1222	89/7206	0.0457739980691
ko04350	TGF-beta signaling pathway	10/1222	103/7206	0.0473337783182
ko05320	Autoimmune thyroid disease	1/1222	29/7206	0.0484582553374