ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	201/1184	423/7206	4.97784162313e-54
ko04724	Glutamatergic synapse	89/1184	152/7206	1.06259234767e-32
ko05033	Nicotine addiction	48/1184	56/7206	3.67739761156e-30
ko05032	Morphine addiction	68/1184	110/7206	3.55238243567e-27
ko04713	Circadian entrainment	75/1184	136/7206	2.17090813341e-25
ko04727	GABAergic synapse	66/1184	110/7206	2.4746376223e-25
ko04728	Dopaminergic synapse	85/1184	185/7206	1.47769655623e-21
ko04721	Synaptic vesicle cycle	50/1184	80/7206	1.40331311984e-20
ko04723	Retrograde endocannabinoid signaling	78/1184	175/7206	7.02845771227e-19
ko04020	Calcium signaling pathway	102/1184	265/7206	1.20817833572e-18
ko04725	Cholinergic synapse	73/1184	160/7206	1.92486414356e-18
ko04024	cAMP signaling pathway	104/1184	279/7206	9.80033685478e-18
ko04742	Taste transduction	39/1184	61/7206	8.0850802623e-17
ko04911	Insulin secretion	55/1184	117/7206	7.03942135386e-15
ko04726	Serotonergic synapse	58/1184	137/7206	3.78593332094e-13
ko04921	Oxytocin signaling pathway	77/1184	209/7206	3.9739048643e-13
ko04261	Adrenergic signaling in cardiomyocytes	73/1184	205/7206	1.13226368815e-11
ko04360	Axon guidance	79/1184	233/7206	3.08581787878e-11
ko05031	Amphetamine addiction	41/1184	91/7206	1.08002092272e-10
ko03040	Spliceosome	1/1184	145/7206	1.92258021506e-10
ko04744	Phototransduction	23/1184	36/7206	1.98079479196e-10
ko04970	Salivary secretion	41/1184	95/7206	5.52336911255e-10
ko04720	Long-term potentiation	42/1184	99/7206	6.49640025948e-10
ko05203	Viral carcinogenesis	15/1184	277/7206	2.00559057781e-08
ko04740	Olfactory transduction	34/1184	80/7206	2.65052651756e-08
ko04022	cGMP-PKG signaling pathway	67/1184	216/7206	6.43226485475e-08
ko05030	Cocaine addiction	31/1184	73/7206	1.11620067183e-07
ko05168	Herpes simplex infection	7/1184	182/7206	1.39001964306e-07
ko04060	Cytokine-cytokine receptor interaction	8/1184	191/7206	1.67691880263e-07
ko04971	Gastric acid secretion	37/1184	98/7206	2.830078693e-07
ko04925	Aldosterone synthesis and secretion	39/1184	105/7206	3.31113027095e-07
ko03013	RNA transport	7/1184	166/7206	1.28330043775e-06
ko05322	Systemic lupus erythematosus	6/1184	151/7206	3.39892727469e-06
ko05164	Influenza A	8/1184	167/7206	6.34619005903e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1184	74/7206	8.67773511484e-06
ko04514	Cell adhesion molecules (CAMs)	41/1184	130/7206	1.96753175466e-05
ko04010	MAPK signaling pathway	82/1184	321/7206	1.9869405883e-05
ko04621	NOD-like receptor signaling pathway	8/1184	157/7206	2.60136374316e-05
ko04141	Protein processing in endoplasmic reticulum	11/1184	184/7206	2.84247466306e-05
ko04540	Gap junction	40/1184	128/7206	2.99680160474e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1184	79/7206	4.01396497959e-05
ko04120	Ubiquitin mediated proteolysis	7/1184	138/7206	6.5000427724e-05
ko04966	Collecting duct acid secretion	13/1184	26/7206	7.52421577538e-05
ko05205	Proteoglycans in cancer	22/1184	271/7206	7.55138411047e-05
ko04972	Pancreatic secretion	35/1184	111/7206	7.72097792981e-05
ko04924	Renin secretion	29/1184	86/7206	9.07098073546e-05
ko05110	Vibrio cholerae infection	23/1184	63/7206	0.000100202604148
ko05161	Hepatitis B	11/1184	173/7206	0.000102101737002
ko04745	Phototransduction - fly	16/1184	38/7206	0.000153418860164
ko04260	Cardiac muscle contraction	31/1184	98/7206	0.000164463786128
ko03008	Ribosome biogenesis in eukaryotes	2/1184	79/7206	0.000172754487329
ko05414	Dilated cardiomyopathy	34/1184	112/7206	0.000248282721845
ko04070	Phosphatidylinositol signaling system	34/1184	112/7206	0.000248282721845
ko05140	Leishmaniasis	2/1184	75/7206	0.000252405980011
ko04612	Antigen processing and presentation	2/1184	77/7206	0.000263498096527
ko05169	Epstein-Barr virus infection	16/1184	206/7206	0.000370542926532
ko04064	NF-kappa B signaling pathway	4/1184	96/7206	0.0004117085152
ko04750	Inflammatory mediator regulation of TRP channels	35/1184	122/7206	0.000740222396982
ko04014	Ras signaling pathway	67/1184	279/7206	0.000922151558921
ko04110	Cell cycle	10/1184	145/7206	0.000925799324691
ko04371	Apelin signaling pathway	46/1184	177/7206	0.000958092977628
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1184	182/7206	0.00158644533117
ko04730	Long-term depression	24/1184	78/7206	0.00172601776761
ko04630	Jak-STAT signaling pathway	9/1184	132/7206	0.00183153116739
ko04640	Hematopoietic cell lineage	2/1184	64/7206	0.00183407450899
ko04976	Bile secretion	24/1184	80/7206	0.00213610130995
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1184	59/7206	0.00235713355104
ko05162	Measles	8/1184	120/7206	0.00256926627725
ko00240	Pyrimidine metabolism	7/1184	110/7206	0.00258275633695
ko00330	Arginine and proline metabolism	2/1184	61/7206	0.00265759592031
ko00260	Glycine, serine and threonine metabolism	1/1184	48/7206	0.00292181295888
ko05219	Bladder cancer	1/1184	48/7206	0.00292181295888
ko04146	Peroxisome	5/1184	89/7206	0.00357678653335
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1184	14/7206	0.00374456875299
ko03420	Nucleotide excision repair	1/1184	46/7206	0.00440955646996
ko01524	Platinum drug resistance	4/1184	76/7206	0.00482336084662
ko00480	Glutathione metabolism	2/1184	55/7206	0.00566001974346
ko05321	Inflammatory bowel disease (IBD)	2/1184	56/7206	0.00573096075496
ko04915	Estrogen signaling pathway	34/1184	131/7206	0.00575260012441
ko04072	Phospholipase D signaling pathway	47/1184	197/7206	0.00616464466996
ko05215	Prostate cancer	8/1184	111/7206	0.00628401355245
ko03022	Basal transcription factors	1/1184	44/7206	0.00671077489584
ko03018	RNA degradation	5/1184	84/7206	0.00699658638095
ko05144	Malaria	1/1184	45/7206	0.0070737440732
ko00071	Fatty acid degradation	1/1184	45/7206	0.0070737440732
ko05145	Toxoplasmosis	10/1184	126/7206	0.00729934003419
ko00590	Arachidonic acid metabolism	2/1184	52/7206	0.00830210919299
ko04620	Toll-like receptor signaling pathway	7/1184	100/7206	0.00910917333131
ko04622	RIG-I-like receptor signaling pathway	3/1184	62/7206	0.00919675367753
ko04214	Apoptosis - fly	4/1184	72/7206	0.00967049098686
ko05131	Shigellosis	5/1184	82/7206	0.00987870405325
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1184	40/7206	0.00994452072374
ko00310	Lysine degradation	4/1184	73/7206	0.00996930878554
ko04140	Autophagy - animal	15/1184	164/7206	0.0100890725938
ko00380	Tryptophan metabolism	2/1184	50/7206	0.0120521763581
ko04658	Th1 and Th2 cell differentiation	7/1184	96/7206	0.0120968774294
ko04668	TNF signaling pathway	10/1184	120/7206	0.012758504795
ko04657	IL-17 signaling pathway	6/1184	87/7206	0.0127757331659
ko05133	Pertussis	6/1184	87/7206	0.0127757331659
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1184	100/7206	0.0137587740963
ko00630	Glyoxylate and dicarboxylate metabolism	1/1184	38/7206	0.0148132036207
ko03410	Base excision repair	1/1184	38/7206	0.0148132036207
ko01200	Carbon metabolism	11/1184	128/7206	0.0153916011487
ko05418	Fluid shear stress and atherosclerosis	17/1184	173/7206	0.0165299901131
ko04210	Apoptosis	18/1184	180/7206	0.0186166183587
ko04923	Regulation of lipolysis in adipocytes	21/1184	77/7206	0.0189433621312
ko04626	Plant-pathogen interaction	7/1184	18/7206	0.0190279245585
ko04015	Rap1 signaling pathway	60/1184	278/7206	0.0207557054329
ko04916	Melanogenesis	34/1184	142/7206	0.0213888821071
ko00982	Drug metabolism - cytochrome P450	1/1184	37/7206	0.0230220408919
ko05206	MicroRNAs in cancer	18/1184	177/7206	0.0233139523313
ko04115	p53 signaling pathway	5/1184	74/7206	0.0256572570501
ko00280	Valine, leucine and isoleucine degradation	3/1184	54/7206	0.0263580010329
ko04270	Vascular smooth muscle contraction	36/1184	154/7206	0.0271108045372
ko04918	Thyroid hormone synthesis	22/1184	86/7206	0.0273829891288
ko05222	Small cell lung cancer	7/1184	89/7206	0.0296002204437
ko04350	TGF-beta signaling pathway	9/1184	103/7206	0.0318298021627
ko04933	AGE-RAGE signaling pathway in diabetic complications	13/1184	135/7206	0.0339399399436
ko05220	Chronic myeloid leukemia	7/1184	85/7206	0.0389079817118
ko04930	Type II diabetes mellitus	15/1184	54/7206	0.0397282803193
ko04217	Necroptosis	19/1184	178/7206	0.0397987030392
ko04510	Focal adhesion	28/1184	240/7206	0.0416466811609
ko04964	Proximal tubule bicarbonate reclamation	9/1184	29/7206	0.0432128687486
ko04391	Hippo signaling pathway - fly	22/1184	90/7206	0.0448291432654