ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	180/959	423/7206	7.16544280158e-54
ko04724	Glutamatergic synapse	80/959	152/7206	1.108278629e-31
ko05033	Nicotine addiction	46/959	56/7206	1.85494679563e-31
ko05032	Morphine addiction	61/959	110/7206	5.37981285736e-26
ko04727	GABAergic synapse	59/959	110/7206	3.70261427439e-24
ko04713	Circadian entrainment	66/959	136/7206	1.1597225189e-23
ko04728	Dopaminergic synapse	77/959	185/7206	3.58766749537e-22
ko04723	Retrograde endocannabinoid signaling	72/959	175/7206	1.92972180392e-20
ko04725	Cholinergic synapse	66/959	160/7206	6.82408771185e-19
ko04024	cAMP signaling pathway	90/959	279/7206	5.79502666518e-17
ko04911	Insulin secretion	52/959	117/7206	8.68516639532e-17
ko04020	Calcium signaling pathway	85/959	265/7206	6.60101436309e-16
ko04721	Synaptic vesicle cycle	39/959	80/7206	1.52544467609e-14
ko04726	Serotonergic synapse	52/959	137/7206	2.21830879973e-13
ko04742	Taste transduction	31/959	61/7206	1.93289237864e-12
ko04921	Oxytocin signaling pathway	66/959	209/7206	3.09704186925e-12
ko05031	Amphetamine addiction	38/959	91/7206	1.37104413309e-11
ko04261	Adrenergic signaling in cardiomyocytes	62/959	205/7206	1.77242252503e-10
ko04720	Long-term potentiation	37/959	99/7206	1.13777025411e-09
ko04970	Salivary secretion	36/959	95/7206	1.22719321142e-09
ko04360	Axon guidance	65/959	233/7206	1.80902298708e-09
ko04925	Aldosterone synthesis and secretion	36/959	105/7206	2.73151879523e-08
ko03040	Spliceosome	1/959	145/7206	3.66437917806e-08
ko05203	Viral carcinogenesis	10/959	277/7206	3.98280048437e-08
ko05030	Cocaine addiction	28/959	73/7206	6.35256534255e-08
ko04971	Gastric acid secretion	32/959	98/7206	5.74494351446e-07
ko05322	Systemic lupus erythematosus	3/959	151/7206	1.37997012558e-06
ko04972	Pancreatic secretion	34/959	111/7206	1.48494983257e-06
ko04740	Olfactory transduction	27/959	80/7206	2.12691487043e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	25/959	74/7206	4.94958833959e-06
ko04514	Cell adhesion molecules (CAMs)	37/959	130/7206	5.032666292e-06
ko05168	Herpes simplex infection	6/959	182/7206	6.69623846351e-06
ko03013	RNA transport	5/959	166/7206	7.79707798014e-06
ko05164	Influenza A	5/959	167/7206	7.94763766529e-06
ko04010	MAPK signaling pathway	71/959	321/7206	1.00737844573e-05
ko04022	cGMP-PKG signaling pathway	52/959	216/7206	1.45466180466e-05
ko04744	Phototransduction	15/959	36/7206	2.36851044263e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/959	79/7206	2.99729628397e-05
ko04060	Cytokine-cytokine receptor interaction	8/959	191/7206	3.29355760053e-05
ko04120	Ubiquitin mediated proteolysis	4/959	138/7206	3.91967954258e-05
ko04730	Long-term depression	24/959	78/7206	5.82614715585e-05
ko04621	NOD-like receptor signaling pathway	6/959	157/7206	0.00011201819928
ko04540	Gap junction	33/959	128/7206	0.000115962036016
ko04260	Cardiac muscle contraction	27/959	98/7206	0.000141564412538
ko04745	Phototransduction - fly	14/959	38/7206	0.000215367502075
ko04141	Protein processing in endoplasmic reticulum	9/959	184/7206	0.000244128917942
ko04072	Phospholipase D signaling pathway	45/959	197/7206	0.000252838329664
ko04610	Complement and coagulation cascades	1/959	79/7206	0.000320488387759
ko03008	Ribosome biogenesis in eukaryotes	1/959	79/7206	0.000320488387759
ko04750	Inflammatory mediator regulation of TRP channels	30/959	122/7206	0.000649655302386
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/959	59/7206	0.000652308771883
ko05414	Dilated cardiomyopathy	28/959	112/7206	0.000673191809233
ko04070	Phosphatidylinositol signaling system	28/959	112/7206	0.000673191809233
ko04214	Apoptosis - fly	1/959	72/7206	0.000698016227419
ko04014	Ras signaling pathway	56/959	279/7206	0.00117548101103
ko05162	Measles	5/959	120/7206	0.00156683403957
ko05169	Epstein-Barr virus infection	13/959	206/7206	0.00166840645869
ko04924	Renin secretion	22/959	86/7206	0.00200043807613
ko05205	Proteoglycans in cancer	20/959	271/7206	0.00249744673897
ko04915	Estrogen signaling pathway	30/959	131/7206	0.0025102272521
ko04110	Cell cycle	8/959	145/7206	0.00409363862322
ko00240	Pyrimidine metabolism	5/959	110/7206	0.00419002869491
ko04932	Non-alcoholic fatty liver disease (NAFLD)	12/959	182/7206	0.00540359625455
ko04916	Melanogenesis	31/959	142/7206	0.00554362057391
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/959	14/7206	0.006341299045
ko04015	Rap1 signaling pathway	52/959	278/7206	0.00891578925228
ko04140	Autophagy - animal	11/959	164/7206	0.0100497389361
ko04964	Proximal tubule bicarbonate reclamation	9/959	29/7206	0.0104921532455
ko04612	Antigen processing and presentation	3/959	77/7206	0.0104993327506
ko05215	Prostate cancer	6/959	111/7206	0.0106187253256
ko04146	Peroxisome	4/959	89/7206	0.0110079517572
ko05161	Hepatitis B	12/959	173/7206	0.0120805097485
ko04930	Type II diabetes mellitus	14/959	54/7206	0.0134133608456
ko04330	Notch signaling pathway	2/959	62/7206	0.0136213541933
ko00330	Arginine and proline metabolism	2/959	61/7206	0.0136217586294
ko04217	Necroptosis	13/959	178/7206	0.0138230330805
ko00310	Lysine degradation	3/959	73/7206	0.0147394442516
ko04064	NF-kappa B signaling pathway	5/959	96/7206	0.0148810045133
ko05140	Leishmaniasis	3/959	75/7206	0.0151799696272
ko04966	Collecting duct acid secretion	8/959	26/7206	0.0163890235864
ko05410	Hypertrophic cardiomyopathy (HCM)	22/959	100/7206	0.0164696133069
ko04976	Bile secretion	18/959	80/7206	0.0201027169736
ko04973	Carbohydrate digestion and absorption	11/959	42/7206	0.0210951185862
ko05166	HTLV-I infection	26/959	292/7206	0.022053783325
ko04918	Thyroid hormone synthesis	19/959	86/7206	0.0238322478946
ko04371	Apelin signaling pathway	34/959	177/7206	0.0245222683958
ko04626	Plant-pathogen interaction	6/959	18/7206	0.024551563413
ko03022	Basal transcription factors	1/959	44/7206	0.0245679686737
ko05144	Malaria	1/959	45/7206	0.0249957675283
ko00071	Fatty acid degradation	1/959	45/7206	0.0249957675283
ko00620	Pyruvate metabolism	1/959	46/7206	0.0259237988758
ko03420	Nucleotide excision repair	1/959	46/7206	0.0259237988758
ko04630	Jak-STAT signaling pathway	9/959	132/7206	0.0269385812805
ko00480	Glutathione metabolism	2/959	55/7206	0.0279930858648
ko05321	Inflammatory bowel disease (IBD)	2/959	56/7206	0.0281371687616
ko04142	Lysosome	11/959	151/7206	0.0284140168404
ko04912	GnRH signaling pathway	25/959	122/7206	0.0301362790508
ko04218	Cellular senescence	14/959	177/7206	0.0326359527493
ko00980	Metabolism of xenobiotics by cytochrome P450	1/959	40/7206	0.0362448633572
ko00983	Drug metabolism - other enzymes	1/959	42/7206	0.0369185789161
ko04657	IL-17 signaling pathway	5/959	87/7206	0.0375496218666
ko05133	Pertussis	5/959	87/7206	0.0375496218666
ko01524	Platinum drug resistance	4/959	76/7206	0.0397923696665
ko00590	Arachidonic acid metabolism	2/959	52/7206	0.0399523282499
ko00600	Sphingolipid metabolism	3/959	63/7206	0.0405469961195
ko04640	Hematopoietic cell lineage	3/959	64/7206	0.0406452095058
ko00280	Valine, leucine and isoleucine degradation	2/959	54/7206	0.0411391196182
ko04210	Apoptosis	15/959	180/7206	0.0454186848832
ko04658	Th1 and Th2 cell differentiation	6/959	96/7206	0.0472969893952