ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 42/513 191/7206 2.07745450947e-11 ko04380 Osteoclast differentiation 29/513 134/7206 4.28998515004e-08 ko04610 Complement and coagulation cascades 21/513 79/7206 8.02224402733e-08 ko04621 NOD-like receptor signaling pathway 29/513 157/7206 1.49386827231e-06 ko00120 Primary bile acid biosynthesis 9/513 20/7206 3.61796959878e-06 ko05321 Inflammatory bowel disease (IBD) 14/513 56/7206 2.56984188108e-05 ko04710 Circadian rhythm 12/513 43/7206 2.96780844592e-05 ko05162 Measles 22/513 120/7206 3.13307201316e-05 ko05140 Leishmaniasis 16/513 75/7206 5.74675536176e-05 ko03013 RNA transport 1/513 166/7206 9.61376937057e-05 ko04658 Th1 and Th2 cell differentiation 18/513 96/7206 0.000120718162277 ko04064 NF-kappa B signaling pathway 18/513 96/7206 0.000120718162277 ko05150 Staphylococcus aureus infection 10/513 36/7206 0.000143577115069 ko05323 Rheumatoid arthritis 17/513 89/7206 0.000146394048988 ko05340 Primary immunodeficiency 9/513 30/7206 0.000161753197964 ko05164 Influenza A 26/513 167/7206 0.000167658994993 ko04672 Intestinal immune network for IgA production 10/513 37/7206 0.000184418957362 ko04630 Jak-STAT signaling pathway 22/513 132/7206 0.000191942082963 ko04620 Toll-like receptor signaling pathway 18/513 100/7206 0.000207222313229 ko05145 Toxoplasmosis 21/513 126/7206 0.000279425875854 ko04662 B cell receptor signaling pathway 16/513 88/7206 0.00041021405821 ko04650 Natural killer cell mediated cytotoxicity 17/513 97/7206 0.000428573511995 ko04659 Th17 cell differentiation 18/513 106/7206 0.000437240775601 ko05168 Herpes simplex infection 26/513 182/7206 0.0006072254075 ko05034 Alcoholism 5/513 238/7206 0.000763547213074 ko05152 Tuberculosis 26/513 187/7206 0.000810340729239 ko05144 Malaria 10/513 45/7206 0.00100775394156 ko03010 Ribosome 1/513 129/7206 0.00146706644815 ko04933 AGE-RAGE signaling pathway in diabetic complications 20/513 135/7206 0.00179333847238 ko05167 Kaposi's sarcoma-associated herpesvirus infection 25/513 191/7206 0.00253859372996 ko03040 Spliceosome 2/513 145/7206 0.00286114436769 ko03320 PPAR signaling pathway 12/513 69/7206 0.00312101816026 ko05160 Hepatitis C 21/513 153/7206 0.00355427108813 ko00950 Isoquinoline alkaloid biosynthesis 4/513 10/7206 0.00377112519261 ko05161 Hepatitis B 23/513 173/7206 0.00380971073946 ko04660 T cell receptor signaling pathway 18/513 124/7206 0.00384774152128 ko04640 Hematopoietic cell lineage 11/513 64/7206 0.00502430478881 ko04062 Chemokine signaling pathway 25/513 201/7206 0.00518207626067 ko00360 Phenylalanine metabolism 5/513 17/7206 0.00540941718827 ko04670 Leukocyte transendothelial migration 20/513 151/7206 0.00601705632112 ko04668 TNF signaling pathway 17/513 120/7206 0.00605346898263 ko00140 Steroid hormone biosynthesis 8/513 41/7206 0.007362094506 ko00350 Tyrosine metabolism 7/513 33/7206 0.00747715075582 ko04611 Platelet activation 21/513 163/7206 0.00784397860835 ko00592 alpha-Linolenic acid metabolism 5/513 19/7206 0.00903031214598 ko04068 FoxO signaling pathway 21/513 167/7206 0.00916539950566 ko05133 Pertussis 13/513 87/7206 0.0096966499092 ko00590 Arachidonic acid metabolism 9/513 52/7206 0.0102534663999 ko04217 Necroptosis 22/513 178/7206 0.0110313842619 ko04612 Antigen processing and presentation 12/513 77/7206 0.0110400407453 ko04622 RIG-I-like receptor signaling pathway 10/513 62/7206 0.0114500257286 ko04110 Cell cycle 3/513 145/7206 0.0131213083737 ko03015 mRNA surveillance pathway 1/513 93/7206 0.0139287224937 ko05142 Chagas disease (American trypanosomiasis) 17/513 130/7206 0.0142744182296 ko04120 Ubiquitin mediated proteolysis 3/513 138/7206 0.0180254654259 ko04111 Cell cycle - yeast 1/513 90/7206 0.0207024505231 ko04623 Cytosolic DNA-sensing pathway 7/513 41/7206 0.0240920629707 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/513 4/7206 0.0275590756591 ko04390 Hippo signaling pathway 6/513 188/7206 0.0304197756586 ko04072 Phospholipase D signaling pathway 22/513 197/7206 0.0337307057402 ko00330 Arginine and proline metabolism 9/513 61/7206 0.0383224035435 ko04070 Phosphatidylinositol signaling system 14/513 112/7206 0.0384813797926 ko04210 Apoptosis 20/513 180/7206 0.0399196984797 ko05134 Legionellosis 10/513 74/7206 0.0399636590459 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/513 5/7206 0.0437863891297 ko00982 Drug metabolism - cytochrome P450 6/513 37/7206 0.0445611885596 ko05230 Central carbon metabolism in cancer 11/513 81/7206 0.0453928484978 ko04137 Mitophagy - animal 11/513 82/7206 0.0466119161839