ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 42/718 191/7206 5.40788598444e-07 ko04710 Circadian rhythm 15/718 43/7206 8.62011563279e-06 ko04070 Phosphatidylinositol signaling system 26/718 112/7206 3.55992047512e-05 ko03010 Ribosome 1/718 129/7206 3.72223323848e-05 ko04380 Osteoclast differentiation 29/718 134/7206 5.17940875355e-05 ko00120 Primary bile acid biosynthesis 9/718 20/7206 5.622886512e-05 ko03013 RNA transport 3/718 166/7206 5.90205135901e-05 ko03040 Spliceosome 2/718 145/7206 6.02741220618e-05 ko04610 Complement and coagulation cascades 20/718 79/7206 6.47799425221e-05 ko04110 Cell cycle 3/718 145/7206 0.00036243586297 ko04020 Calcium signaling pathway 44/718 265/7206 0.000731118480915 ko04922 Glucagon signaling pathway 25/718 128/7206 0.000869533703691 ko04711 Circadian rhythm - fly 6/718 13/7206 0.000889654105016 ko04137 Mitophagy - animal 18/718 82/7206 0.00113790993723 ko05321 Inflammatory bowel disease (IBD) 13/718 56/7206 0.00282039797541 ko04630 Jak-STAT signaling pathway 24/718 132/7206 0.00307795918918 ko04745 Phototransduction - fly 10/718 38/7206 0.00321985493221 ko05323 Rheumatoid arthritis 18/718 89/7206 0.00347714066412 ko05322 Systemic lupus erythematosus 5/718 151/7206 0.00351602442689 ko05203 Viral carcinogenesis 14/718 277/7206 0.00395475578234 ko00564 Glycerophospholipid metabolism 19/718 99/7206 0.0057730660038 ko04921 Oxytocin signaling pathway 33/718 209/7206 0.0067560198202 ko03015 mRNA surveillance pathway 2/718 93/7206 0.00774871217478 ko04925 Aldosterone synthesis and secretion 19/718 105/7206 0.00837608067479 ko05152 Tuberculosis 30/718 187/7206 0.00875584470469 ko04621 NOD-like receptor signaling pathway 26/718 157/7206 0.00966934742928 ko04072 Phospholipase D signaling pathway 31/718 197/7206 0.0106347863941 ko04022 cGMP-PKG signaling pathway 33/718 216/7206 0.0110119037982 ko04068 FoxO signaling pathway 27/718 167/7206 0.012124401579 ko02010 ABC transporters 9/718 39/7206 0.0126268423045 ko04713 Circadian entrainment 23/718 136/7206 0.0128565352816 ko05224 Breast cancer 8/718 174/7206 0.0142587804358 ko05100 Bacterial invasion of epithelial cells 3/718 99/7206 0.0166790761696 ko00140 Steroid hormone biosynthesis 9/718 41/7206 0.0174520621045 ko04650 Natural killer cell mediated cytotoxicity 17/718 97/7206 0.0242706173627 ko04672 Intestinal immune network for IgA production 8/718 37/7206 0.0265801846239 ko00561 Glycerolipid metabolism 12/718 63/7206 0.0305217950799 ko04914 Progesterone-mediated oocyte maturation 4/718 104/7206 0.0314948156561 ko04111 Cell cycle - yeast 3/718 90/7206 0.0320593608599 ko00592 alpha-Linolenic acid metabolism 5/718 19/7206 0.0345144097726 ko05034 Alcoholism 14/718 238/7206 0.0355931600233 ko04966 Collecting duct acid secretion 6/718 26/7206 0.0389666922562 ko00350 Tyrosine metabolism 7/718 33/7206 0.0406375364175 ko04062 Chemokine signaling pathway 29/718 201/7206 0.0412338175118 ko04113 Meiosis - yeast 2/718 70/7206 0.0435992296844 ko04725 Cholinergic synapse 24/718 160/7206 0.0436609445923 ko00562 Inositol phosphate metabolism 15/718 89/7206 0.0469134249295 ko00010 Glycolysis / Gluconeogenesis 13/718 74/7206 0.0471088771848 ko00330 Arginine and proline metabolism 11/718 61/7206 0.0491838220017