ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	202/1232	423/7206	1.00589976312e-51
ko04724	Glutamatergic synapse	89/1232	152/7206	2.53811915997e-31
ko05033	Nicotine addiction	47/1232	56/7206	6.52426542893e-28
ko05032	Morphine addiction	67/1232	110/7206	3.33095594676e-25
ko04713	Circadian entrainment	76/1232	136/7206	4.53771088679e-25
ko04727	GABAergic synapse	65/1232	110/7206	1.94473482835e-23
ko04721	Synaptic vesicle cycle	52/1232	80/7206	1.07870197353e-21
ko04728	Dopaminergic synapse	86/1232	185/7206	5.00171734609e-21
ko04725	Cholinergic synapse	77/1232	160/7206	4.59780942329e-20
ko04020	Calcium signaling pathway	103/1232	265/7206	9.72039767317e-18
ko04024	cAMP signaling pathway	106/1232	279/7206	1.83140575838e-17
ko04723	Retrograde endocannabinoid signaling	77/1232	175/7206	3.2766541749e-17
ko04726	Serotonergic synapse	64/1232	137/7206	4.64348730361e-16
ko04742	Taste transduction	36/1232	61/7206	1.66268972898e-13
ko04911	Insulin secretion	54/1232	117/7206	1.79375135182e-13
ko04921	Oxytocin signaling pathway	78/1232	209/7206	1.09923122061e-12
ko04744	Phototransduction	25/1232	36/7206	4.69792767663e-12
ko03040	Spliceosome	1/1232	145/7206	7.21330818676e-11
ko05031	Amphetamine addiction	42/1232	91/7206	9.07931536666e-11
ko04970	Salivary secretion	42/1232	95/7206	4.86172054918e-10
ko04261	Adrenergic signaling in cardiomyocytes	71/1232	205/7206	6.82448475139e-10
ko03010	Ribosome	1/1232	129/7206	1.60162120726e-09
ko04720	Long-term potentiation	42/1232	99/7206	2.28224000604e-09
ko04925	Aldosterone synthesis and secretion	40/1232	105/7206	2.52465482165e-07
ko03013	RNA transport	7/1232	166/7206	5.71303392002e-07
ko04022	cGMP-PKG signaling pathway	66/1232	216/7206	7.95771069561e-07
ko05322	Systemic lupus erythematosus	6/1232	151/7206	9.76885340324e-07
ko05168	Herpes simplex infection	9/1232	182/7206	1.10489731416e-06
ko04621	NOD-like receptor signaling pathway	7/1232	157/7206	1.70903851326e-06
ko05203	Viral carcinogenesis	20/1232	277/7206	1.82170117339e-06
ko05164	Influenza A	8/1232	167/7206	1.96026798117e-06
ko04971	Gastric acid secretion	36/1232	98/7206	2.40030872072e-06
ko04966	Collecting duct acid secretion	15/1232	26/7206	3.37689920217e-06
ko05030	Cocaine addiction	29/1232	73/7206	4.56966931559e-06
ko04141	Protein processing in endoplasmic reticulum	11/1232	184/7206	9.7650087642e-06
ko04070	Phosphatidylinositol signaling system	38/1232	112/7206	1.18983108344e-05
ko04612	Antigen processing and presentation	1/1232	77/7206	1.22765809438e-05
ko04060	Cytokine-cytokine receptor interaction	12/1232	191/7206	1.40730475833e-05
ko04740	Olfactory transduction	30/1232	80/7206	1.44685558348e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1232	74/7206	1.63014024886e-05
ko04514	Cell adhesion molecules (CAMs)	42/1232	130/7206	1.73285417135e-05
ko04360	Axon guidance	66/1232	233/7206	1.77159954573e-05
ko04730	Long-term depression	28/1232	78/7206	5.45247569209e-05
ko04972	Pancreatic secretion	36/1232	111/7206	6.36803050199e-05
ko04072	Phospholipase D signaling pathway	56/1232	197/7206	6.9455311112e-05
ko04014	Ras signaling pathway	73/1232	279/7206	9.20055787719e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1232	79/7206	0.000113023622108
ko04110	Cell cycle	9/1232	145/7206	0.000132161095343
ko04120	Ubiquitin mediated proteolysis	8/1232	138/7206	0.000132186725253
ko04745	Phototransduction - fly	16/1232	38/7206	0.000247677430513
ko04976	Bile secretion	27/1232	80/7206	0.000256826501655
ko04010	MAPK signaling pathway	80/1232	321/7206	0.000259056223085
ko05169	Epstein-Barr virus infection	17/1232	206/7206	0.000323827569825
ko04540	Gap junction	38/1232	128/7206	0.000338811078098
ko04710	Circadian rhythm	17/1232	43/7206	0.000393917787711
ko04924	Renin secretion	28/1232	86/7206	0.000424588506489
ko05110	Vibrio cholerae infection	22/1232	63/7206	0.000569012045853
ko04750	Inflammatory mediator regulation of TRP channels	36/1232	122/7206	0.000595648721305
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1232	79/7206	0.000728979075285
ko04064	NF-kappa B signaling pathway	5/1232	96/7206	0.000880104535937
ko05161	Hepatitis B	14/1232	173/7206	0.000967522273778
ko05140	Leishmaniasis	3/1232	75/7206	0.000989465850943
ko05414	Dilated cardiomyopathy	33/1232	112/7206	0.00135120837483
ko04371	Apelin signaling pathway	47/1232	177/7206	0.00158335065625
ko05205	Proteoglycans in cancer	28/1232	271/7206	0.00173913041664
ko04964	Proximal tubule bicarbonate reclamation	12/1232	29/7206	0.00176240219055
ko05166	HTLV-I infection	31/1232	292/7206	0.00191966356564
ko04217	Necroptosis	16/1232	178/7206	0.00239701940507
ko03420	Nucleotide excision repair	1/1232	46/7206	0.00282125024532
ko05162	Measles	9/1232	120/7206	0.00313797359841
ko05145	Toxoplasmosis	10/1232	126/7206	0.00397395498934
ko04922	Glucagon signaling pathway	35/1232	128/7206	0.00410559870436
ko04260	Cardiac muscle contraction	28/1232	98/7206	0.00421319453037
ko03022	Basal transcription factors	1/1232	44/7206	0.00425087512509
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1232	59/7206	0.00458209408531
ko04915	Estrogen signaling pathway	35/1232	131/7206	0.00478133726296
ko04923	Regulation of lipolysis in adipocytes	23/1232	77/7206	0.00547489799097
ko04626	Plant-pathogen interaction	8/1232	18/7206	0.00620019715897
ko04330	Notch signaling pathway	3/1232	62/7206	0.00622856818191
ko04622	RIG-I-like receptor signaling pathway	3/1232	62/7206	0.00622856818191
ko04658	Th1 and Th2 cell differentiation	7/1232	96/7206	0.00882734595191
ko04657	IL-17 signaling pathway	6/1232	87/7206	0.00918786999624
ko05133	Pertussis	6/1232	87/7206	0.00918786999624
ko04930	Type II diabetes mellitus	17/1232	54/7206	0.00965008078993
ko04610	Complement and coagulation cascades	5/1232	79/7206	0.00966628423952
ko03018	RNA degradation	6/1232	84/7206	0.0124884640519
ko04115	p53 signaling pathway	5/1232	74/7206	0.0129399357284
ko04630	Jak-STAT signaling pathway	12/1232	132/7206	0.0136301499461
ko03410	Base excision repair	1/1232	38/7206	0.015031090762
ko04210	Apoptosis	19/1232	180/7206	0.0160050642224
ko05131	Shigellosis	6/1232	82/7206	0.0171964023722
ko04214	Apoptosis - fly	5/1232	72/7206	0.0178077687661
ko00280	Valine, leucine and isoleucine degradation	3/1232	54/7206	0.0182172763293
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1232	14/7206	0.0213863511436
ko00240	Pyrimidine metabolism	10/1232	110/7206	0.02148835809
ko00562	Inositol phosphate metabolism	24/1232	89/7206	0.0221374309472
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1232	100/7206	0.0224150699758
ko04510	Focal adhesion	28/1232	240/7206	0.0230611552007
ko04973	Carbohydrate digestion and absorption	13/1232	42/7206	0.0231113955713
ko00590	Arachidonic acid metabolism	3/1232	52/7206	0.0257919153798
ko05144	Malaria	2/1232	45/7206	0.0261217188257
ko00071	Fatty acid degradation	2/1232	45/7206	0.0261217188257
ko05231	Choline metabolism in cancer	33/1232	134/7206	0.0269234014319
ko04270	Vascular smooth muscle contraction	37/1232	154/7206	0.0296799476586
ko05217	Basal cell carcinoma	5/1232	68/7206	0.0338352475715
ko05200	Pathways in cancer	67/1232	492/7206	0.0347811593216
ko04912	GnRH signaling pathway	30/1232	122/7206	0.0381118933474
ko00310	Lysine degradation	6/1232	73/7206	0.0418750604979
ko04146	Peroxisome	8/1232	89/7206	0.0459684548499
ko05222	Small cell lung cancer	8/1232	89/7206	0.0459684548499
ko05340	Primary immunodeficiency	1/1232	30/7206	0.0487336478697
ko05321	Inflammatory bowel disease (IBD)	4/1232	56/7206	0.0488972526119
ko00480	Glutathione metabolism	4/1232	55/7206	0.0489157439276
ko05202	Transcriptional misregulation in cancer	22/1232	188/7206	0.0491909741915