ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 9/74 152/7206 2.2383810294e-05 ko04713 Circadian entrainment 8/74 136/7206 6.92061098816e-05 ko04360 Axon guidance 9/74 233/7206 0.000585814859588 ko04727 GABAergic synapse 6/74 110/7206 0.000880342414184 ko04912 GnRH signaling pathway 6/74 122/7206 0.00150809785743 ko04723 Retrograde endocannabinoid signaling 7/74 175/7206 0.00202094662645 ko00512 Mucin type O-glycan biosynthesis 3/74 29/7206 0.00313604047248 ko04080 Neuroactive ligand-receptor interaction 11/74 423/7206 0.00365555116399 ko04925 Aldosterone synthesis and secretion 5/74 105/7206 0.0043372008193 ko05032 Morphine addiction 5/74 110/7206 0.00528441187022 ko04070 Phosphatidylinositol signaling system 5/74 112/7206 0.00570146509084 ko05030 Cocaine addiction 4/74 73/7206 0.00653776090833 ko04728 Dopaminergic synapse 6/74 185/7206 0.0115364132349 ko04924 Renin secretion 4/74 86/7206 0.0115454899233 ko04918 Thyroid hormone synthesis 4/74 86/7206 0.0115454899233 ko00562 Inositol phosphate metabolism 4/74 89/7206 0.0129736574401 ko04726 Serotonergic synapse 5/74 137/7206 0.0130372664211 ko04916 Melanogenesis 5/74 142/7206 0.0150348829621 ko04971 Gastric acid secretion 4/74 98/7206 0.0179192091032 ko05033 Nicotine addiction 3/74 56/7206 0.019533666262 ko04022 cGMP-PKG signaling pathway 6/74 216/7206 0.0230842811778 ko04725 Cholinergic synapse 5/74 160/7206 0.0239038335368 ko04911 Insulin secretion 4/74 117/7206 0.0318289945005 ko04371 Apelin signaling pathway 5/74 177/7206 0.0348897408018 ko04750 Inflammatory mediator regulation of TRP channels 4/74 122/7206 0.0363075335134 ko04320 Dorso-ventral axis formation 2/74 31/7206 0.0399361620645 ko04540 Gap junction 4/74 128/7206 0.0421412987494 ko04923 Regulation of lipolysis in adipocytes 3/74 77/7206 0.0442921835625 ko04915 Estrogen signaling pathway 4/74 131/7206 0.0452467341908 ko04740 Olfactory transduction 3/74 80/7206 0.048687281506