ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 60/571 152/7206 6.61690980786e-28 ko04080 Neuroactive ligand-receptor interaction 101/571 423/7206 9.07369305163e-26 ko05033 Nicotine addiction 35/571 56/7206 3.0035175117e-25 ko04713 Circadian entrainment 48/571 136/7206 4.83549706744e-20 ko04728 Dopaminergic synapse 56/571 185/7206 1.40245728201e-19 ko05032 Morphine addiction 41/571 110/7206 2.86677967249e-18 ko04727 GABAergic synapse 38/571 110/7206 9.82204426137e-16 ko04723 Retrograde endocannabinoid signaling 49/571 175/7206 1.01156603839e-15 ko04024 cAMP signaling pathway 64/571 279/7206 1.63616426273e-15 ko04721 Synaptic vesicle cycle 31/571 80/7206 1.1957298068e-14 ko04725 Cholinergic synapse 45/571 160/7206 1.32787400395e-14 ko04911 Insulin secretion 37/571 117/7206 5.81716311977e-14 ko05031 Amphetamine addiction 29/571 91/7206 2.64732257752e-11 ko04720 Long-term potentiation 30/571 99/7206 4.98081453261e-11 ko04261 Adrenergic signaling in cardiomyocytes 45/571 205/7206 1.58790026192e-10 ko04020 Calcium signaling pathway 51/571 265/7206 1.56033393049e-09 ko05030 Cocaine addiction 23/571 73/7206 4.00717037312e-09 ko04921 Oxytocin signaling pathway 42/571 209/7206 1.11012625469e-08 ko05014 Amyotrophic lateral sclerosis (ALS) 21/571 74/7206 1.46225730479e-07 ko04726 Serotonergic synapse 30/571 137/7206 2.08159378049e-07 ko04970 Salivary secretion 24/571 95/7206 2.13839499515e-07 ko04742 Taste transduction 17/571 61/7206 2.99370557e-06 ko04745 Phototransduction - fly 13/571 38/7206 3.59843280373e-06 ko04060 Cytokine-cytokine receptor interaction 1/571 191/7206 3.95069893676e-06 ko04010 MAPK signaling pathway 49/571 321/7206 6.35863514641e-06 ko04971 Gastric acid secretion 21/571 98/7206 2.00422939205e-05 ko04740 Olfactory transduction 18/571 80/7206 3.92211993716e-05 ko04022 cGMP-PKG signaling pathway 35/571 216/7206 5.03279962373e-05 ko05203 Viral carcinogenesis 6/571 277/7206 5.64403846195e-05 ko04514 Cell adhesion molecules (CAMs) 24/571 130/7206 9.00216821801e-05 ko04730 Long-term depression 17/571 78/7206 9.79700685029e-05 ko04925 Aldosterone synthesis and secretion 20/571 105/7206 0.000179441421831 ko05164 Influenza A 2/571 167/7206 0.000214421364042 ko04626 Plant-pathogen interaction 7/571 18/7206 0.000277492117969 ko04924 Renin secretion 17/571 86/7206 0.000342276348268 ko05168 Herpes simplex infection 3/571 182/7206 0.000405218694856 ko04972 Pancreatic secretion 20/571 111/7206 0.000486001200016 ko04550 Signaling pathways regulating pluripotency of stem cells 3/571 165/7206 0.00115343685072 ko04360 Axon guidance 33/571 233/7206 0.00115482028819 ko05010 Alzheimer's disease 29/571 202/7206 0.00141258377427 ko04744 Phototransduction 9/571 36/7206 0.00155855559404 ko04915 Estrogen signaling pathway 21/571 131/7206 0.00160633276305 ko04260 Cardiac muscle contraction 17/571 98/7206 0.00190002619913 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/571 14/7206 0.00336126865588 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 14/571 79/7206 0.00471953383114 ko04140 Autophagy - animal 4/571 164/7206 0.0049871878912 ko03013 RNA transport 4/571 166/7206 0.00509878541963 ko04150 mTOR signaling pathway 5/571 184/7206 0.00518577290158 ko05166 HTLV-I infection 11/571 292/7206 0.00536976762569 ko05162 Measles 2/571 120/7206 0.00567985998959 ko04961 Endocrine and other factor-regulated calcium reabsorption 11/571 59/7206 0.00592582671046 ko04120 Ubiquitin mediated proteolysis 3/571 138/7206 0.00644332612266 ko05034 Alcoholism 31/571 238/7206 0.0067028184622 ko05161 Hepatitis B 5/571 173/7206 0.00962871828019 ko04750 Inflammatory mediator regulation of TRP channels 18/571 122/7206 0.00987692671169 ko04072 Phospholipase D signaling pathway 26/571 197/7206 0.0101984073423 ko05215 Prostate cancer 2/571 111/7206 0.0117202103207 ko04978 Mineral absorption 8/571 40/7206 0.0117873668334 ko04630 Jak-STAT signaling pathway 3/571 132/7206 0.0131992822144 ko05322 Systemic lupus erythematosus 4/571 151/7206 0.0135369506896 ko04966 Collecting duct acid secretion 6/571 26/7206 0.0141079848364 ko05205 Proteoglycans in cancer 11/571 271/7206 0.0153729956375 ko04973 Carbohydrate digestion and absorption 8/571 42/7206 0.0157403436362 ko04350 TGF-beta signaling pathway 2/571 103/7206 0.0162607246484 ko04114 Oocyte meiosis 19/571 139/7206 0.0166579038163 ko04932 Non-alcoholic fatty liver disease (NAFLD) 6/571 182/7206 0.0171083370562 ko04014 Ras signaling pathway 33/571 279/7206 0.0174390421692 ko03008 Ribosome biogenesis in eukaryotes 1/571 79/7206 0.0198055050948 ko00512 Mucin type O-glycan biosynthesis 6/571 29/7206 0.0237936258344 ko04964 Proximal tubule bicarbonate reclamation 6/571 29/7206 0.0237936258344 ko04621 NOD-like receptor signaling pathway 5/571 157/7206 0.0238398418296 ko04722 Neurotrophin signaling pathway 21/571 160/7206 0.0247104956672 ko05169 Epstein-Barr virus infection 8/571 206/7206 0.0256870167408 ko04510 Focal adhesion 10/571 240/7206 0.0278190262726 ko05140 Leishmaniasis 1/571 75/7206 0.0290417780401 ko04612 Antigen processing and presentation 1/571 77/7206 0.0301345898956 ko04922 Glucagon signaling pathway 17/571 128/7206 0.0308163276558 ko04540 Gap junction 17/571 128/7206 0.0308163276558 ko04371 Apelin signaling pathway 22/571 177/7206 0.0332277998498 ko04930 Type II diabetes mellitus 9/571 54/7206 0.0360645185354 ko04810 Regulation of actin cytoskeleton 12/571 264/7206 0.036333416935 ko04912 GnRH signaling pathway 16/571 122/7206 0.0410139631544 ko05217 Basal cell carcinoma 1/571 68/7206 0.0415595358954 ko04110 Cell cycle 5/571 145/7206 0.0424786051826 ko04214 Apoptosis - fly 1/571 72/7206 0.0437152106943 ko00513 Various types of N-glycan biosynthesis 7/571 42/7206 0.0449607161739 ko04146 Peroxisome 2/571 89/7206 0.0459813790192 ko00240 Pyrimidine metabolism 3/571 110/7206 0.047426286748