ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 39/390 191/7206 2.38249030479e-13 ko04380 Osteoclast differentiation 29/390 134/7206 7.34798988991e-11 ko04672 Intestinal immune network for IgA production 13/390 37/7206 3.04319587455e-08 ko05140 Leishmaniasis 18/390 75/7206 5.94171087018e-08 ko04658 Th1 and Th2 cell differentiation 20/390 96/7206 1.37700784446e-07 ko05340 Primary immunodeficiency 11/390 30/7206 2.18037977027e-07 ko05164 Influenza A 27/390 167/7206 2.40921121126e-07 ko04621 NOD-like receptor signaling pathway 26/390 157/7206 2.4882621017e-07 ko05162 Measles 22/390 120/7206 3.51521991101e-07 ko04064 NF-kappa B signaling pathway 19/390 96/7206 6.60241282538e-07 ko04650 Natural killer cell mediated cytotoxicity 19/390 97/7206 7.80885027199e-07 ko05145 Toxoplasmosis 22/390 126/7206 8.43808740693e-07 ko05321 Inflammatory bowel disease (IBD) 14/390 56/7206 1.0561777115e-06 ko04659 Th17 cell differentiation 19/390 106/7206 3.18314494183e-06 ko04610 Complement and coagulation cascades 16/390 79/7206 3.70861993382e-06 ko05168 Herpes simplex infection 26/390 182/7206 4.52309308429e-06 ko04620 Toll-like receptor signaling pathway 18/390 100/7206 5.4425443682e-06 ko04630 Jak-STAT signaling pathway 21/390 132/7206 7.00756317917e-06 ko04660 T cell receptor signaling pathway 20/390 124/7206 9.38629838902e-06 ko05323 Rheumatoid arthritis 16/390 89/7206 1.84293336079e-05 ko05161 Hepatitis B 23/390 173/7206 5.22324212333e-05 ko05150 Staphylococcus aureus infection 9/390 36/7206 9.26079111869e-05 ko05320 Autoimmune thyroid disease 8/390 29/7206 0.000107552820299 ko05144 Malaria 10/390 45/7206 0.000111228132802 ko05330 Allograft rejection 7/390 24/7206 0.000199795331751 ko05152 Tuberculosis 23/390 187/7206 0.000200819064884 ko05160 Hepatitis C 20/390 153/7206 0.000202452619878 ko04668 TNF signaling pathway 17/390 120/7206 0.000229268809304 ko04662 B cell receptor signaling pathway 14/390 88/7206 0.000239392720014 ko04933 AGE-RAGE signaling pathway in diabetic complications 18/390 135/7206 0.000326772802956 ko05034 Alcoholism 2/390 238/7206 0.000352860553951 ko05142 Chagas disease (American trypanosomiasis) 17/390 130/7206 0.000598121367036 ko04217 Necroptosis 21/390 178/7206 0.000629067687833 ko05167 Kaposi's sarcoma-associated herpesvirus infection 22/390 191/7206 0.000863353345586 ko04611 Platelet activation 19/390 163/7206 0.00132578510552 ko04062 Chemokine signaling pathway 22/390 201/7206 0.00135852852077 ko03013 RNA transport 1/390 166/7206 0.00153664154857 ko05310 Asthma 5/390 17/7206 0.00162922838786 ko05332 Graft-versus-host disease 5/390 18/7206 0.00215690114198 ko05133 Pertussis 12/390 87/7206 0.00236605771294 ko04612 Antigen processing and presentation 11/390 77/7206 0.00268283795602 ko00120 Primary bile acid biosynthesis 5/390 20/7206 0.00356875509225 ko04728 Dopaminergic synapse 2/390 185/7206 0.00438886345345 ko03040 Spliceosome 1/390 145/7206 0.00477588397664 ko04670 Leukocyte transendothelial migration 17/390 151/7206 0.00516688654466 ko05166 HTLV-I infection 27/390 292/7206 0.00535004869726 ko04622 RIG-I-like receptor signaling pathway 9/390 62/7206 0.00574578455223 ko04623 Cytosolic DNA-sensing pathway 7/390 41/7206 0.00586113030979 ko04723 Retrograde endocannabinoid signaling 2/390 175/7206 0.00612535436275 ko00590 Arachidonic acid metabolism 8/390 52/7206 0.00634015892195 ko04916 Melanogenesis 1/390 142/7206 0.00726532051605 ko04710 Circadian rhythm 7/390 43/7206 0.00765709737807 ko04664 Fc epsilon RI signaling pathway 10/390 77/7206 0.00817806678851 ko05215 Prostate cancer 13/390 111/7206 0.00867713034714 ko03010 Ribosome 1/390 129/7206 0.0100682973325 ko04068 FoxO signaling pathway 17/390 167/7206 0.0135003667243 ko04072 Phospholipase D signaling pathway 19/390 197/7206 0.0149942285405 ko01200 Carbon metabolism 1/390 128/7206 0.015466657224 ko05418 Fluid shear stress and atherosclerosis 17/390 173/7206 0.0157943930571 ko00592 alpha-Linolenic acid metabolism 4/390 19/7206 0.0171312109326 ko04310 Wnt signaling pathway 3/390 181/7206 0.018675638889 ko04640 Hematopoietic cell lineage 8/390 64/7206 0.021279696439 ko00140 Steroid hormone biosynthesis 6/390 41/7206 0.0217860332568 ko04666 Fc gamma R-mediated phagocytosis 13/390 122/7206 0.0229659485858 ko00051 Fructose and mannose metabolism 6/390 42/7206 0.0242979375805 ko00565 Ether lipid metabolism 6/390 42/7206 0.0242979375805 ko04940 Type I diabetes mellitus 5/390 32/7206 0.0272451003337 ko04210 Apoptosis 17/390 180/7206 0.0276445641242 ko05416 Viral myocarditis 7/390 55/7206 0.0277560018519 ko04972 Pancreatic secretion 1/390 111/7206 0.0312034899443 ko04114 Oocyte meiosis 2/390 139/7206 0.0347882325678 ko04145 Phagosome 15/390 162/7206 0.0348865133568 ko05131 Shigellosis 9/390 82/7206 0.0424825644947 ko04137 Mitophagy - animal 9/390 82/7206 0.0424825644947 ko04390 Hippo signaling pathway 4/390 188/7206 0.0476020627373