ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	176/1081	423/7206	5.63226225676e-43
ko04724	Glutamatergic synapse	85/1081	152/7206	2.97185267337e-32
ko05033	Nicotine addiction	45/1081	56/7206	1.06185357257e-27
ko05032	Morphine addiction	63/1081	110/7206	6.49290372769e-25
ko04713	Circadian entrainment	69/1081	136/7206	5.05023251679e-23
ko04727	GABAergic synapse	59/1081	110/7206	1.99041207498e-21
ko04721	Synaptic vesicle cycle	48/1081	80/7206	1.91736427739e-20
ko04728	Dopaminergic synapse	79/1081	185/7206	3.25513142939e-20
ko04725	Cholinergic synapse	69/1081	160/7206	4.59318663512e-18
ko04723	Retrograde endocannabinoid signaling	71/1081	175/7206	8.21182147497e-17
ko04024	cAMP signaling pathway	94/1081	279/7206	1.53555524951e-15
ko04020	Calcium signaling pathway	89/1081	265/7206	1.1771321236e-14
ko04744	Phototransduction	26/1081	36/7206	1.62303819204e-14
ko04921	Oxytocin signaling pathway	75/1081	209/7206	2.95415507122e-14
ko04742	Taste transduction	34/1081	61/7206	1.58465115632e-13
ko04911	Insulin secretion	48/1081	117/7206	5.71968723821e-12
ko04726	Serotonergic synapse	53/1081	137/7206	6.92018258374e-12
ko04261	Adrenergic signaling in cardiomyocytes	66/1081	205/7206	4.40644956973e-10
ko05031	Amphetamine addiction	37/1081	91/7206	2.13408443095e-09
ko03040	Spliceosome	1/1081	145/7206	2.18800204895e-09
ko04970	Salivary secretion	38/1081	95/7206	2.24872716488e-09
ko04740	Olfactory transduction	34/1081	80/7206	2.4261604863e-09
ko04720	Long-term potentiation	37/1081	99/7206	3.18329762008e-08
ko05203	Viral carcinogenesis	13/1081	277/7206	4.31623493601e-08
ko04022	cGMP-PKG signaling pathway	62/1081	216/7206	1.72536407534e-07
ko05322	Systemic lupus erythematosus	4/1081	151/7206	7.51723096422e-07
ko04925	Aldosterone synthesis and secretion	35/1081	105/7206	2.47239678662e-06
ko04060	Cytokine-cytokine receptor interaction	8/1081	191/7206	2.57130103544e-06
ko04971	Gastric acid secretion	33/1081	98/7206	2.8546837556e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1081	74/7206	3.96033422621e-06
ko04966	Collecting duct acid secretion	14/1081	26/7206	4.42244487107e-06
ko05168	Herpes simplex infection	8/1081	182/7206	7.24488350038e-06
ko04621	NOD-like receptor signaling pathway	6/1081	157/7206	7.91693348325e-06
ko05164	Influenza A	7/1081	167/7206	1.35125208659e-05
ko04360	Axon guidance	60/1081	233/7206	1.42490053265e-05
ko05030	Cocaine addiction	26/1081	73/7206	1.65039840532e-05
ko04514	Cell adhesion molecules (CAMs)	38/1081	130/7206	2.96874213399e-05
ko04120	Ubiquitin mediated proteolysis	5/1081	138/7206	2.9873086761e-05
ko04745	Phototransduction - fly	16/1081	38/7206	4.98540813542e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1081	79/7206	5.09312923722e-05
ko03013	RNA transport	8/1081	166/7206	5.83925475955e-05
ko04612	Antigen processing and presentation	1/1081	77/7206	7.97272779453e-05
ko04010	MAPK signaling pathway	74/1081	321/7206	8.35622185914e-05
ko04924	Renin secretion	27/1081	86/7206	0.000100774750888
ko04110	Cell cycle	7/1081	145/7206	0.000145278372527
ko05169	Epstein-Barr virus infection	13/1081	206/7206	0.000147635027365
ko04730	Long-term depression	25/1081	78/7206	0.000153009520441
ko05205	Proteoglycans in cancer	20/1081	271/7206	0.000171568683319
ko04141	Protein processing in endoplasmic reticulum	11/1081	184/7206	0.00021524011109
ko05110	Vibrio cholerae infection	21/1081	63/7206	0.000241273337357
ko04064	NF-kappa B signaling pathway	3/1081	96/7206	0.000253454232191
ko04260	Cardiac muscle contraction	29/1081	98/7206	0.000271393778421
ko04710	Circadian rhythm	16/1081	43/7206	0.000283666390113
ko05166	HTLV-I infection	24/1081	292/7206	0.0005624096588
ko04540	Gap junction	34/1081	128/7206	0.000629857841529
ko04610	Complement and coagulation cascades	2/1081	79/7206	0.000650903115569
ko03008	Ribosome biogenesis in eukaryotes	2/1081	79/7206	0.000650903115569
ko05140	Leishmaniasis	2/1081	75/7206	0.000909361415791
ko05162	Measles	6/1081	120/7206	0.00107799040928
ko05414	Dilated cardiomyopathy	30/1081	112/7206	0.00116287426104
ko04070	Phosphatidylinositol signaling system	30/1081	112/7206	0.00116287426104
ko04750	Inflammatory mediator regulation of TRP channels	32/1081	122/7206	0.00119622204484
ko04214	Apoptosis - fly	2/1081	72/7206	0.00132998061583
ko05161	Hepatitis B	12/1081	173/7206	0.00163834916719
ko04371	Apelin signaling pathway	42/1081	177/7206	0.00186161211949
ko04972	Pancreatic secretion	29/1081	111/7206	0.00190205611661
ko04014	Ras signaling pathway	61/1081	279/7206	0.00196914118643
ko00480	Glutathione metabolism	1/1081	55/7206	0.00210669353664
ko04146	Peroxisome	4/1081	89/7206	0.00258876513341
ko04626	Plant-pathogen interaction	8/1081	18/7206	0.00268474857685
ko04510	Focal adhesion	21/1081	240/7206	0.00428045050861
ko04922	Glucagon signaling pathway	31/1081	128/7206	0.00559119300734
ko04072	Phospholipase D signaling pathway	44/1081	197/7206	0.00598355333669
ko04330	Notch signaling pathway	2/1081	62/7206	0.00627956949558
ko05219	Bladder cancer	1/1081	48/7206	0.00713419775186
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1081	100/7206	0.00722790166792
ko04976	Bile secretion	21/1081	80/7206	0.00725910578532
ko04964	Proximal tubule bicarbonate reclamation	10/1081	29/7206	0.00730741802503
ko00240	Pyrimidine metabolism	7/1081	110/7206	0.00978723855125
ko04923	Regulation of lipolysis in adipocytes	20/1081	77/7206	0.0100236620537
ko03022	Basal transcription factors	1/1081	44/7206	0.0105152834872
ko00071	Fatty acid degradation	1/1081	45/7206	0.0105739044051
ko04210	Apoptosis	15/1081	180/7206	0.01071143368
ko03420	Nucleotide excision repair	1/1081	46/7206	0.0109402876168
ko05145	Toxoplasmosis	9/1081	126/7206	0.0112081422221
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1081	14/7206	0.0114545968206
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1081	92/7206	0.011566815368
ko04930	Type II diabetes mellitus	15/1081	54/7206	0.012634133442
ko05321	Inflammatory bowel disease (IBD)	2/1081	56/7206	0.0130197452391
ko04630	Jak-STAT signaling pathway	10/1081	132/7206	0.0134641781563
ko01524	Platinum drug resistance	4/1081	76/7206	0.0143253190462
ko04657	IL-17 signaling pathway	5/1081	87/7206	0.01445013589
ko04350	TGF-beta signaling pathway	7/1081	103/7206	0.01728423103
ko04915	Estrogen signaling pathway	30/1081	131/7206	0.0180879673058
ko05200	Pathways in cancer	56/1081	492/7206	0.0185241727916
ko05131	Shigellosis	5/1081	82/7206	0.0191754978387
ko04668	TNF signaling pathway	9/1081	120/7206	0.0195082085372
ko04622	RIG-I-like receptor signaling pathway	3/1081	62/7206	0.0195860268145
ko00310	Lysine degradation	4/1081	73/7206	0.0198630200166
ko04115	p53 signaling pathway	4/1081	74/7206	0.020328348989
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1081	40/7206	0.0236961121055
ko05206	MicroRNAs in cancer	16/1081	177/7206	0.0246412991275
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1081	182/7206	0.0273327789241
ko00330	Arginine and proline metabolism	3/1081	61/7206	0.028454433722
ko05016	Huntington's disease	21/1081	215/7206	0.0322652440801
ko05133	Pertussis	6/1081	87/7206	0.03331298524
ko04711	Circadian rhythm - fly	5/1081	13/7206	0.0340413195918
ko00982	Drug metabolism - cytochrome P450	1/1081	37/7206	0.0348832683656
ko00630	Glyoxylate and dicarboxylate metabolism	1/1081	38/7206	0.0362092949959
ko05217	Basal cell carcinoma	4/1081	68/7206	0.0384369734988
ko04961	Endocrine and other factor-regulated calcium reabsorption	15/1081	59/7206	0.0411018318003
ko04217	Necroptosis	17/1081	178/7206	0.0426976600959
ko05215	Prostate cancer	9/1081	111/7206	0.0434082359487
ko04960	Aldosterone-regulated sodium reabsorption	11/1081	41/7206	0.0454719765967