ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	192/1144	423/7206	4.07312503916e-50
ko04724	Glutamatergic synapse	89/1144	152/7206	6.67434315095e-34
ko05033	Nicotine addiction	49/1144	56/7206	2.11538287744e-32
ko05032	Morphine addiction	69/1144	110/7206	4.55549850504e-29
ko04727	GABAergic synapse	66/1144	110/7206	3.1934572182e-26
ko04713	Circadian entrainment	73/1144	136/7206	1.01719414013e-24
ko04721	Synaptic vesicle cycle	52/1144	80/7206	3.13392418205e-23
ko04728	Dopaminergic synapse	84/1144	185/7206	6.53745809557e-22
ko04725	Cholinergic synapse	75/1144	160/7206	1.08832551387e-20
ko04723	Retrograde endocannabinoid signaling	78/1144	175/7206	8.28127918255e-20
ko04024	cAMP signaling pathway	102/1144	279/7206	7.18833007689e-18
ko04742	Taste transduction	38/1144	61/7206	2.22489972854e-16
ko04020	Calcium signaling pathway	95/1144	265/7206	5.49123525328e-16
ko04921	Oxytocin signaling pathway	79/1144	209/7206	5.19972359161e-15
ko04911	Insulin secretion	54/1144	117/7206	7.36233752698e-15
ko04744	Phototransduction	26/1144	36/7206	6.52177821355e-14
ko04726	Serotonergic synapse	58/1144	137/7206	8.18799924486e-14
ko04261	Adrenergic signaling in cardiomyocytes	74/1144	205/7206	7.94252679427e-13
ko04720	Long-term potentiation	44/1144	99/7206	1.19247160498e-11
ko05031	Amphetamine addiction	41/1144	91/7206	3.54765556308e-11
ko03040	Spliceosome	1/1144	145/7206	5.14464601152e-10
ko04970	Salivary secretion	40/1144	95/7206	7.65187652877e-10
ko05203	Viral carcinogenesis	14/1144	277/7206	2.04927000292e-08
ko04740	Olfactory transduction	33/1144	80/7206	4.32097142267e-08
ko04925	Aldosterone synthesis and secretion	39/1144	105/7206	9.22555281723e-08
ko04060	Cytokine-cytokine receptor interaction	7/1144	191/7206	1.03686675461e-07
ko04971	Gastric acid secretion	37/1144	98/7206	1.45234936344e-07
ko05030	Cocaine addiction	30/1144	73/7206	1.96232285109e-07
ko04360	Axon guidance	68/1144	233/7206	2.11129541744e-07
ko05168	Herpes simplex infection	7/1144	182/7206	4.81489356833e-07
ko04022	cGMP-PKG signaling pathway	63/1144	216/7206	5.85587094151e-07
ko05322	Systemic lupus erythematosus	5/1144	151/7206	1.35029583029e-06
ko04070	Phosphatidylinositol signaling system	38/1144	112/7206	2.5113788303e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1144	74/7206	3.57729807002e-06
ko03013	RNA transport	7/1144	166/7206	4.25588145637e-06
ko04010	MAPK signaling pathway	82/1144	321/7206	4.94528682674e-06
ko04966	Collecting duct acid secretion	14/1144	26/7206	8.76765091817e-06
ko05164	Influenza A	8/1144	167/7206	1.33619033709e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1144	79/7206	1.63966399913e-05
ko04141	Protein processing in endoplasmic reticulum	10/1144	184/7206	2.13942356613e-05
ko04072	Phospholipase D signaling pathway	54/1144	197/7206	2.73576522186e-05
ko04610	Complement and coagulation cascades	1/1144	79/7206	3.27102670747e-05
ko05414	Dilated cardiomyopathy	35/1144	112/7206	3.88434803732e-05
ko04110	Cell cycle	7/1144	145/7206	4.83339922619e-05
ko04621	NOD-like receptor signaling pathway	8/1144	157/7206	5.41857182832e-05
ko05110	Vibrio cholerae infection	23/1144	63/7206	6.87764064963e-05
ko04540	Gap junction	38/1144	128/7206	7.15793774702e-05
ko05169	Epstein-Barr virus infection	14/1144	206/7206	9.81755056464e-05
ko04745	Phototransduction - fly	16/1144	38/7206	0.000100787740421
ko04972	Pancreatic secretion	34/1144	111/7206	0.000105642359787
ko04064	NF-kappa B signaling pathway	3/1144	96/7206	0.000110619410718
ko04260	Cardiac muscle contraction	31/1144	98/7206	0.000119238177056
ko04730	Long-term depression	26/1144	78/7206	0.000121568467736
ko04514	Cell adhesion molecules (CAMs)	38/1144	130/7206	0.000133761467722
ko04924	Renin secretion	28/1144	86/7206	0.00013659805724
ko04915	Estrogen signaling pathway	37/1144	131/7206	0.000259692653665
ko03008	Ribosome biogenesis in eukaryotes	2/1144	79/7206	0.000267248145249
ko05205	Proteoglycans in cancer	23/1144	271/7206	0.000352708310175
ko05140	Leishmaniasis	2/1144	75/7206	0.000390084520599
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1144	59/7206	0.000522850407076
ko04120	Ubiquitin mediated proteolysis	8/1144	138/7206	0.000548973611172
ko04014	Ras signaling pathway	66/1144	279/7206	0.000572250438851
ko04626	Plant-pathogen interaction	9/1144	18/7206	0.000772347494524
ko04371	Apelin signaling pathway	45/1144	177/7206	0.00112369887751
ko00480	Glutathione metabolism	1/1144	55/7206	0.00133078006395
ko00240	Pyrimidine metabolism	6/1144	110/7206	0.00139295321961
ko05162	Measles	7/1144	120/7206	0.00142729253992
ko05161	Hepatitis B	13/1144	173/7206	0.00145822118486
ko04612	Antigen processing and presentation	3/1144	77/7206	0.00154098272597
ko04750	Inflammatory mediator regulation of TRP channels	33/1144	122/7206	0.00156772788678
ko04976	Bile secretion	24/1144	80/7206	0.00169158509545
ko04146	Peroxisome	4/1144	89/7206	0.00182094437433
ko00590	Arachidonic acid metabolism	1/1144	52/7206	0.00200627398317
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1144	14/7206	0.00305861019726
ko00562	Inositol phosphate metabolism	25/1144	89/7206	0.00312185585477
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1144	100/7206	0.00367180882402
ko04923	Regulation of lipolysis in adipocytes	22/1144	77/7206	0.00427384087135
ko05144	Malaria	1/1144	45/7206	0.00679647724815
ko00071	Fatty acid degradation	1/1144	45/7206	0.00679647724815
ko03022	Basal transcription factors	1/1144	44/7206	0.00680154233647
ko01524	Platinum drug resistance	4/1144	76/7206	0.00697969549147
ko03420	Nucleotide excision repair	1/1144	46/7206	0.00702533821315
ko05321	Inflammatory bowel disease (IBD)	2/1144	56/7206	0.00879391414868
ko04350	TGF-beta signaling pathway	7/1144	103/7206	0.00923236487422
ko04640	Hematopoietic cell lineage	3/1144	64/7206	0.00941219053285
ko00310	Lysine degradation	4/1144	73/7206	0.00982058517535
ko04912	GnRH signaling pathway	30/1144	122/7206	0.0118755248593
ko05145	Toxoplasmosis	10/1144	126/7206	0.0132195506685
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1144	182/7206	0.0133148906156
ko00330	Arginine and proline metabolism	3/1144	61/7206	0.0134048478422
ko04622	RIG-I-like receptor signaling pathway	3/1144	62/7206	0.0134754116142
ko04214	Apoptosis - fly	4/1144	72/7206	0.0139076012923
ko04922	Glucagon signaling pathway	31/1144	128/7206	0.013971244966
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1144	40/7206	0.0152511490881
ko04630	Jak-STAT signaling pathway	11/1144	132/7206	0.0156045484328
ko00140	Steroid hormone biosynthesis	1/1144	41/7206	0.0158391354974
ko04658	Th1 and Th2 cell differentiation	7/1144	96/7206	0.0166374051253
ko04964	Proximal tubule bicarbonate reclamation	10/1144	29/7206	0.0174669138013
ko05166	HTLV-I infection	32/1144	292/7206	0.0176150613561
ko04657	IL-17 signaling pathway	6/1144	87/7206	0.0177224851117
ko05133	Pertussis	6/1144	87/7206	0.0177224851117
ko04510	Focal adhesion	25/1144	240/7206	0.0190982026446
ko00982	Drug metabolism - cytochrome P450	1/1144	37/7206	0.022592232702
ko00630	Glyoxylate and dicarboxylate metabolism	1/1144	38/7206	0.0231707790372
ko03410	Base excision repair	1/1144	38/7206	0.0231707790372
ko03018	RNA degradation	6/1144	84/7206	0.0239814714556
ko04114	Oocyte meiosis	32/1144	139/7206	0.0254023387925
ko05418	Fluid shear stress and atherosclerosis	17/1144	173/7206	0.0266492394027
ko00260	Glycine, serine and threonine metabolism	2/1144	48/7206	0.0266738349117
ko04722	Neurotrophin signaling pathway	36/1144	160/7206	0.0279022254859
ko04210	Apoptosis	18/1144	180/7206	0.0295509186854
ko04140	Autophagy - animal	16/1144	164/7206	0.0301376237668
ko05131	Shigellosis	6/1144	82/7206	0.0323996117845
ko04973	Carbohydrate digestion and absorption	12/1144	42/7206	0.0326215412896
ko04115	p53 signaling pathway	5/1144	74/7206	0.0357101728251
ko04217	Necroptosis	18/1144	178/7206	0.0370378231787
ko04062	Chemokine signaling pathway	43/1144	201/7206	0.0391072641498
ko05222	Small cell lung cancer	7/1144	89/7206	0.0397893278402
ko05231	Choline metabolism in cancer	30/1144	134/7206	0.0423315719758
ko04670	Leukocyte transendothelial migration	15/1144	151/7206	0.0426813761011
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1144	92/7206	0.0431666569357
ko04270	Vascular smooth muscle contraction	34/1144	154/7206	0.0438575345034
ko03320	PPAR signaling pathway	5/1144	69/7206	0.0470362035853
ko04136	Autophagy - other	1/1144	31/7206	0.0498603690927