ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	189/1147	423/7206	7.88281994821e-48
ko04724	Glutamatergic synapse	91/1147	152/7206	1.21359687467e-35
ko05033	Nicotine addiction	48/1147	56/7206	8.14233919765e-31
ko05032	Morphine addiction	65/1147	110/7206	3.06088719139e-25
ko04713	Circadian entrainment	73/1147	136/7206	1.20170834386e-24
ko04727	GABAergic synapse	64/1147	110/7206	2.41485245106e-24
ko04721	Synaptic vesicle cycle	53/1147	80/7206	3.38889510934e-24
ko04728	Dopaminergic synapse	84/1147	185/7206	7.81767569114e-22
ko04725	Cholinergic synapse	76/1147	160/7206	2.55042626897e-21
ko04723	Retrograde endocannabinoid signaling	77/1147	175/7206	4.35653123603e-19
ko04024	cAMP signaling pathway	100/1147	279/7206	9.25961411693e-17
ko04020	Calcium signaling pathway	94/1147	265/7206	1.69828891263e-15
ko04742	Taste transduction	37/1147	61/7206	2.11452534836e-15
ko04921	Oxytocin signaling pathway	79/1147	209/7206	1.02107242855e-14
ko04726	Serotonergic synapse	59/1147	137/7206	2.22395209505e-14
ko04911	Insulin secretion	53/1147	117/7206	3.85245345421e-14
ko04744	Phototransduction	26/1147	36/7206	6.9536660201e-14
ko04720	Long-term potentiation	47/1147	99/7206	1.26387170969e-13
ko05031	Amphetamine addiction	42/1147	91/7206	8.36459992728e-12
ko04261	Adrenergic signaling in cardiomyocytes	71/1147	205/7206	2.20463787317e-11
ko03040	Spliceosome	1/1147	145/7206	5.19498204806e-10
ko04970	Salivary secretion	40/1147	95/7206	8.29127862542e-10
ko04740	Olfactory transduction	34/1147	80/7206	1.16209672389e-08
ko05168	Herpes simplex infection	5/1147	182/7206	1.30359406715e-08
ko05203	Viral carcinogenesis	14/1147	277/7206	2.03536674288e-08
ko04360	Axon guidance	69/1147	233/7206	8.3209589338e-08
ko04925	Aldosterone synthesis and secretion	39/1147	105/7206	9.77510567074e-08
ko04971	Gastric acid secretion	37/1147	98/7206	1.5104397647e-07
ko04060	Cytokine-cytokine receptor interaction	8/1147	191/7206	5.5596583455e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1147	74/7206	1.08906936376e-06
ko04966	Collecting duct acid secretion	15/1147	26/7206	1.32443757848e-06
ko04120	Ubiquitin mediated proteolysis	4/1147	138/7206	1.4820191754e-06
ko04022	cGMP-PKG signaling pathway	62/1147	216/7206	1.62349106497e-06
ko04621	NOD-like receptor signaling pathway	6/1147	157/7206	2.38707989778e-06
ko05030	Cocaine addiction	28/1147	73/7206	2.75592267294e-06
ko03013	RNA transport	7/1147	166/7206	2.82199477134e-06
ko04540	Gap junction	41/1147	128/7206	4.30074030897e-06
ko04514	Cell adhesion molecules (CAMs)	41/1147	130/7206	8.28579936602e-06
ko04010	MAPK signaling pathway	81/1147	321/7206	1.06779852382e-05
ko05164	Influenza A	8/1147	167/7206	1.35042841868e-05
ko04924	Renin secretion	30/1147	86/7206	1.69522960061e-05
ko04260	Cardiac muscle contraction	33/1147	98/7206	1.74073404273e-05
ko05322	Systemic lupus erythematosus	7/1147	151/7206	2.40416931496e-05
ko04745	Phototransduction - fly	17/1147	38/7206	2.45052373917e-05
ko04972	Pancreatic secretion	35/1147	111/7206	3.48049023288e-05
ko04730	Long-term depression	27/1147	78/7206	5.66851481903e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1147	79/7206	6.45253949258e-05
ko05110	Vibrio cholerae infection	23/1147	63/7206	7.04370390837e-05
ko05169	Epstein-Barr virus infection	14/1147	206/7206	9.77268974874e-05
ko04064	NF-kappa B signaling pathway	3/1147	96/7206	0.000110509588847
ko05414	Dilated cardiomyopathy	34/1147	112/7206	0.000118203478754
ko04070	Phosphatidylinositol signaling system	34/1147	112/7206	0.000118203478754
ko04141	Protein processing in endoplasmic reticulum	12/1147	184/7206	0.000141982648568
ko04072	Phospholipase D signaling pathway	52/1147	197/7206	0.000149151562587
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1147	59/7206	0.000204142303729
ko04610	Complement and coagulation cascades	2/1147	79/7206	0.000268465725706
ko03008	Ribosome biogenesis in eukaryotes	2/1147	79/7206	0.000268465725706
ko04976	Bile secretion	26/1147	80/7206	0.000284634568534
ko04014	Ras signaling pathway	67/1147	279/7206	0.000315729456848
ko05205	Proteoglycans in cancer	23/1147	271/7206	0.000351918038325
ko05162	Measles	6/1147	120/7206	0.000356053929065
ko05140	Leishmaniasis	2/1147	75/7206	0.00038821844141
ko04915	Estrogen signaling pathway	37/1147	131/7206	0.000390066886388
ko04612	Antigen processing and presentation	2/1147	77/7206	0.000410145148588
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1147	14/7206	0.000490569035947
ko04110	Cell cycle	9/1147	145/7206	0.00052519077937
ko04750	Inflammatory mediator regulation of TRP channels	34/1147	122/7206	0.000665756796785
ko04626	Plant-pathogen interaction	9/1147	18/7206	0.000787778239256
ko04964	Proximal tubule bicarbonate reclamation	12/1147	29/7206	0.000921570342332
ko04146	Peroxisome	4/1147	89/7206	0.0012170144781
ko00480	Glutathione metabolism	1/1147	55/7206	0.00132850976343
ko05161	Hepatitis B	13/1147	173/7206	0.00146441254957
ko04371	Apelin signaling pathway	44/1147	177/7206	0.0017194704127
ko00590	Arachidonic acid metabolism	1/1147	52/7206	0.00199901720376
ko04214	Apoptosis - fly	3/1147	72/7206	0.00319686885195
ko00310	Lysine degradation	3/1147	73/7206	0.00325344330461
ko00240	Pyrimidine metabolism	7/1147	110/7206	0.00361196946843
ko04912	GnRH signaling pathway	32/1147	122/7206	0.00370291385022
ko04923	Regulation of lipolysis in adipocytes	22/1147	77/7206	0.00435660473716
ko03022	Basal transcription factors	1/1147	44/7206	0.0067766423875
ko05144	Malaria	1/1147	45/7206	0.00679794960414
ko00071	Fatty acid degradation	1/1147	45/7206	0.00679794960414
ko01524	Platinum drug resistance	4/1147	76/7206	0.00696422489601
ko03420	Nucleotide excision repair	1/1147	46/7206	0.00705517142502
ko04657	IL-17 signaling pathway	5/1147	87/7206	0.00721433966115
ko04668	TNF signaling pathway	9/1147	120/7206	0.00804565854999
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1147	100/7206	0.00849158041452
ko05321	Inflammatory bowel disease (IBD)	2/1147	56/7206	0.00883673295104
ko04350	TGF-beta signaling pathway	7/1147	103/7206	0.00926327825962
ko04916	Melanogenesis	34/1147	142/7206	0.0107482395505
ko05166	HTLV-I infection	31/1147	292/7206	0.0111085691486
ko05145	Toxoplasmosis	10/1147	126/7206	0.01328341435
ko00330	Arginine and proline metabolism	3/1147	61/7206	0.0133754833909
ko04622	RIG-I-like receptor signaling pathway	3/1147	62/7206	0.0134918114888
ko04114	Oocyte meiosis	33/1147	139/7206	0.0138459535658
ko04062	Chemokine signaling pathway	45/1147	201/7206	0.01422523973
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1147	40/7206	0.0152652075883
ko04630	Jak-STAT signaling pathway	11/1147	132/7206	0.0156497298018
ko00140	Steroid hormone biosynthesis	1/1147	41/7206	0.0159060199346
ko00562	Inositol phosphate metabolism	23/1147	89/7206	0.0183927958483
ko00982	Drug metabolism - cytochrome P450	1/1147	37/7206	0.0225857719287
ko00630	Glyoxylate and dicarboxylate metabolism	1/1147	38/7206	0.0232328730467
ko03410	Base excision repair	1/1147	38/7206	0.0232328730467
ko04930	Type II diabetes mellitus	15/1147	54/7206	0.023806718822
ko03018	RNA degradation	6/1147	84/7206	0.0239503708592
ko04015	Rap1 signaling pathway	58/1147	278/7206	0.0240097132597
ko05010	Alzheimer's disease	44/1147	202/7206	0.0246504375204
ko04115	p53 signaling pathway	5/1147	74/7206	0.0254764608151
ko00260	Glycine, serine and threonine metabolism	2/1147	48/7206	0.026769925998
ko04922	Glucagon signaling pathway	30/1147	128/7206	0.0272276294468
ko05214	Glioma	20/1147	79/7206	0.0292373941435
ko04217	Necroptosis	18/1147	178/7206	0.0294404171156
ko04210	Apoptosis	18/1147	180/7206	0.02962217261
ko05131	Shigellosis	6/1147	82/7206	0.0324287166221
ko04973	Carbohydrate digestion and absorption	12/1147	42/7206	0.0330095073274
ko00640	Propanoate metabolism	1/1147	34/7206	0.0335036899557
ko04330	Notch signaling pathway	4/1147	62/7206	0.0366491612812
ko00600	Sphingolipid metabolism	4/1147	63/7206	0.036720919831
ko04213	Longevity regulating pathway - multiple species	21/1147	86/7206	0.0371569646325
ko05034	Alcoholism	50/1147	238/7206	0.0376512020165
ko00280	Valine, leucine and isoleucine degradation	3/1147	54/7206	0.0380578195199
ko05222	Small cell lung cancer	7/1147	89/7206	0.0398683301228
ko05231	Choline metabolism in cancer	30/1147	134/7206	0.0428302140952
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1147	92/7206	0.043557801492
ko04270	Vascular smooth muscle contraction	34/1147	154/7206	0.0441507673004
ko05418	Fluid shear stress and atherosclerosis	18/1147	173/7206	0.0453799310591
ko03320	PPAR signaling pathway	5/1147	69/7206	0.0469780460998
ko04658	Th1 and Th2 cell differentiation	8/1147	96/7206	0.0477208133327
ko04722	Neurotrophin signaling pathway	35/1147	160/7206	0.0482258812863