ko pathway ratio_in_study ratio_in_pop p_value ko04713 Circadian entrainment 36/509 136/7206 1.5225031962e-12 ko04724 Glutamatergic synapse 38/509 152/7206 2.46625148802e-12 ko04911 Insulin secretion 31/509 117/7206 5.54867068767e-11 ko05033 Nicotine addiction 21/509 56/7206 5.90655688502e-11 ko04727 GABAergic synapse 29/509 110/7206 2.68269700098e-10 ko04721 Synaptic vesicle cycle 24/509 80/7206 5.41488290517e-10 ko04725 Cholinergic synapse 35/509 160/7206 9.86389367178e-10 ko04728 Dopaminergic synapse 38/509 185/7206 1.25708001343e-09 ko04261 Adrenergic signaling in cardiomyocytes 40/509 205/7206 2.23918256393e-09 ko04022 cGMP-PKG signaling pathway 41/509 216/7206 3.3003792937e-09 ko04360 Axon guidance 43/509 233/7206 3.30489068309e-09 ko04921 Oxytocin signaling pathway 40/509 209/7206 4.03555474462e-09 ko04080 Neuroactive ligand-receptor interaction 63/509 423/7206 6.88018629674e-09 ko04020 Calcium signaling pathway 45/509 265/7206 2.32883225364e-08 ko05032 Morphine addiction 24/509 110/7206 4.72372913723e-07 ko04970 Salivary secretion 22/509 95/7206 4.80464076604e-07 ko04371 Apelin signaling pathway 31/509 177/7206 1.80414421243e-06 ko04024 cAMP signaling pathway 42/509 279/7206 2.08412676517e-06 ko04726 Serotonergic synapse 26/509 137/7206 2.68359475485e-06 ko05031 Amphetamine addiction 20/509 91/7206 3.80795472763e-06 ko04723 Retrograde endocannabinoid signaling 30/509 175/7206 6.48049160975e-06 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 18/509 79/7206 6.79144194926e-06 ko04974 Protein digestion and absorption 20/509 96/7206 9.02789423989e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 17/509 74/7206 1.08744837739e-05 ko04260 Cardiac muscle contraction 20/509 98/7206 1.25063619464e-05 ko04720 Long-term potentiation 20/509 99/7206 1.4662603465e-05 ko05410 Hypertrophic cardiomyopathy (HCM) 19/509 100/7206 5.85724106338e-05 ko04922 Glucagon signaling pathway 22/509 128/7206 7.72144606732e-05 ko04730 Long-term depression 16/509 78/7206 8.6276125358e-05 ko04964 Proximal tubule bicarbonate reclamation 9/509 29/7206 0.000113655515282 ko04010 MAPK signaling pathway 41/509 321/7206 0.000193119733624 ko05322 Systemic lupus erythematosus 1/509 151/7206 0.000310250902608 ko05168 Herpes simplex infection 2/509 182/7206 0.000327550768668 ko04512 ECM-receptor interaction 15/509 79/7206 0.000350019745849 ko04971 Gastric acid secretion 17/509 98/7206 0.00044316836085 ko03040 Spliceosome 1/509 145/7206 0.000455848960255 ko04151 PI3K-Akt signaling pathway 46/509 390/7206 0.000490790463873 ko00010 Glycolysis / Gluconeogenesis 14/509 74/7206 0.000568387729289 ko04514 Cell adhesion molecules (CAMs) 20/509 130/7206 0.000796634140092 ko04060 Cytokine-cytokine receptor interaction 3/509 191/7206 0.000843081567367 ko04745 Phototransduction - fly 9/509 38/7206 0.00104419357097 ko04626 Plant-pathogen interaction 6/509 18/7206 0.00107490610049 ko05414 Dilated cardiomyopathy 17/509 112/7206 0.00232969137359 ko04924 Renin secretion 14/509 86/7206 0.00258862594301 ko04742 Taste transduction 11/509 61/7206 0.0032257689737 ko03013 RNA transport 3/509 166/7206 0.00336451643066 ko04740 Olfactory transduction 13/509 80/7206 0.00369461408978 ko04120 Ubiquitin mediated proteolysis 2/509 138/7206 0.0040790814991 ko05030 Cocaine addiction 12/509 73/7206 0.00471892335695 ko05010 Alzheimer's disease 25/509 202/7206 0.00506585780721 ko04960 Aldosterone-regulated sodium reabsorption 8/509 41/7206 0.00702954703759 ko04961 Endocrine and other factor-regulated calcium reabsorption 10/509 59/7206 0.00767599911333 ko00680 Methane metabolism 7/509 34/7206 0.00849241965418 ko04270 Vascular smooth muscle contraction 19/509 154/7206 0.015873644035 ko05162 Measles 2/509 120/7206 0.0173990279619 ko02024 Quorum sensing 4/509 15/7206 0.0179538121302 ko04141 Protein processing in endoplasmic reticulum 5/509 184/7206 0.0183695759382 ko04925 Aldosterone synthesis and secretion 14/509 105/7206 0.0192390412095 ko04978 Mineral absorption 7/509 40/7206 0.0204292794462 ko01200 Carbon metabolism 16/509 128/7206 0.022400185154 ko00030 Pentose phosphate pathway 6/509 32/7206 0.0226081236735 ko04630 Jak-STAT signaling pathway 3/509 132/7206 0.0248343586582 ko04973 Carbohydrate digestion and absorption 7/509 42/7206 0.0261933260726 ko04916 Melanogenesis 17/509 142/7206 0.0298109741259 ko04015 Rap1 signaling pathway 29/509 278/7206 0.0311121581998 ko04014 Ras signaling pathway 29/509 279/7206 0.0316705059081 ko05164 Influenza A 5/509 167/7206 0.0323197521752 ko04972 Pancreatic secretion 14/509 111/7206 0.03653943595 ko00710 Carbon fixation in photosynthetic organisms 5/509 27/7206 0.0381291847598 ko04150 mTOR signaling pathway 6/509 184/7206 0.0402817138541 ko05203 Viral carcinogenesis 11/509 277/7206 0.0412109458209 ko01524 Platinum drug resistance 1/509 76/7206 0.0423781444742 ko04550 Signaling pathways regulating pluripotency of stem cells 5/509 165/7206 0.0437413339581 ko04114 Oocyte meiosis 16/509 139/7206 0.0447198110081