ko pathway ratio_in_study ratio_in_pop p_value ko04713 Circadian entrainment 23/273 136/7206 1.08958926665e-09 ko04921 Oxytocin signaling pathway 28/273 209/7206 3.97705195518e-09 ko04724 Glutamatergic synapse 23/273 152/7206 1.01367161403e-08 ko04922 Glucagon signaling pathway 20/273 128/7206 5.56616460707e-08 ko04911 Insulin secretion 19/273 117/7206 6.39971189285e-08 ko04745 Phototransduction - fly 11/273 38/7206 9.13640194835e-08 ko04261 Adrenergic signaling in cardiomyocytes 24/273 205/7206 7.09984887209e-07 ko04626 Plant-pathogen interaction 7/273 18/7206 2.30649699869e-06 ko04970 Salivary secretion 15/273 95/7206 2.33604462381e-06 ko04720 Long-term potentiation 15/273 99/7206 3.97604194446e-06 ko05031 Amphetamine addiction 14/273 91/7206 6.98417021461e-06 ko04925 Aldosterone synthesis and secretion 15/273 105/7206 8.37515654701e-06 ko04971 Gastric acid secretion 14/273 98/7206 1.68102980813e-05 ko04022 cGMP-PKG signaling pathway 22/273 216/7206 2.04514286541e-05 ko04360 Axon guidance 23/273 233/7206 2.19812825821e-05 ko04725 Cholinergic synapse 18/273 160/7206 3.15273611796e-05 ko04114 Oocyte meiosis 16/273 139/7206 6.5984342382e-05 ko04024 cAMP signaling pathway 25/273 279/7206 6.66582825829e-05 ko04728 Dopaminergic synapse 19/273 185/7206 6.77941569492e-05 ko04020 Calcium signaling pathway 24/273 265/7206 8.92678657849e-05 ko00010 Glycolysis / Gluconeogenesis 11/273 74/7206 9.42404081475e-05 ko04371 Apelin signaling pathway 18/273 177/7206 0.000119802897459 ko04740 Olfactory transduction 11/273 80/7206 0.000193114524218 ko00680 Methane metabolism 7/273 34/7206 0.000231456250239 ko00051 Fructose and mannose metabolism 7/273 42/7206 0.000895730162145 ko04070 Phosphatidylinositol signaling system 12/273 112/7206 0.00103145890454 ko01200 Carbon metabolism 13/273 128/7206 0.00106608016605 ko04514 Cell adhesion molecules (CAMs) 13/273 130/7206 0.00123139780035 ko04924 Renin secretion 10/273 86/7206 0.00143674384708 ko05014 Amyotrophic lateral sclerosis (ALS) 9/273 74/7206 0.00179654858135 ko05010 Alzheimer's disease 17/273 202/7206 0.00200196052417 ko04912 GnRH signaling pathway 12/273 122/7206 0.00216721125479 ko04966 Collecting duct acid secretion 5/273 26/7206 0.00257129608123 ko04721 Synaptic vesicle cycle 9/273 80/7206 0.00309434569516 ko04964 Proximal tubule bicarbonate reclamation 5/273 29/7206 0.0042311285488 ko01230 Biosynthesis of amino acids 9/273 85/7206 0.00466242579615 ko04710 Circadian rhythm 6/273 43/7206 0.00524311646964 ko05152 Tuberculosis 15/273 187/7206 0.00543380567523 ko04066 HIF-1 signaling pathway 11/273 123/7206 0.00675900592621 ko04727 GABAergic synapse 10/273 110/7206 0.00860469936573 ko05032 Morphine addiction 10/273 110/7206 0.00860469936573 ko04972 Pancreatic secretion 10/273 111/7206 0.00915040288166 ko05110 Vibrio cholerae infection 7/273 63/7206 0.00935583099252 ko05214 Glioma 8/273 79/7206 0.00973286890134 ko04152 AMPK signaling pathway 13/273 161/7206 0.00977763844319 ko04060 Cytokine-cytokine receptor interaction 1/273 191/7206 0.0107361754341 ko04260 Cardiac muscle contraction 9/273 98/7206 0.0116499369805 ko04270 Vascular smooth muscle contraction 12/273 154/7206 0.0161792096834 ko04978 Mineral absorption 5/273 40/7206 0.0167292422276 ko00710 Carbon fixation in photosynthetic organisms 4/273 27/7206 0.01778606641 ko00562 Inositol phosphate metabolism 8/273 89/7206 0.0190889970991 ko04726 Serotonergic synapse 11/273 137/7206 0.0193893319976 ko04722 Neurotrophin signaling pathway 12/273 160/7206 0.0200348912994 ko04973 Carbohydrate digestion and absorption 5/273 42/7206 0.0203488751584 ko04550 Signaling pathways regulating pluripotency of stem cells 1/273 165/7206 0.0217793073305 ko04916 Melanogenesis 11/273 142/7206 0.0225743998869 ko04919 Thyroid hormone signaling pathway 11/273 143/7206 0.0233214988668 ko04723 Retrograde endocannabinoid signaling 13/273 175/7206 0.0238846537506 ko04014 Ras signaling pathway 18/273 279/7206 0.0241561509674 ko04750 Inflammatory mediator regulation of TRP channels 10/273 122/7206 0.0256785871075 ko04730 Long-term depression 7/273 78/7206 0.0277447675938 ko00620 Pyruvate metabolism 5/273 46/7206 0.0290392650366 ko00030 Pentose phosphate pathway 4/273 32/7206 0.0314695597161 ko04068 FoxO signaling pathway 12/273 167/7206 0.0357668548409 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/273 1/7206 0.0378850957536 ko04016 MAPK signaling pathway - plant 3/273 20/7206 0.038053003177 ko03018 RNA degradation 7/273 84/7206 0.0393707908633 ko04144 Endocytosis 6/273 342/7206 0.0414037541767 ko00020 Citrate cycle (TCA cycle) 4/273 35/7206 0.0419816321846 ko00627 Aminobenzoate degradation 2/273 9/7206 0.043174745972 ko04213 Longevity regulating pathway - multiple species 7/273 86/7206 0.0438609141612 ko04918 Thyroid hormone synthesis 7/273 86/7206 0.0438609141612 ko03040 Spliceosome 1/273 145/7206 0.0452763908152