ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	206/1270	423/7206	3.08923102977e-52
ko04724	Glutamatergic synapse	90/1270	152/7206	3.94191763253e-31
ko05033	Nicotine addiction	48/1270	56/7206	1.01682966321e-28
ko05032	Morphine addiction	70/1270	110/7206	3.87025311406e-27
ko04713	Circadian entrainment	77/1270	136/7206	5.29489631236e-25
ko04727	GABAergic synapse	65/1270	110/7206	1.11319084142e-22
ko04721	Synaptic vesicle cycle	51/1270	80/7206	3.97667634652e-20
ko04728	Dopaminergic synapse	86/1270	185/7206	4.00282759103e-20
ko04024	cAMP signaling pathway	110/1270	279/7206	2.07985523395e-18
ko04725	Cholinergic synapse	75/1270	160/7206	6.07711654991e-18
ko04020	Calcium signaling pathway	103/1270	265/7206	7.1195276665e-17
ko04723	Retrograde endocannabinoid signaling	77/1270	175/7206	1.97338757114e-16
ko04726	Serotonergic synapse	65/1270	137/7206	4.94609416018e-16
ko04911	Insulin secretion	57/1270	117/7206	7.54305111294e-15
ko04742	Taste transduction	38/1270	61/7206	7.86445765199e-15
ko04921	Oxytocin signaling pathway	82/1270	209/7206	8.12854888977e-14
ko04744	Phototransduction	25/1270	36/7206	9.46108573657e-12
ko05031	Amphetamine addiction	44/1270	91/7206	1.29258293459e-11
ko04740	Olfactory transduction	40/1270	80/7206	2.9491301608e-11
ko04261	Adrenergic signaling in cardiomyocytes	74/1270	205/7206	1.52828839005e-10
ko04970	Salivary secretion	43/1270	95/7206	3.25303845456e-10
ko04720	Long-term potentiation	43/1270	99/7206	1.60215410646e-09
ko03040	Spliceosome	3/1270	145/7206	3.86810513118e-09
ko04925	Aldosterone synthesis and secretion	43/1270	105/7206	1.51998159601e-08
ko04022	cGMP-PKG signaling pathway	72/1270	216/7206	1.68556719692e-08
ko05168	Herpes simplex infection	7/1270	182/7206	1.73440727663e-08
ko05203	Viral carcinogenesis	18/1270	277/7206	5.06802346745e-08
ko05322	Systemic lupus erythematosus	5/1270	151/7206	1.06757011581e-07
ko05030	Cocaine addiction	31/1270	73/7206	5.66337023186e-07
ko04971	Gastric acid secretion	38/1270	98/7206	6.28510795863e-07
ko04966	Collecting duct acid secretion	16/1270	26/7206	7.12148948236e-07
ko04621	NOD-like receptor signaling pathway	8/1270	157/7206	3.76234820746e-06
ko03013	RNA transport	9/1270	166/7206	4.15178491209e-06
ko04120	Ubiquitin mediated proteolysis	6/1270	138/7206	4.16200637757e-06
ko05164	Influenza A	9/1270	167/7206	4.26948317104e-06
ko04060	Cytokine-cytokine receptor interaction	12/1270	191/7206	4.83459832468e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1270	74/7206	9.54735747981e-06
ko04540	Gap junction	43/1270	128/7206	1.03608445856e-05
ko04924	Renin secretion	32/1270	86/7206	1.23015229927e-05
ko04730	Long-term depression	30/1270	78/7206	1.42835666484e-05
ko04110	Cell cycle	8/1270	145/7206	2.20697196377e-05
ko04360	Axon guidance	67/1270	233/7206	2.2554766134e-05
ko04964	Proximal tubule bicarbonate reclamation	15/1270	29/7206	2.95597448077e-05
ko04514	Cell adhesion molecules (CAMs)	42/1270	130/7206	3.78732253121e-05
ko05162	Measles	6/1270	120/7206	5.30016000075e-05
ko05169	Epstein-Barr virus infection	16/1270	206/7206	5.72577053045e-05
ko04972	Pancreatic secretion	37/1270	111/7206	7.17286136917e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1270	79/7206	7.18015501275e-05
ko04010	MAPK signaling pathway	84/1270	321/7206	8.96128849772e-05
ko04745	Phototransduction - fly	17/1270	38/7206	9.42378562898e-05
ko04141	Protein processing in endoplasmic reticulum	14/1270	184/7206	0.000115314249095
ko04260	Cardiac muscle contraction	33/1270	98/7206	0.000134312739973
ko04976	Bile secretion	28/1270	80/7206	0.000165666883999
ko05166	HTLV-I infection	29/1270	292/7206	0.000217458187382
ko05110	Vibrio cholerae infection	23/1270	63/7206	0.000331926253449
ko04750	Inflammatory mediator regulation of TRP channels	37/1270	122/7206	0.000466687690512
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1270	79/7206	0.000478620410908
ko05140	Leishmaniasis	3/1270	75/7206	0.000652163716741
ko00240	Pyrimidine metabolism	7/1270	110/7206	0.000906011966355
ko04214	Apoptosis - fly	3/1270	72/7206	0.000950037265727
ko04014	Ras signaling pathway	71/1270	279/7206	0.000957320782859
ko05414	Dilated cardiomyopathy	34/1270	112/7206	0.000986819758856
ko04070	Phosphatidylinositol signaling system	34/1270	112/7206	0.000986819758856
ko05161	Hepatitis B	15/1270	173/7206	0.00112938551244
ko04270	Vascular smooth muscle contraction	43/1270	154/7206	0.00126382257612
ko04371	Apelin signaling pathway	48/1270	177/7206	0.00133526763445
ko04072	Phospholipase D signaling pathway	52/1270	197/7206	0.00169139047555
ko04064	NF-kappa B signaling pathway	6/1270	96/7206	0.00172995241098
ko04612	Antigen processing and presentation	4/1270	77/7206	0.00226794842107
ko00071	Fatty acid degradation	1/1270	45/7206	0.00273615125494
ko03420	Nucleotide excision repair	1/1270	46/7206	0.00281062329514
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1270	59/7206	0.00284007471882
ko05205	Proteoglycans in cancer	30/1270	271/7206	0.00331405113751
ko05131	Shigellosis	5/1270	82/7206	0.00333187424997
ko00280	Valine, leucine and isoleucine degradation	2/1270	54/7206	0.00363165626715
ko04630	Jak-STAT signaling pathway	11/1270	132/7206	0.00365373820967
ko00520	Amino sugar and nucleotide sugar metabolism	2/1270	55/7206	0.00372345605449
ko04923	Regulation of lipolysis in adipocytes	24/1270	77/7206	0.00372401125048
ko03022	Basal transcription factors	1/1270	44/7206	0.00433083436707
ko04146	Peroxisome	6/1270	89/7206	0.00468605236773
ko00590	Arachidonic acid metabolism	2/1270	52/7206	0.00537307293746
ko05145	Toxoplasmosis	11/1270	126/7206	0.00637325623466
ko04658	Th1 and Th2 cell differentiation	7/1270	96/7206	0.00639600452551
ko04330	Notch signaling pathway	3/1270	62/7206	0.00639919564212
ko04622	RIG-I-like receptor signaling pathway	3/1270	62/7206	0.00639919564212
ko04657	IL-17 signaling pathway	6/1270	87/7206	0.00653960094399
ko05133	Pertussis	6/1270	87/7206	0.00653960094399
ko04610	Complement and coagulation cascades	5/1270	79/7206	0.00676017037072
ko04710	Circadian rhythm	15/1270	43/7206	0.00735399612585
ko04626	Plant-pathogen interaction	8/1270	18/7206	0.00749555737629
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1270	182/7206	0.00776774429035
ko04620	Toll-like receptor signaling pathway	8/1270	100/7206	0.00800485363717
ko05212	Pancreatic cancer	6/1270	83/7206	0.00887921976187
ko03410	Base excision repair	1/1270	38/7206	0.00940740821188
ko04922	Glucagon signaling pathway	34/1270	128/7206	0.00987362754178
ko04916	Melanogenesis	37/1270	142/7206	0.010311837598
ko04915	Estrogen signaling pathway	35/1270	131/7206	0.0103305245816
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1270	100/7206	0.0112352208025
ko04930	Type II diabetes mellitus	17/1270	54/7206	0.011397719375
ko05222	Small cell lung cancer	7/1270	89/7206	0.0115331003491
ko05219	Bladder cancer	2/1270	48/7206	0.0118434629932
ko04217	Necroptosis	19/1270	178/7206	0.0124756798934
ko05321	Inflammatory bowel disease (IBD)	3/1270	56/7206	0.0125955565282
ko00310	Lysine degradation	5/1270	73/7206	0.0126977753215
ko05215	Prostate cancer	10/1270	111/7206	0.0162931664039
ko04210	Apoptosis	20/1270	180/7206	0.0221263869229
ko01524	Platinum drug resistance	6/1270	76/7206	0.022628198834
ko05200	Pathways in cancer	68/1270	492/7206	0.0231487008421
ko05217	Basal cell carcinoma	5/1270	68/7206	0.0241347588873
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1270	14/7206	0.0246373308781
ko04912	GnRH signaling pathway	31/1270	122/7206	0.0301675668247
ko04115	p53 signaling pathway	6/1270	74/7206	0.0307530505378
ko04350	TGF-beta signaling pathway	10/1270	103/7206	0.0361675268629
ko04550	Signaling pathways regulating pluripotency of stem cells	19/1270	165/7206	0.0382892976315
ko04142	Lysosome	17/1270	151/7206	0.0397433129052
ko05220	Chronic myeloid leukemia	8/1270	85/7206	0.0448590561191
ko00480	Glutathione metabolism	4/1270	55/7206	0.0486815269336
ko00562	Inositol phosphate metabolism	23/1270	89/7206	0.0491129837843