ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 23/196 152/7206 1.31668394538e-11 ko04020 Calcium signaling pathway 26/196 265/7206 9.78664093945e-09 ko04727 GABAergic synapse 16/196 110/7206 3.5952590998e-08 ko04925 Aldosterone synthesis and secretion 15/196 105/7206 1.25073514054e-07 ko04713 Circadian entrainment 17/196 136/7206 1.31295052091e-07 ko05032 Morphine addiction 15/196 110/7206 2.34409175603e-07 ko04070 Phosphatidylinositol signaling system 15/196 112/7206 2.98324149502e-07 ko04720 Long-term potentiation 14/196 99/7206 3.80108302917e-07 ko04723 Retrograde endocannabinoid signaling 18/196 175/7206 1.07475177827e-06 ko04911 Insulin secretion 14/196 117/7206 2.99086409362e-06 ko00562 Inositol phosphate metabolism 12/196 89/7206 4.43473506231e-06 ko04915 Estrogen signaling pathway 14/196 131/7206 1.13922979297e-05 ko04022 cGMP-PKG signaling pathway 18/196 216/7206 2.12451537811e-05 ko04725 Cholinergic synapse 15/196 160/7206 2.69998523056e-05 ko04261 Adrenergic signaling in cardiomyocytes 17/196 205/7206 3.86700302972e-05 ko04728 Dopaminergic synapse 16/196 185/7206 3.94817233238e-05 ko04072 Phospholipase D signaling pathway 16/196 197/7206 8.44331176472e-05 ko05033 Nicotine addiction 8/196 56/7206 0.000120322651689 ko05031 Amphetamine addiction 10/196 91/7206 0.000166627126533 ko04921 Oxytocin signaling pathway 16/196 209/7206 0.000169308898552 ko04080 Neuroactive ligand-receptor interaction 25/196 423/7206 0.000265904047789 ko04912 GnRH signaling pathway 11/196 122/7206 0.000458096439175 ko04918 Thyroid hormone synthesis 9/196 86/7206 0.000510462599529 ko04024 cAMP signaling pathway 18/196 279/7206 0.000556504664634 ko05030 Cocaine addiction 8/196 73/7206 0.000767410522064 ko04972 Pancreatic secretion 10/196 111/7206 0.000834662822595 ko05231 Choline metabolism in cancer 11/196 134/7206 0.00101071512575 ko04371 Apelin signaling pathway 13/196 177/7206 0.00102520331275 ko04970 Salivary secretion 9/196 95/7206 0.00105708341974 ko04730 Long-term depression 8/196 78/7206 0.00119233160505 ko04010 MAPK signaling pathway 19/196 321/7206 0.00123273733537 ko04971 Gastric acid secretion 9/196 98/7206 0.00132009257578 ko04540 Gap junction 10/196 128/7206 0.00246560376385 ko05414 Dilated cardiomyopathy 9/196 112/7206 0.00332756416803 ko04745 Phototransduction - fly 5/196 38/7206 0.00342228926105 ko04726 Serotonergic synapse 10/196 137/7206 0.00403759375979 ko00564 Glycerophospholipid metabolism 8/196 99/7206 0.00536520648686 ko04750 Inflammatory mediator regulation of TRP channels 9/196 122/7206 0.00585685900125 ko04740 Olfactory transduction 7/196 80/7206 0.00587808225615 ko04742 Taste transduction 6/196 61/7206 0.00600857609338 ko04211 Longevity regulating pathway 9/196 123/7206 0.00617451637427 ko04914 Progesterone-mediated oocyte maturation 8/196 104/7206 0.00719673549527 ko04270 Vascular smooth muscle contraction 10/196 154/7206 0.00908552746214 ko04320 Dorso-ventral axis formation 4/196 31/7206 0.00939808777522 ko04062 Chemokine signaling pathway 12/196 201/7206 0.0121474612963 ko05034 Alcoholism 13/196 238/7206 0.0140383465351 ko04923 Regulation of lipolysis in adipocytes 6/196 77/7206 0.0179741916574 ko04015 Rap1 signaling pathway 14/196 278/7206 0.0227239531011 ko04922 Glucagon signaling pathway 8/196 128/7206 0.0230896411653 ko00561 Glycerolipid metabolism 5/196 63/7206 0.0278331483618 ko04012 ErbB signaling pathway 7/196 109/7206 0.0286668335569 ko04213 Longevity regulating pathway - multiple species 6/196 86/7206 0.0292180759121 ko04924 Renin secretion 6/196 86/7206 0.0292180759121 ko04360 Axon guidance 12/196 233/7206 0.0360946993553 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 3/196 28/7206 0.0394116200402 ko00512 Mucin type O-glycan biosynthesis 3/196 29/7206 0.0431053160599 ko04611 Platelet activation 9/196 163/7206 0.043988693854 ko00514 Other types of O-glycan biosynthesis 3/196 30/7206 0.0469659326231