ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 26/218 134/7206 1.53798092471e-14 ko04060 Cytokine-cytokine receptor interaction 27/218 191/7206 1.31637830232e-11 ko04621 NOD-like receptor signaling pathway 24/218 157/7206 3.64716927816e-11 ko05162 Measles 19/218 120/7206 2.43969113881e-09 ko04064 NF-kappa B signaling pathway 17/218 96/7206 3.00021253511e-09 ko05164 Influenza A 22/218 167/7206 4.5791475661e-09 ko05140 Leishmaniasis 15/218 75/7206 4.59681866685e-09 ko04620 Toll-like receptor signaling pathway 17/218 100/7206 5.75029600861e-09 ko05152 Tuberculosis 23/218 187/7206 7.71924852734e-09 ko04650 Natural killer cell mediated cytotoxicity 16/218 97/7206 2.57055193211e-08 ko05161 Hepatitis B 21/218 173/7206 4.54771903821e-08 ko05321 Inflammatory bowel disease (IBD) 12/218 56/7206 7.49513779581e-08 ko04630 Jak-STAT signaling pathway 17/218 132/7206 3.93576732626e-07 ko05168 Herpes simplex infection 20/218 182/7206 5.02133760004e-07 ko05150 Staphylococcus aureus infection 9/218 36/7206 8.32230814088e-07 ko04660 T cell receptor signaling pathway 16/218 124/7206 8.53099671488e-07 ko04658 Th1 and Th2 cell differentiation 14/218 96/7206 9.4316204224e-07 ko05145 Toxoplasmosis 16/218 126/7206 1.06203183045e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 20/218 191/7206 1.09175930787e-06 ko04622 RIG-I-like receptor signaling pathway 11/218 62/7206 1.97506122887e-06 ko04662 B cell receptor signaling pathway 13/218 88/7206 2.00786625911e-06 ko05340 Primary immunodeficiency 8/218 30/7206 2.03359917022e-06 ko04668 TNF signaling pathway 15/218 120/7206 2.85042211788e-06 ko04659 Th17 cell differentiation 14/218 106/7206 3.18686786114e-06 ko05144 Malaria 9/218 45/7206 6.18000894596e-06 ko05323 Rheumatoid arthritis 12/218 89/7206 1.32014557126e-05 ko04610 Complement and coagulation cascades 11/218 79/7206 2.23462413945e-05 ko04217 Necroptosis 17/218 178/7206 2.4579641212e-05 ko04623 Cytosolic DNA-sensing pathway 8/218 41/7206 2.49104950927e-05 ko04666 Fc gamma R-mediated phagocytosis 13/218 122/7206 7.40245038324e-05 ko04664 Fc epsilon RI signaling pathway 10/218 77/7206 9.72416068123e-05 ko04672 Intestinal immune network for IgA production 7/218 37/7206 0.0001000143572 ko04210 Apoptosis 16/218 180/7206 0.000101984872334 ko04062 Chemokine signaling pathway 17/218 201/7206 0.000114774900741 ko05131 Shigellosis 10/218 82/7206 0.000166202423117 ko05160 Hepatitis C 14/218 153/7206 0.000205069567242 ko04933 AGE-RAGE signaling pathway in diabetic complications 13/218 135/7206 0.000208456604882 ko05133 Pertussis 10/218 87/7206 0.000272449209055 ko04611 Platelet activation 14/218 163/7206 0.000395935204422 ko05142 Chagas disease (American trypanosomiasis) 12/218 130/7206 0.00053838808267 ko05166 HTLV-I infection 20/218 292/7206 0.000611792911682 ko05330 Allograft rejection 5/218 24/7206 0.000642709877994 ko05169 Epstein-Barr virus infection 15/218 206/7206 0.00139440892595 ko05332 Graft-versus-host disease 4/218 18/7206 0.00178535888872 ko04670 Leukocyte transendothelial migration 12/218 151/7206 0.0020055724122 ko04612 Antigen processing and presentation 8/218 77/7206 0.0021566243243 ko04145 Phagosome 12/218 162/7206 0.00359709275915 ko04657 IL-17 signaling pathway 8/218 87/7206 0.00462984738165 ko05134 Legionellosis 7/218 74/7206 0.00679607384115 ko04072 Phospholipase D signaling pathway 13/218 197/7206 0.00877815430205 ko05132 Salmonella infection 8/218 98/7206 0.00940459983355 ko05320 Autoimmune thyroid disease 4/218 29/7206 0.0106871895625 ko04640 Hematopoietic cell lineage 6/218 64/7206 0.0124515021289 ko05310 Asthma 3/218 17/7206 0.0135715674218 ko04940 Type I diabetes mellitus 4/218 32/7206 0.0150820294986 ko04917 Prolactin signaling pathway 7/218 87/7206 0.0158931191877 ko05016 Huntington's disease 1/218 215/7206 0.0229526855247 ko04020 Calcium signaling pathway 2/218 265/7206 0.0257795824712 ko05130 Pathogenic Escherichia coli infection 6/218 77/7206 0.0285610043487 ko05146 Amoebiasis 7/218 99/7206 0.0299664375661 ko05418 Fluid shear stress and atherosclerosis 10/218 173/7206 0.041335570874 ko05220 Chronic myeloid leukemia 6/218 85/7206 0.0432994311567 ko04144 Endocytosis 17/218 342/7206 0.0493732127354