ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	170/1036	423/7206	1.14740122713e-41
ko05033	Nicotine addiction	48/1036	56/7206	6.35926452243e-33
ko04724	Glutamatergic synapse	84/1036	152/7206	8.9938751734e-33
ko04721	Synaptic vesicle cycle	54/1036	80/7206	1.73303078412e-27
ko04727	GABAergic synapse	62/1036	110/7206	4.77762470725e-25
ko04713	Circadian entrainment	68/1036	136/7206	2.53929127893e-23
ko05032	Morphine addiction	60/1036	110/7206	2.93559090111e-23
ko04728	Dopaminergic synapse	79/1036	185/7206	2.14201798475e-21
ko04725	Cholinergic synapse	69/1036	160/7206	4.27082230377e-19
ko04723	Retrograde endocannabinoid signaling	72/1036	175/7206	1.74815232519e-18
ko04024	cAMP signaling pathway	94/1036	279/7206	8.27064169933e-17
ko04742	Taste transduction	34/1036	61/7206	4.41443594963e-14
ko04911	Insulin secretion	50/1036	117/7206	5.70503661967e-14
ko04726	Serotonergic synapse	54/1036	137/7206	3.11464991569e-13
ko04720	Long-term potentiation	44/1036	99/7206	3.57315247734e-13
ko05031	Amphetamine addiction	41/1036	91/7206	1.32653030623e-12
ko04921	Oxytocin signaling pathway	69/1036	209/7206	3.93374311093e-12
ko04744	Phototransduction	22/1036	36/7206	1.21249613535e-10
ko04020	Calcium signaling pathway	77/1036	265/7206	3.05862649427e-10
ko04261	Adrenergic signaling in cardiomyocytes	63/1036	205/7206	1.632114611e-09
ko03040	Spliceosome	1/1036	145/7206	5.64099423791e-09
ko04360	Axon guidance	67/1036	233/7206	1.0128569611e-08
ko05030	Cocaine addiction	30/1036	73/7206	1.98725223654e-08
ko04971	Gastric acid secretion	35/1036	98/7206	9.46070276094e-08
ko05168	Herpes simplex infection	5/1036	182/7206	1.63677130441e-07
ko04010	MAPK signaling pathway	80/1036	321/7206	3.2707915084e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1036	74/7206	4.65232463477e-07
ko04925	Aldosterone synthesis and secretion	35/1036	105/7206	7.22068837661e-07
ko04060	Cytokine-cytokine receptor interaction	7/1036	191/7206	1.6660701113e-06
ko04970	Salivary secretion	32/1036	95/7206	1.85910113161e-06
ko05203	Viral carcinogenesis	15/1036	277/7206	1.93877950071e-06
ko04966	Collecting duct acid secretion	14/1036	26/7206	2.63287623109e-06
ko04740	Olfactory transduction	28/1036	80/7206	2.87941413416e-06
ko04621	NOD-like receptor signaling pathway	5/1036	157/7206	4.85128200777e-06
ko03013	RNA transport	6/1036	166/7206	8.69003265996e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1036	79/7206	1.16201508718e-05
ko04120	Ubiquitin mediated proteolysis	4/1036	138/7206	1.18600749539e-05
ko04260	Cardiac muscle contraction	31/1036	98/7206	1.35157078671e-05
ko04072	Phospholipase D signaling pathway	50/1036	197/7206	3.22352090476e-05
ko04540	Gap junction	36/1036	128/7206	5.67764327377e-05
ko04022	cGMP-PKG signaling pathway	52/1036	216/7206	0.000109005806978
ko04014	Ras signaling pathway	64/1036	279/7206	0.000112614898935
ko05164	Influenza A	8/1036	167/7206	0.000118859957776
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1036	59/7206	0.00012472003163
ko03008	Ribosome biogenesis in eukaryotes	1/1036	79/7206	0.000131795284244
ko04141	Protein processing in endoplasmic reticulum	10/1036	184/7206	0.000165520123016
ko04514	Cell adhesion molecules (CAMs)	35/1036	130/7206	0.000195325659482
ko04070	Phosphatidylinositol signaling system	31/1036	112/7206	0.000199195835251
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1036	14/7206	0.000238066690876
ko04915	Estrogen signaling pathway	34/1036	131/7206	0.000384259011348
ko05110	Vibrio cholerae infection	20/1036	63/7206	0.000394598351792
ko04924	Renin secretion	25/1036	86/7206	0.000485561722134
ko04745	Phototransduction - fly	14/1036	38/7206	0.000488352589288
ko04730	Long-term depression	23/1036	78/7206	0.0004957426013
ko04972	Pancreatic secretion	30/1036	111/7206	0.000514435254987
ko04750	Inflammatory mediator regulation of TRP channels	32/1036	122/7206	0.000581904083848
ko04064	NF-kappa B signaling pathway	3/1036	96/7206	0.000585023193275
ko05322	Systemic lupus erythematosus	8/1036	151/7206	0.000587788901389
ko05169	Epstein-Barr virus infection	14/1036	206/7206	0.000837413409399
ko04612	Antigen processing and presentation	2/1036	77/7206	0.000937015897783
ko04350	TGF-beta signaling pathway	4/1036	103/7206	0.000949791490536
ko05140	Leishmaniasis	2/1036	75/7206	0.00137872224705
ko00240	Pyrimidine metabolism	5/1036	110/7206	0.00144345787084
ko05414	Dilated cardiomyopathy	29/1036	112/7206	0.00152082520362
ko04110	Cell cycle	9/1036	145/7206	0.00267270928836
ko04015	Rap1 signaling pathway	58/1036	278/7206	0.00289039910512
ko05145	Toxoplasmosis	7/1036	126/7206	0.0028962158493
ko04930	Type II diabetes mellitus	16/1036	54/7206	0.00312638320175
ko00480	Glutathione metabolism	1/1036	55/7206	0.00325648545127
ko05321	Inflammatory bowel disease (IBD)	1/1036	56/7206	0.00332341977941
ko05205	Proteoglycans in cancer	23/1036	271/7206	0.00350936487318
ko00590	Arachidonic acid metabolism	1/1036	52/7206	0.00485729510369
ko04916	Melanogenesis	33/1036	142/7206	0.00502173840149
ko04964	Proximal tubule bicarbonate reclamation	10/1036	29/7206	0.00537948448158
ko05162	Measles	7/1036	120/7206	0.00537977717268
ko04146	Peroxisome	4/1036	89/7206	0.0054857913062
ko05213	Endometrial cancer	17/1036	62/7206	0.00601511390402
ko04640	Hematopoietic cell lineage	2/1036	64/7206	0.0063193777962
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1036	92/7206	0.00644799277849
ko00310	Lysine degradation	3/1036	73/7206	0.00706029845415
ko03018	RNA degradation	4/1036	84/7206	0.00744930068585
ko05034	Alcoholism	49/1036	238/7206	0.00822471743798
ko05214	Glioma	20/1036	79/7206	0.00910522989326
ko00330	Arginine and proline metabolism	2/1036	61/7206	0.00914340492615
ko04626	Plant-pathogen interaction	7/1036	18/7206	0.00930017276748
ko04976	Bile secretion	20/1036	80/7206	0.00995751724846
ko04214	Apoptosis - fly	3/1036	72/7206	0.0102011578242
ko00620	Pyruvate metabolism	1/1036	46/7206	0.0107742798644
ko03420	Nucleotide excision repair	1/1036	46/7206	0.0107742798644
ko00260	Glycine, serine and threonine metabolism	1/1036	48/7206	0.0112305534788
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1036	15/7206	0.0136516785167
ko04973	Carbohydrate digestion and absorption	12/1036	42/7206	0.0141511529005
ko05161	Hepatitis B	14/1036	173/7206	0.0154125029002
ko03022	Basal transcription factors	1/1036	44/7206	0.0160868440348
ko04722	Neurotrophin signaling pathway	34/1036	160/7206	0.0162968623895
ko04371	Apelin signaling pathway	37/1036	177/7206	0.0165487894294
ko05144	Malaria	1/1036	45/7206	0.0165663270502
ko00071	Fatty acid degradation	1/1036	45/7206	0.0165663270502
ko04062	Chemokine signaling pathway	41/1036	201/7206	0.0185127420685
ko04912	GnRH signaling pathway	27/1036	122/7206	0.0186011389607
ko01524	Platinum drug resistance	4/1036	76/7206	0.0202429168848
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1036	100/7206	0.0204529995922
ko04962	Vasopressin-regulated water reabsorption	15/1036	58/7206	0.0217476163177
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1036	40/7206	0.0237599205004
ko00140	Steroid hormone biosynthesis	1/1036	41/7206	0.0237999900886
ko05231	Choline metabolism in cancer	29/1036	134/7206	0.0242392565934
ko00983	Drug metabolism - other enzymes	1/1036	42/7206	0.0244144772274
ko04622	RIG-I-like receptor signaling pathway	3/1036	62/7206	0.0281565486077
ko00600	Sphingolipid metabolism	3/1036	63/7206	0.0285363610786
ko01200	Carbon metabolism	10/1036	128/7206	0.0304142152515
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1036	182/7206	0.031608828151
ko04144	Endocytosis	63/1036	342/7206	0.0328331544459
ko04668	TNF signaling pathway	9/1036	120/7206	0.034491032521
ko00630	Glyoxylate and dicarboxylate metabolism	1/1036	38/7206	0.0351543799473
ko00982	Drug metabolism - cytochrome P450	1/1036	37/7206	0.0351776634739
ko03320	PPAR signaling pathway	4/1036	69/7206	0.0382377655353
ko05204	Chemical carcinogenesis	2/1036	48/7206	0.0388033046932
ko04960	Aldosterone-regulated sodium reabsorption	11/1036	41/7206	0.0399202328379
ko05166	HTLV-I infection	30/1036	292/7206	0.0409063744131
ko04630	Jak-STAT signaling pathway	11/1036	132/7206	0.0449573485407